Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic?

Petrić, Domina

doi:10.20935/al4010

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the introduction of SARS-CoV-2 vaccines has brought about several new or exacerbated cases of SCLS [29,30]. Most cases of SARS-CoV-2 vaccination-induced SCLS have been reported with adenoviral vector and mRNA vaccines [31].…”

Section: Definition and Etiologymentioning

confidence: 99%

Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review

Afshar¹,

Rostami²,

Pirzaman³

et al. 2023

Preprint

View full text Add to dashboard Cite

Systemic capillary leak syndrome (SCLS) is an uncommon, potentially life-threatening disorder defined as recurrent attacks of pseudo-shock. This syndrome occurs due to the disruption of endothelial cells, which leads to increased vascular permeability, causing intravascular fluid to leak into the extravascular space and albumin to be retained in the interstitial space. SCLS can lead to hypovolemia, peripheral hypoperfusion, and acute renal insufficiency. The syndrome is presented with fever, generalized edema, pleural effusions, dyspnea, hypovolemia, hemoconcentration, prerenal azotemia, shock, and syncope. After ruling out other causes of hypovolemic shock, the diagnosis of SCLS can be considered on the presence of the classical triad of hypotension, hemoconcentration, and hypoalbuminemia. Eliminating the precipitating factors is the cornerstone of SCLS management. It is advisable to be very cautious and weigh the risks and benefits of vaccination of people with a history of this condition. This review will discuss and compare different aspects of SLCS after SARS-CoV-2 infection and COVID-19 vaccination.

show abstract

Section: Definition and Etiologymentioning

confidence: 99%