Can allogeneic haematopoietic cell transplantation be curative in classical Crohn's disease?

Abstract

Summary The article by Moser et al. details the outcomes of 11 patients with inflammatory bowel disease (IBD) as the main manifestation of their immune deficiency syndrome who are treated with allogeneic transplantation. The authors report low rates of complications (including graft‐versus‐host disease) and resolution of symptoms. Here we outline whether allogeneic transplantation should be considered more broadly for IBD. Commentary on: Moser et al. Treatment of inborn errors of immunity patients with inflammatory bowel disease phenotype by allogeneic stem cell transplantation. Br J Haematol 2023;200:595‐607.

Congenital pure red cell anemia and idiopathic very early onset of severe colitis cured by allogeneic hematopoetic stem cell transplantation

“…10 As HSCT is the only curative treatment for DBA and has been used for more than 40 years, 11,12 the indication for allogeneic HSCT as a treatment for IBD is more controversial, although, in general, HSCT is increasingly considered in severe immunodeficiency with associated IBD symptoms. [13][14][15][16] In our case, no pathogenic variants were found (see Supporting Material S1), and although it seems unlikely that two such rare conditions were caused by two independent events, no causative correlation was revealed.…”