Can bioactive peptides of Lagocephalus sceleratus be evaluated in the functional food industry

Çavaş, Levent; Bilgin, Yağmur; Yılmaz-Abeşka, Yeşim

doi:10.38042/biost.2020.29.02.04

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…This study appears partly to confirm the findings of our study. Cavas et al (2020), in our previous study, proposed that the toxins of Lagocephalus sceleratus can be removed and the residues including toxins could be exploited in some industries such as pharmacy inasmuch as their analgesic and anti-cancer effects have been reported for these toxins. From the study of Cavas et al (2020), it could be said that the removed toxins of L. sceleratus may also be evaluated in different industries such as pharmacy inasmuch as their analgesic and anti-cancer effects.…”

Section: Discussionmentioning

confidence: 99%

Bioactivities from Novel Toxins of Pterois volitans: A Bioinformatics Approach

Çavaş

Bilgin

2021

Gazi University Journal of Science Part A: Engineering and Innovation

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Pterois volitans (Linnaeus, 1758), native of the Indo-Pacific Ocean, is an invasive fish species in the Western-Atlantic. Due to the very long venomous spines, they increase their populations in newly invaded habitats. No validated eradication method has been existed for this species yet. Therefore, there is an urgent need for alternative utilization methods for this fish species. Bioactive peptides are of great importance for human health since they exhibit excellent inhibitory properties for some medicinally important enzymes in human metabolisms such as angiotensin converting enzyme (ACE) and dipeptidyl peptidase-IV (DPP-IV). In this study, the bioactive peptides in protein-based venom of P. volitans, Pvtoxin-a and Pvtoxin-b, were investigated by using in silico tools. Total number of negatively charged residues (Asp + Glu) for Pvtoxin-a and Pvtoxin-b were found as 21 and 18, respectively. Total number of positively charged residues (Arg + Lys) for Pvtoxin-a and Pvtoxin-b were observed to be 22 and 24, respectively. According to BIOPEP results, AE values for ACE and DPP-IV were found to be 0.0305 and 0.0666 for Pvtoxin-a and Pvtoxin-b as 0.0333 and 0.0569, respectively. It is very interesting to note that AE values related to antioxidant property were observed to be 0.0083 for both Pvtoxin-a and Pvtoxin-b. Although AE value for alpha-glucosidase inhibitor was found to be 0.0014 for Pvtoxin-a, no AE value was obtained for Pvtoxin-b. In conclusion, the BIOPEP results clearly show that after a possible eradication study, protein-based venoms from P. volitans can be evaluated in the production of bioactive peptides. A possible economical value may create a pressure on its increasing population in newly invaded areas.

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Section: Discussionmentioning

confidence: 99%

Bioactivities from Novel Toxins of Pterois volitans: A Bioinformatics Approach

Çavaş

Bilgin

2021

Gazi University Journal of Science Part A: Engineering and Innovation

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Marine invasive alien species in Europe: 9 years after the IAS Regulation

Katsanevakis,

Olenin,

Puntila-Dodd

et al. 2023

Front. Mar. Sci.

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Biological invasions, resulting from human activities, exert substantial impacts on ecosystems worldwide. This review focuses on marine invasive alien species (IAS) in Europe, examining the current state, proposing strategies to address the problem, and offering recommendations for enhanced management. Effective management of biological invasions relies on accessible, accurate data to inform decision-making. Information systems such as the European Alien Species Information Network (EASIN), Aquatic Non-Indigenous and Cryptogenic Species (AquaNIS), and World Register of Introduced Marine Species (WriMS) provide comprehensive databases on IAS, but their sustainability requires long-term maintenance, continuous updates, and support. Most countries lack specific monitoring programs for marine IAS, and standardization and improvement of monitoring methods are needed. Port monitoring plays a vital role in the early detection of new arrivals, and recent advancements in molecular techniques show promise for effective IAS monitoring. Risk screening tools are commonly employed to rank taxa based on their invasiveness potential in European regions, but variations in protocols can yield inconsistent results. European impact assessments highlight resource competition, novel habitat creation, and predation as primary mechanisms for negative impacts on biodiversity, while the creation of novel habitats represents a key mechanism for positive impacts. Preventing IAS introductions is critical, and measures such as ballast water treatment systems are implemented to reduce the likelihood of marine introductions. However, understanding introduction pathways remains uncertain for many IAS. Eradication and control efforts for marine IAS have limited success, emphasizing the need for enhanced biosecurity measures. Climate change, especially ocean warming, can intensify IAS impacts on native species and ecosystems. In climate change hotspots, some tropical aliens may, however, compensate for the loss of thermally sensitive natives with similar traits. Therefore, it is imperative to consider the interactions between climate change and IAS in developing effective management and conservation strategies. Enhancing IAS management in Europe entails i) securing adequate funding, ii) expanding the list of IAS of Union Concern to adequately cover marine invasions, iii) learning from countries with successful biosecurity practices, iv) sustaining information systems, v) improving monitoring and early warning systems with innovative technologies, vi) enhancing prediction models, vii) conducting integrated impact assessments and mapping cumulative IAS impacts, and vii) considering the potential benefits of IAS in ecosystem functioning and services.

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Investigation of bioactive peptides from Scolymus hispanicus by using in silico methods

Çavaş,

Dogmaz,

Kandemir Çavaş

2024

Bulletin of Biotechnology

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Due to increases in the soil pollution related to agricultural areas, the interests on the wild edible greens have been increasing nowadays. Scolymus hispanicus (=Golden thistle) is a wild edible plant which is widely and naturally spread in Türkiye. An in silico-based bioinformatics approach has been proposed for the evaluation of bioactive peptides from this species. In silico digestion and also bioactive peptides of RubisCO from S.hispanicus were studied by using BIOPEP-UWM. Protparam and Clustal Omega were also used to determine physicochemical parameters and sequence similarity, respectively. The AE values related to angiotensin converting enzyme and dipeptidyl peptidase-IV were 0.0847 and 0.1059 after in silico pepsin digestion (pH>2), respectively. While the antioxidant property obtained after pepsin (pH>2) digestion was found to be 0.0127, the value of 0.042 was obtained for ficin on this parameter. BIOPEP-UWM also exhibit important properties related to the bioactivities of the peptides such as antioxidant, dipeptidyl peptidase-IV and angiotensin converting enzyme inhibitions. From the results, it could be said that S. hispanicus has very important bioactive peptides which could be evaluated in the production of functional foods. Moreover, isolated bioactive peptides and also secondary metabolites can also be utilized in pharmaceutical industry. Further in vitro and in vivo studies are strongly recommended on S. hispanicus.

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Can bioactive peptides of Lagocephalus sceleratus be evaluated in the functional food industry

Cited by 3 publications

References 44 publications

Bioactivities from Novel Toxins of Pterois volitans: A Bioinformatics Approach

Bioactivities from Novel Toxins of Pterois volitans: A Bioinformatics Approach

Marine invasive alien species in Europe: 9 years after the IAS Regulation

Investigation of bioactive peptides from Scolymus hispanicus by using in silico methods

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