Can Algal Derived Bioactive Metabolites Serve as Potential Therapeutics for the Treatment of SARS-CoV-2 Like Viral Infection?

Bhatt, Ankita; Arora, Pratham; Prajapati, Sanjeev Kumar

doi:10.3389/fmicb.2020.596374

Cited by 27 publications

(25 citation statements)

References 44 publications

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“…The S protein removal by the bare algae is likely attributed to nonspecific binding associated with the presence of diverse functional groups (e.g., carboxyl or amino groups) on the algae surface. 30 The images shown in Figure S5 represent a homogeneous mixture of the ACE2-algae-robot and S protein after 6 h incubation compared to clear sediment of static ACE2-algae after 6 h incubation. These results explain further the fast and efficient removal using the ACE2-algae-robot in Figure 3 e. The ACE2-algae-robot also exhibits effective S protein removal in various media, including DI water, drinking water, and river water, as indicated by the similar kinetic profiles in Figure 3 f. These results reveal that the ACE2-algae-robot, with long-lasting motion and ACE2 receptor for S protein recognition, represents an attractive system to enhance environmental remediation in complex aqueous surroundings.…”

Section: Resultsmentioning

confidence: 99%

“…The ACE2-algae-robot also offers significant improvement (89%) in the removal of SARS-CoV-2 pseudovirus compared with control groups, including static ACE2-algae (31%), bare algae (63%), and cell-wall deficient algae (21%) ( Figure 4 e). These experiments were performed by immersing 2.5 × 10 5 of algae in a 50 μL drinking water sample containing 2 × 10 9 VG ml –1 (VG: viral genomes) pseudovirus for 16 h. In the control experiments, the viral binding capability of the bare algae is possibly attributed to both biosorption 30 and physical entrapment of the virus into the porous structure of the algae cell wall. 31 The fluorescence images in Figure 4 f and Figure S8 illustrate the minimal fluorescent virus signal with the ACE2-algae-robot treatment, corresponding to the virus removal efficiency data of Figure 4 e. Furthermore, we evaluated and compared the virus removal kinetic profiles in drinking water treated with the ACE2-algae-robot, bare algae, or static ACE2-algae ( Figure 4 g).…”

Section: Resultsmentioning

confidence: 99%

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ACE2 Receptor-Modified Algae-Based Microrobot for Removal of SARS-CoV-2 in Wastewater

Zhang

Yin

et al. 2021

J. Am. Chem. Soc.

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The coronavirus SARS-CoV-2 can survive in wastewater for several days with a potential risk of waterborne human transmission, hence posing challenges in containing the virus and reducing its spread. Herein, we report on an active biohybrid microrobot system that offers highly efficient capture and removal of target virus from various aquatic media. The algae-based microrobot is fabricated by using click chemistry to functionalize microalgae with angiotensin-converting enzyme 2 (ACE2) receptor against the SARS-CoV-2 spike protein. The resulting ACE2-algae-robot displays fast (>100 μm/s) and long-lasting (>24 h) self-propulsion in diverse aquatic media including drinking water and river water, obviating the need for external fuels. Such movement of the ACE2-algae-robot offers effective “on-the-fly” removal of SARS-CoV-2 spike proteins and SARS-CoV-2 pseudovirus. Specifically, the active biohybrid microrobot results in 95% removal of viral spike protein and 89% removal of pseudovirus, significantly exceeding the control groups such as static ACE2-algae and bare algae. These results suggest considerable promise of biologically functionalized algae toward the removal of viruses and other environmental threats from wastewater.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

ACE2 Receptor-Modified Algae-Based Microrobot for Removal of SARS-CoV-2 in Wastewater

Zhang

Yin

et al. 2021

J. Am. Chem. Soc.

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“…Additionally, phycocyanobilins (PCBs) are pigment compounds present in some types of cyanobacteria as well as the algae rhodophytes [ 32 , 33 , 44 ]. They have been shown to have antioxidant as well as anti-viral properties making them promising leads for COVID-19 therapy.…”

Section: Promising Compounds From Marine Algae Bacteria Sponges and Fish For Covid-19 Treatmentmentioning

confidence: 99%

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

2021

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The ongoing pandemic has led to an urgent need for novel drug discovery and potential therapeutics for Sars-CoV-2 infected patients. Although Remdesivir and the anti-inflammatory agent dexamethasone are currently on the market for treatment, Remdesivir lacks full efficacy and thus, more drugs are needed. This review was conducted through literature search of PubMed, MDPI, Google Scholar and Scopus. Upon review of existing literature, it is evident that marine organisms harbor numerous active metabolites with anti-viral properties that serve as potential leads for COVID-19 therapy. Inorganic polyphosphates (polyP) naturally found in marine bacteria and sponges have been shown to prevent viral entry, induce the innate immune response, and downregulate human ACE-2. Furthermore, several marine metabolites isolated from diverse sponges and algae have been shown to inhibit main protease (Mpro), a crucial protein required for the viral life cycle. Sulfated polysaccharides have also been shown to have potent anti-viral effects due to their anionic properties and high molecular weight. Likewise, select marine sponges produce bromotyrosines which have been shown to prevent viral entry, replication and protein synthesis. The numerous compounds isolated from marine resources demonstrate significant potential against COVID-19. The present review for the first time highlights marine bioactive compounds, their sources, and their anti-viral mechanisms of action, with a focus on potential COVID-19 treatment.

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“…The utilization of marine organisms to prevent or treat various infections has been done for a long time and is still being done in treating various complex diseases such as cancer, various viral diseases, and malaria. These compounds have the potential of having pharmacological activities such as anti-tumor, antiviral, antioxidant, anti-microbial, and anti-coagulant (Bhatt et al 2020) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Exploring the therapeutic potential of marine-derived bioactive compounds against COVID-19

Singh

Chauhan

Kuddus

2021

Environ Sci Pollut Res

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The ocean is the most biodiverse habitat of various organisms. The organisms surviving in the harsh conditions of the ocean consist of several spectacular properties and produce bioactive compounds of pharmacological importance. These compounds are effective even in small quantities with various immunomodulatory qualities such as antioxidant and anti-inflammatory properties. Though the vaccines for COVID-19 are developed, and drug development is also in progress, but till now no effective drug is available for this deadly virus. Researchers are mining the huge data of bioactive compounds to develop the specific drug for COVID-19. The use of the repurposed drugs is challenging against the rapidly mutating virus with variable symptoms and mode of transmission. This review is an attempt to compile all the spattered data of marine-derived bioactive compounds with antiviral properties and to explore their therapeutic potential against COVID-19.

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Can Algal Derived Bioactive Metabolites Serve as Potential Therapeutics for the Treatment of SARS-CoV-2 Like Viral Infection?

Cited by 27 publications

References 44 publications

ACE2 Receptor-Modified Algae-Based Microrobot for Removal of SARS-CoV-2 in Wastewater

ACE2 Receptor-Modified Algae-Based Microrobot for Removal of SARS-CoV-2 in Wastewater

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

Exploring the therapeutic potential of marine-derived bioactive compounds against COVID-19

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