Campylobacter Reactive Arthritis: A Systematic Review

Pope, Janet; Krizova, Adriana; Garg, Amit X.; Thiessen-Philbrook, Heather; Ouimet, Janine

doi:10.1016/j.semarthrit.2006.12.006

Cited by 169 publications

(94 citation statements)

References 66 publications

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“…It is likely that C. jejuni's invasive nature and disruption of epithelial barrier integrity combined with the stimulation of host proinflammatory cytokines and defensins play a composite role in gastroenteritis (11,15,37,64). However, our understanding of the sequence of events leading to postinfectious sequelae (for example, reactive arthritis and irritable bowel syndrome), now more frequently being associated with the bacterium (38,51), is minimal. This study identifies and characterizes an IL-6-mediated proinflammatory pathway induced by C. jejuni infections, which has shown significant links to the development of autoimmune and inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2

Friis¹,

Keelan

Taylor³

2009

Infect Immun

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Gastrointestinal disease caused by Campylobacter jejuni is characterized by localized inflammation and the destruction of the epithelial cell barrier that forms host innate protection against pathogens. This can lead to an imbalance in fluid transport across the gastrointestinal tract, resulting in severe diarrhea. The mechanisms of host cell receptor recognition of C. jejuni and downstream immune signaling pathways leading to this inflammatory disease, however, remain unclear. The aim of this study was to analyze the mechanisms involved in C. jejuni induction of the acute-phase inflammatory response regulator interleukin-6 (IL-6). Polarized intestinal epithelial Caco-2 monolayers responded to infections with Salmonella enterica serovar Typhimurium and eight isolates of C. jejuni by an increase in levels of expression and secretion of IL-6. No such IL-6 response, however, was produced upon infection with the human commensal organism Lactobacillus rhamnosus GG. The IL-6 signaling pathway was further characterized using short interfering RNA complexes to block gene expression. The inhibition of myeloid differentiation primary response protein 88 (MyD88) expression in this manner did not affect C. jejuni-induced IL-6 secretion, suggesting a MyD88-independent route to IL-6 signal transduction in C. jejuni-infected human epithelial cells. However, a significant reduction in levels of IL-6 was evident in the absence of Toll-like receptor 2 (TLR-2) expression, implying a requirement for TLR-2 in C. jejuni recognition. Caco-2 cells were also treated with heat-inactivated and purified membrane components of C. jejuni to isolate the factor responsible for triggering IL-6 signaling. The results demonstrate that C. jejuni surface polysaccharides induce IL-6 secretion from intestinal epithelial cells via TLR-2 in a MyD88-independent manner.

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Section: Discussionmentioning

confidence: 99%

Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2

Friis¹,

Keelan

Taylor³

2009

Infect Immun

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“…Symptoms can begin approximately 1 month following infection and resolve within a year, although in some patients this condition may persist for up to 5 years (256). In 2007, a systematic review by Pope and colleagues reported the incidence of reactive arthritis associated with Campylobacter infection to be 1 to 5% (257). Other studies have estimated the risk of reactive arthritis associated with Campylobacter infection to be 3 to 13%, compared with 0 to 9% for E. coli O157:H7, 2 to 15% for Salmonella, 1 to 10% for Shigella, and 0 to 14% for Yersinia (256).…”

Section: Reactive Arthritismentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

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SUMMARY Campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. The incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. The dramatic increase in North America, Europe, and Australia is alarming, and data from parts of Africa, Asia, and the Middle East indicate that campylobacteriosis is endemic in these areas, especially in children. In addition to C. jejuni , there is increasing recognition of the clinical importance of emerging Campylobacter species, including Campylobacter concisus and Campylobacter ureolyticus . Poultry is a major reservoir and source of transmission of campylobacteriosis to humans. Other risk factors include consumption of animal products and water, contact with animals, and international travel. Strategic implementation of multifaceted biocontrol measures to reduce the transmission of this group of pathogens is paramount for public health. Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come. This review provides a comprehensive overview of the global epidemiology, transmission, and clinical relevance of Campylobacter infection.

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“…The symptoms of campylobacteriosis can range from a mild, watery diarrhea to dysentery, often with abdominal pain and fever (1). Moreover, there are several serious postinfectious complications associated with C. jejuni, including reactive arthritis (38), Guillain-Barré syndrome (2), and irritable bowel syndrome (35,44).…”

mentioning

confidence: 99%

Discrimination of Major Capsular Types of Campylobacter jejuni by Multiplex PCR

et al. 2011

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The polysaccharide capsule (CPS) of Campylobacter jejuni is the major serodeterminant of the Penner serotyping scheme. There are 47 Penner serotypes of C. jejuni, 22 of which fall into complexes of related serotypes. A multiplex PCR method for determination of capsule types of Campylobacter jejuni which is simpler and more affordable than classical Penner typing was developed. Primers specific for each capsule type were designed on the basis of a database of gene sequences from the variable capsule loci of 8 strains of major serotypes sequenced in this study and 10 published sequences of other serotypes. DNA sequence analysis revealed a mosaic nature of the capsule loci, suggesting reassortment of genes by horizontal transfer, and demonstrated a high degree of conservation of genes within Penner complexes. The multiplex PCR can distinguish 17 individual serotypes in two PCRs with sensitivities and specificities ranging from 90 to 100% using 244 strains of known Penner type.

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Campylobacter Reactive Arthritis: A Systematic Review

Abstract: Objective-To review the literature on the epidemiology of Campylobacter associated ReA.

Cited by 169 publications

References 66 publications

Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2

Campylobacter jejuni Drives MyD88-Independent Interleukin-6 Secretion via Toll-Like Receptor 2

Global Epidemiology of Campylobacter Infection

Discrimination of Major Capsular Types of Campylobacter jejuni by Multiplex PCR

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