Can anesthetic techniques or drugs affect cancer recurrence in patients undergoing cancer surgery?

Niwa, Hidetomo; Rowbotham, David J.; Lambert, David G.; Buggy, Donal J.

doi:10.1007/s00540-013-1615-7

Cited by 45 publications

(34 citation statements)

References 92 publications

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“…The benefits may be due to the attenuation of immunosuppression by regional anesthesia (12,22). Some in vitro animal data demonstrate that opioids promote tumor growth and metastasis, largely by inducing mitogenesis and angiogenesis (23,24). Regional anesthesia, in part, reduces the use of opioids, and thus may reduce tumor recurrence and improve survival.…”

Section: Discussionmentioning

confidence: 99%

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Wang

Jiang

et al. 2016

J. Thorac. Dis.

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Background: A retrospective analysis of patients undergoing cancer surgery suggested that using local anesthetics could reduce cancer recurrence and improve survival rate. Previous studies have indicated that local anesthetics may induce apoptosis in several kinds of cells in vitro, but the mechanism is unclear. Methods: Cell viability was analyzed by MTS; reactive oxygen species (ROS), mitochondrial membrane potential (MMP, ∆Ψm), cell cycle distribution, and cell apoptosis assay were detected by flow cytometry; DNA damage was measured by comet assay; cell invasion and migration were observed by microscopy; The expression level of related proteins was detected by western blot assay. Results: The results indicated that lidocaine and ropivacaine could decrease viability, induce G0/G1 phase arrest and apoptosis in human non-small cell lung cancer (NSCLC) cells A549 and H520. Invasion and migration were suppressed. Western blot indicated the related apoptotic pathways proteins changed accordingly. Additionally, lidocaine and ropivacaine downregulated ∆Ψm, provoked DNA damage, upregulated ROS production and activated mitogen-activated protein kinase (MAPK) pathways in A549 and H520 cells. Conclusions:The cytotoxic effect of amide-linked local anesthetics on NSCLC cells were mainly due to apoptosis. The antitumor mechanism of lidocaine and ropivacaine may involve apoptotic pathways and MAPK pathways.

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Section: Discussionmentioning

confidence: 99%

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Wang

Jiang

et al. 2016

J. Thorac. Dis.

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“…Cancer is a chronic degenerative disease considered to be the second most common cause of death in economically developing countries [1, 2]. According to a recent report by the International Agency for Research on Cancer (IARC), there are currently more than 10 million cases of cancer per year worldwide.…”

Section: Introductionmentioning

confidence: 99%

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Calderon

Sobrinho

Zaqueo

et al. 2014

BioMed Research International

166

149

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For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their components as antitumoral agents. Over the last few years, we have studied the effects of snake venoms and their isolated enzymes on tumor cell cultures. Some in vivo assays showed antineoplastic activity against induced tumors in mice. In human beings, both the crude venom and isolated enzymes revealed antitumor activities in preliminary assays, with measurable clinical responses in the advanced treatment phase. These enzymes include metalloproteases (MP), disintegrins, L-amino acid oxidases (LAAOs), C-type lectins, and phospholipases A2 (PLA2s). Their mechanisms of action include direct toxic action (PLA2s), free radical generation (LAAOs), apoptosis induction (PLA2s, MP, and LAAOs), and antiangiogenesis (disintegrins and lectins). Higher cytotoxic and cytostatic activities upon tumor cells than normal cells suggest the possibility for clinical applications. Further studies should be conducted to ensure the efficacy and safety of different snake venom compounds for cancer drug development.

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“…Cancer is a leading cause of mortality worldwide (1,2). Globally, it is estimated that there are currently >10 million cases of cancer diagnosed per year and that there will be ~13.1 million cases of cancer-associated mortality per year by 2030 (3).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and apoptotic activities of black widow spiderling extract against HeLa cells

Dai

Lei

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Black widow spiders contain toxic components not only in the venom glands but also in other parts of the spider body, including the legs and abdomen. Additionally, both the eggs and newborn spiderlings of the black widow spider contain venom. It is important to investigate their potential effects on cancer cells. In the present study, the effects of newborn black widow spiderling extract on human HeLa cells were evaluated in vitro. When applied at different concentrations, the total extract decreased HeLa cell viability in a dose-dependent manner, with an IC 50 value of 158 µg/ml. Flow cytometry indicated that treatment of HeLa cells with the total extract of the spiderlings induced apoptosis in HeLa cells in a dose-dependent manner and led to cell cycle arrest in the S-phase. Additionally, application of the total extract at different concentrations increased apoptosis-related caspase 3 activity in a dose-dependent manner. HeLa cells treated with the total extract appeared to be morphologically changed, exhibiting membrane blebbing, nuclear fragmentation and condensation of chromatin. Further separation and activity screening demonstrated that the cytotoxic and apoptotic activities of the total extract were attributable mainly to its high molecular mass proteins, one of which was purified and characterized to determine its anti-tumor activities on HeLa cells. The results of the present study therefore have expanded understanding regarding the effect of spider toxins on cancer cells and suggested that components of black widow spiderlings may be developed as a promising novel agent to treat cancer.

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Can anesthetic techniques or drugs affect cancer recurrence in patients undergoing cancer surgery?

Cited by 45 publications

References 92 publications

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

Cytotoxic and apoptotic activities of black widow spiderling extract against HeLa cells

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