Can a mother’s polycystic ovary syndrome (PCOS)-related symptoms be used to predict the future clinical profile of PCOS in her adolescent daughter? A pilot study

Lidaka, Lasma; Grasmane, Adele; Lazdāne, Gunta; Dzīvīte-Krišāne, Iveta; Gailīte, Linda; Viberga, Ilze

doi:10.1080/13625187.2020.1795118

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Precocious puberty is usually characterized by early puberty and developmental abnormalities. According to the pathogenesis, it can be divided into central precocious puberty, peripheral precocious puberty, and incomplete or partial precocious puberty [1][2][3]. Idiopathic central precocious puberty (ICPP) is caused by declined sensitivity of hypothalamus to negative feedback of sex hormones and premature increase in the secretion and release of gonadotropin-releasing hormone, which a ict more girls than boys in clinical practice [4,5].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

Yuan

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To study the diagnostic value of combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels in children with idiopathic central precocious puberty (ICPP). Methods. 30 cases of children with ICPP admitted to our hospital from January 2019 to January 2021 were selected as the experimental group, and 30 healthy people during the same period were selected as the control group. Both groups received pelvic ultrasound and serum LH, FSH, and E2 detection; the two groups were compared in terms of serum indicators, combined diagnosis, specificity, and sensitivity. Results. There were statistical differences in height, leptin, bone age, and areola diameter between the two groups ( p < 0.05 ). The length of the uterus, the volume of the uterus, the area of the ovary, the volume of the ovary, and the maximum diameter of the follicle in the experimental group were larger than those in the control group ( p < 0.05 ). The endometrial thickness of the experimental group was significantly greater than that of the control group ( p < 0.05 ). The levels of serum LH, FSH, and E2 in the experimental group were significantly higher than those in the control group ( p < 0.05 ). The area of the combined detection was significantly larger than that of the single detection. The combined detection was superior to the single detection with respect to the area, standard error a, asymptotic Sig. B, and asymptotic 95% confidence interval ( p < 0.05 ). The sensitivity of the combined detection was significantly higher than that of the single detection. Conclusion. The combined detection of pelvic ultrasound and serum LH, FSH, and E2 levels may be a preferred technique for the diagnosis of children with ICPP due to its benefits of high sensitivity and accuracy. It is worthy of clinical promotion and application.

show abstract

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

Yuan

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…A growing percentage of girls are going through precocious puberty [ 2 , 3 ]. According to whether the hypothalamic-pituitary-gonadal axis (HPGA) occurs or not, precocious puberty is classified as central precocious puberty (CPP) with the HPGA occurring driven by early increased gonadotropin-releasing hormone (GnRH) secretion, which accounts for roughly 80% [ 4 , 5 ], and as peripheral precocious puberty (PPP) which is independent of GnRH secretion, as well as incomplete precocity, which is the variation of CPP, including premature pubarche (PP), premature adrenarche (PA), premature thelarche (PT) and premature menarche [ 6 – 9 ]. PT is caused by transient partial activation of HPGA and overproduction of follicle stimulating hormone (FSH) and is characterized by isolated breast development without any other signs of sexual maturation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid profile in girls with precocious puberty: a systematic review and meta-analysis

Jiang,

Gao,

Wang

et al. 2023

BMC Endocr Disord

View full text Add to dashboard Cite

Objective Many studies have investigated the impact of precocious puberty on cardiovascular disease (CVD) outcomes and the association between lipid profile levels and precocious puberty. However, the results have been inconsistent. The aim of this meta-analysis was to evaluate whether triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL)and low density lipoprotein (LDL) levels were altered in girls with precocious puberty compared with healthy controls. Methods References published before June 2022 in the EMBASE, Cochrane Library, PubMed and Web of Science databases were searched to identify eligible studies. A DerSimonian-Laird random-effects model was used to evaluate the overall standard mean difference (SMD) between precocious puberty and healthy controls. Subgroup analyses and sensitivity analyses were preformed, and publication bias was assessed. Results A total of 14 studies featuring 1023 girls with precocious puberty and 806 healthy girls were selected for analysis. The meta-analysis showed that TG (SMD: 0.28; 95% CI: 0.01 to 0.55; P = 0.04), TC (SMD: 0.30; 95% CI: 0.01 to 0.59; P = 0.04), LDL (SMD: 0.45; 95% CI: 0.07 to 0.84; P = 0.02)levels were significantly elevated in girls with precocious puberty. HDL levels did not change significantly (SMD: -0.06; 95% CI: -0.12 to 0.61; P = 0.62). Subgroup analyses revealed that the heterogeneity in the association between lipid profile and precocious puberty in this meta-analysis may arise from disease type, region, sample size, chronological age, body mass index difference and drug usage. Conclusion Lipid profile levels altered in girls with precocious puberty compared with healthy controls. In order to minimize the risk of CVD morbidity and mortality, early interventions were needed to prevent obesity in children and adolescents, especially those with precocious puberty.

show abstract

“…The prevalence of PCOS among Pakistani women is increasing and manifests itself in many different ways 4 . The symptom complex associated with anovulation was first documented in 1935 by Michael L. Leventhal and Irving F. Stein [5][6] . Diagnostic criteria for PCOS included obesity, hirsutism, and enlarged polycystic ovary.…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of Patients with Polycystic Ovary Syndrome at Tertiary Care Hospital

Rafiq¹,

Shah²,

Asghar³

2023

PJMHS

View full text Add to dashboard Cite

Polycystic ovary syndrome, with an incidence of up to 10%, is one of the communal causes of anovulation in females of reproductive age. Diagnostic criteria for PCOS include enlarged polycystic ovaries, obesity, hirsutism, and oligomenorrhea. These women are more susceptible to endometrial cancer, type II diabetes, dyslipidemia and premature atherosclerosis. Objective: The aim of this study was to determine the different clinical profiles of PCOS patients and to educate patients about the long-term outcomes related with this condition. Methods: This cross-sectional study was conducted at the obstetrics and gynaecology department of Ayub Teaching Hospital, Abbottabad for the duration from 1st January 2019 to 31st December 2019. The study included 110 people with oligomenorrhea, obesity, acne, infertility and hirsutism. Young women who had their menarche less than two years ago, women over 45 years of age, and patients receiving exogenous estrogen or progesterone therapy were excluded from the study. For the social sciences, data was entered and analyzed with SPSS 25.0. The percentages and mean values were determined for several parameters. Results: Of the 110 patients selected for this study, 46 (41.8%) were married and 64 (58.2%) were unmarried. In contrast to rural areas, there were more patients from urban areas (63.6% vs 36.4%). 6.4% of patients were underweight, 20% and 59.1% were overweight and obese. Most patients (71.8%) had oligomenorrhea or amenorrhea. 70% of patients gained weight, many of whom attributed this to menstrual problems. Infertility affected 30% of married patients. Hirsutism and acne were found in 21.8% and 25.5%, respectively. Acanthosis Nigricans, a manifestation of insulin resistance, was found in 31.8% of patients. Eight patients were taking medication for hyperprolactinemia, ten women (10%) had type 2 diabetes taking oral hypoglycemics for glycemic control, and six had hypertension. All patients underwent USG and 85 (77.3%) of them showed a characteristic necklace pattern of follicular arrangement. Conclusion: Using clinical features and ultrasonography in women, PCOS can be accurately diagnosed using the Rotterdam criteria. The two main findings we observed in our patients were weight gain and amenorrhea or oligomenorrhea. It is very important to inform and educate unmarried patients with PCOS about the relationship of this condition with infertility and chronic health problems. Keywords: Oligomenorrhea, PCOS, Anovulation and obesity

show abstract

Can a mother’s polycystic ovary syndrome (PCOS)-related symptoms be used to predict the future clinical profile of PCOS in her adolescent daughter? A pilot study

Cited by 4 publications

References 19 publications

Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

Diagnostic Value of Combined Detection of Pelvic Ultrasound and Serum LH, FSH, and E2 Levels in Children with Idiopathic Central Precocious Puberty

Lipid profile in girls with precocious puberty: a systematic review and meta-analysis

Clinical Profile of Patients with Polycystic Ovary Syndrome at Tertiary Care Hospital

Contact Info

Product

Resources

About