Can antibiotics be harmful in atopic dermatitis?

Leung, Donald Y.M.

doi:10.1111/bjd.17023

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…34 All of these can aggravate already inflamed skin, and in several studies the use of antimicrobials and medicated shampoos has been found to be beneficial in combination with other treatments for AD, 37,38 however, there is concern about increasing resistance of bacteria with the continued use of antibiotics. 39 As with epidermal barrier dysfunction, changes in microbiota community diversity and prevalence might be primary or secondary to AD development.…”

Section: Immunopathologymentioning

confidence: 99%

Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies

Drechsler,

Dong,

Clark

et al. 2024

VMRR

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Atopic dermatitis (AD) is a common inflammatory and pruritic allergic skin disease in humans and dogs worldwide. The pathogenesis of AD is multifactorial, immunologically complex, and may involve genetic factors, epidermal barrier dysfunction, microbiome changes, immune dysregulation, and allergic sensitization. Across species, prevalence of AD is on the rise. At present, there is no cure for canine AD (CAD). The treatment for CAD is multifaceted and aimed at controlling the pruritus, associated inflammation, and infections, repairing the skin barrier function, and dietary management. This review presents data on prevalence, impact, and complex immunological interactions in AD with a focus on subsequent management of the disease in the canine population. A multimodal approach for management of CAD to address varying clinical signs and responses to therapies is discussed.

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Section: Immunopathologymentioning

confidence: 99%

Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies

Drechsler,

Dong,

Clark

et al. 2024

VMRR

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show abstract

“…In essence, resistant strains to decolonization by fusidic acid and mupirocin are increasingly reported [152]. As a consequence, the lack of therapeutic efficacy with the emergence of these resistant strains has underscored the importance of avoiding the long-term use of topical or systemic antimicrobial in AD [153].…”

Section: Admentioning

confidence: 99%

Herbal Bioactive Compounds for Skin Infections and Inflammatory Conditions

Tirant,

Wollina

2024

Open Access Maced J Med Sci

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Skin microbiota is an integral part of the human immune system. Staphylococcus aureus is one of the essential components of the normal flora. Approximately 20–30% of healthy individuals are persistently colonized with S. aureus, whereas the remainders are considered low-level intermittent carriers. Despite these natural aspects of existence, S. aureus can be a major opportunistic human pathogen. This versatile microorganism can infect a variety of anatomical sites, causing a broad spectrum of pathologies ranging from superficial to invasive infections. It developed a variety of strategies to adopt to a changing microenvironment. This attributed to the emergence of resistance to antibiotics of different classes during the past six decades. Methicillin-resistant S. aureus (MRSA) was originally confined to health-care settings (health-care-associated MRSA). Later on, community-acquired MRSA was identified as another source of infections. Recent figures indicate that MRSA strains have been associated with approximately 75% of all S. aureus infections worldwide. Several guidelines have been published to establish an adequate treatment of skin and soft tissue infections (SSTIs) caused by MRSA strains. In the first part of this review, we focus on current treatment guidelines with a focus on medical drug therapy, but drug therapy has its own limitations. Recently, the interest in herbal remedies has greatly increased. There is growing evidence of antimicrobial activity of medicinal plants and their extracts. The second part of this review is dedicated to herbal compounds to circumvent antibiotic resistance. Herbal compounds may potentiate the action of antibiotics and restore the activities of antibacterial agents against which S. aureus has developed a drug resistance. Part 2 focuses on the role of S. aureus in pathology of the two major inflammatory skin diseases, i.e., atopic dermatitis (AD) and psoriasis. Finally, Part 3 provides an overview on natural compounds with antimicrobial activity against S. aureus and possible use in the treatment of SSTIs,

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“…The use of topical antibiotics for skin infections is not a new concept, and common antibiotics such as mupirocin are regularly used for skin infections caused by staphylococci. Skin diseases associated with S. aureus colonization including atopic dermatitis (AD) often use this treatment method as colonization with this species results in disease exacerbation and skin barrier dysfunction ( 39 – 41 ). Antibiotics have been shown to decrease the severity of AD, however, there are increasing reports of antimicrobial resistance in S. aureus strains isolated from patients with AD ( 42 – 44 ).…”

Section: Current Treatment Options For Ak and Csccmentioning

confidence: 99%

Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?

Bromfield

Hugenholtz²,

Frazer³

et al. 2023

Front. Oncol.

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Cutaneous squamous cell carcinoma (cSCC) and its premalignant precursor, actinic keratosis (AK), present a global health burden that is continuously increasing despite extensive efforts to promote sun safety. Chronic UV exposure is a recognized risk factor for the development of AK and cSCC. However, increasing evidence suggests that AK and cSCC is also associated with skin microbiome dysbiosis and, in particular, an overabundance of the bacterium Staphylococcus aureus (S. aureus). Studies have shown that S. aureus-derived toxins can contribute to DNA damage and lead to chronic upregulation of proinflammatory cytokines that may affect carcinogenesis. Eradication of S. aureus from AK lesions and restoration of a healthy microbiome may therefore represent a therapeutic opportunity to alter disease progression. Whilst antibiotics can reduce the S. aureus load, antibiotic resistant S. aureus pose an increasing global public health threat. The use of specific topically delivered probiotics has been used experimentally in other skin conditions to restore eubiosis, and could therefore also present a non-invasive treatment approach to decrease S. aureus colonization and restore a healthy skin microbiome on AK lesions. This article reviews mechanisms by which S. aureus may contribute to cutaneous carcinogenesis, and discusses hypotheses and theories that explore the therapeutic potential of specific bacterial species which compete with S. aureus in an attempt to restore microbial eubiosis in skin.

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Can antibiotics be harmful in atopic dermatitis?

Abstract: Linked Article: Harkins et al. Br J Dermatol 2018; 179:951–958.

Cited by 3 publications

References 10 publications

Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies

Canine Atopic Dermatitis: Prevalence, Impact, and Management Strategies

Herbal Bioactive Compounds for Skin Infections and Inflammatory Conditions

Targeting Staphylococcus aureus dominated skin dysbiosis in actinic keratosis to prevent the onset of cutaneous squamous cell carcinoma: Outlook for future therapies?

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