Can allergy patch tests with food additives help to diagnose the cause in childhood chronic spontaneous urticaria?

Özçeker, Deniz; Dilek, Fatih; Yücel, Esra; Tamay, Zeynep; Õzkaya, Emin; Güler, Nermin

doi:10.5114/ada.2020.96909

Cited by 5 publications

(9 citation statements)

References 24 publications

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“…In all the patients with positive OC, carmine patch tests were definitely negative, so we did not find any contact allergy coexistence. Other authors showed positive carmine patch tests in children, however no oral challenge was performed [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Carmine allergy in urticaria patients

Sadowska¹,

Sztormowska²,

Gawinowska³

et al. 2022

pdia

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Introduction Carmine, a commonly used natural red dye, can cause immediate and delayed allergic reactions, which are frequently overlooked. Aim To assess the incidence of carmine allergy and its clinical significance based on the placebo-controlled oral challenge in urticaria patients and suspected hypersensitivity to food additives. Material and methods Patients’ histories were recorded by means of a standardized questionnaire. The subjects underwent skin prick tests and patch tests for carmine, while the level of specific IgE was measured in 52 patients. The patients with at least one positive carmine test or with suspected hypersensitivity to carmine were suggested to undergo a placebo-controlled oral challenge test. Results One hundred and ten patients were enrolled in the study. Carmine skin testing was positive in 22 patients: skin prick tests were positive in 17% ( n = 19), while patch tests were doubtful in 6% ( n = 6). In 25/52 patients, the level of specific IgE was min. 0.01 kU/l. Oral challenge was performed in 33 subjects. Allergy to carmine was diagnosed in 9 (8%) patients; all of them suffered from chronic inducible urticaria. Conclusions Carmine is a potential allergen in patients with chronic inducible urticaria especially with concomitant systemic symptoms. Skin tests and specific IgE level measurement may be helpful tools to diagnose E120 hypersensitivity.

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Section: Discussionmentioning

confidence: 99%

Carmine allergy in urticaria patients

Sadowska¹,

Sztormowska²,

Gawinowska³

et al. 2022

pdia

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“…The use of the PT technique with common aero- and food- allergens instead of the standard contact allergens, has also been reported. 17 This process, known as the atopy PT, demonstrated that 17 of 120 children with CSU (14.1%) were sensitized to food additives. The authors concluded that the atopy PT may be useful in CSU.…”

Section: Discussionmentioning

confidence: 99%

“…For example, it has been postulated that house dust mite allergens penetrate the stratum corneum and activate Langerhans and mast cells. 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

“…For example, it has been postulated that house dust mite allergens penetrate the stratum corneum and activate Langerhans and mast cells. 17,18 To further investigate the role of contact allergens in CSU, we compare here the yield of PT in a group of CSU patients and in a large control group consisting of patients referred for evaluation of suspected allergic contact dermatitis.…”

Section: Introductionmentioning

confidence: 99%

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Role of Patch Testing in Chronic Spontaneous Urticaria

J¹,

Godlewicz²,

Ingber³

et al. 2021

JAA

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“…Food additives are natural or synthetic agents such as dyes, preservatives, and artificial sweeteners, which can act as potent pseudoallergens (Table 5). 44 A recent study has highlighted Azorubine and Cochineal red to be the food additives with the highest sensitivity 45 . Most food additives are excluded as part of PAF diets.…”

Section: Elimination Dietsmentioning

confidence: 99%

Dietary strategies for chronic spontaneous urticaria: an evidence‐based review

2021

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Although the relationship between diet and chronic spontaneous urticaria (CSU) remains elusive, several patients seek dietary modifications as they are easy and cost-effective.Adequate patient education and counseling are crucial as modified diets may be beneficial for a subset of antihistamine refractory CSU patients, and no modality currently exists to identify these patients. Elimination of food items based exclusively on patient history may lead to unnecessary restrictions in most cases resulting in nutritional deficiencies and impaired quality of life. Several dietary strategies have been tried till date with varying rates of success and evidence. This review highlights the various dietary strategies along with their levels of evidence, which may help the treating dermatologists and physicians to counsel CSU patients and make evidence-based treatment decisions. There is grade A recommendation for the elimination of food additives (artificial pseudoallergens), personalized diets, vitamin D supplementation, Diamine oxidase supplementation and probiotics (in children), grade B recommendation for dietary elimination of red meat, fish and their products, natural pseudoallergens (fruits, vegetables, and spices), and lowhistamine diet, while dietary elimination of gluten (with concomitant celiac disease) has grade C recommendation. Notably, elimination diets should be continued for at least 3 consecutive weeks to assess their effectiveness.

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Can allergy patch tests with food additives help to diagnose the cause in childhood chronic spontaneous urticaria?

Cited by 5 publications

References 24 publications

Carmine allergy in urticaria patients

Carmine allergy in urticaria patients

Role of Patch Testing in Chronic Spontaneous Urticaria

Dietary strategies for chronic spontaneous urticaria: an evidence‐based review

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