Can Bladder Wall Thickness Predict Videourodynamic Findings in Children with Spina Bifida?

Kim, Woo Jin; Shiroyanagi, Yoshiyuki; Yamazaki, Yoji

doi:10.1016/j.juro.2015.03.002

Cited by 16 publications

(9 citation statements)

References 10 publications

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“…Kim et al 11 in their study on the role of BWT in predicting urodynamic findings, opined that there were no significant differences in BWT measured at each percent maximum cystometric capacity between patients with favorable or unfavorable video urodynamic findings. This could imply that BWT alone cannot be relied upon as a marker for the assessment of NB.…”

Section: Discussionmentioning

confidence: 99%

TIMP‐2 as a noninvasive urinary marker for predicting neurogenic bladder in patients under follow‐up for spina bifida

Nayak

Bawa

Kanojia

et al. 2020

Neurourology and Urodynamics

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Introduction: Neurogenic bladder (NB) post-meningomyelocele (MMC) repair is a major challenge and needs lifelong follow-up. Many cytokines have been implicated in the pathogenesis of NB. To avoid repeated urodynamic studies (UDS) and renal scans, we studied urinary tissue inhibitors of metalloproteinases-2 (TIMP-2) levels and correlated with urodynamic profiles to establish their efficacy. Materials and Methods: Prospective case-control study on children between 6 months to 12 years of age, who were at least 6 months post-MMC repair and had NB on UDS. Patients were evaluated under 4 cohorts of 20 patients each: Group A (NB on treatment), Group B (NB not on treatment), Group C (no NB), and Group D (Controls). All groups underwent radiofrequency thermocoagulation, urine culture, ultrasonography. Urine samples were stored at −8°C and analyzed using a validated Human ELISA kit for TIMP-2. Results: Eighty patients with a mean age of 3.54 ± 2.1 years were studied. A common ultrasound finding was a thickened urinary bladder (33.3%). All UDS parameters showed a statistically significant differences between groups with NB (Groups A and B) and a group without NB (Group C). Analysis of TIMP-2 levels between individual groups was statistically significant. The area under the receiver operating characteristic curve between urinary TIMP-2 and cystometric parameters indicated that urinary TIMP-2 levels are highly diagnostic of NB. TIMP-2 value of 358.5 pg/ml was found to be the least value with 93.5 sensitivity and 86.2% specificity. Conclusion: This study highlights the potential of urinary marker TIMP-2 as noninvasive and cost-effective test to initially diagnose and predict the progression of disease in NBs with reasonable sensitivity and specificity.

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Section: Discussionmentioning

confidence: 99%

TIMP‐2 as a noninvasive urinary marker for predicting neurogenic bladder in patients under follow‐up for spina bifida

Nayak

Bawa

Kanojia

et al. 2020

Neurourology and Urodynamics

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“…Nevertheless, low compliance is a critical factor widely recognized as dangerous for the upper tracts and the term is freely used in literature and textbooks. [ 22 ] Contemporary studies have defined “low compliance” variously as <10 ml/cmH 2 O,[ 26 ]< 12.5 ml/cmH 2 O,[ 20 27 ] or <20 ml/cmH 2 O. [ 28 ] Others have stated the actual values noted without defining “low compliance.”[ 29 ] We chose to provide both the actual data as well as a defined numerical value for “low compliance.” A bimodal age distribution has been described with most children identified in infancy and the remainder by age five.…”

Section: Discussionmentioning

confidence: 99%

Symptomatic lower urinary tract dysfunction in sacral agenesis: Potentially high risk?

2018

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Introduction:Sacral agenesis (SA) is a caudal regression anomaly that can cause neurogenic bladder but is not generally recognized as high risk. We studied the clinical presentation, upper urinary tract, bone and spine abnormalities, and urodynamic findings in patients with SA and compared them with related high-risk conditions, anorectal malformation (ARM), and cloacal malformation.Materials and Methods:Patient records between May 2011 and December 2015 were identified and grouped into isolated SA without an overt anomaly (Group I), SA with overt caudal regression anomalies (Group II), and ARM or cloacal malformation without the SA (Group III). Distribution of clinical and urodynamic findings and factors associated with reduced eGFR were tested with rank sum test, t-test, and unadjusted odds (P < 0.05 significant) using R statistical program (version 3.1.3).Results:Of 605 neurogenic bladder patients treated in the study period, 39 fulfilled the inclusion criteria. 12 were Group I, 5 Group II, and 22 Group III. Long-standing lower urinary symptoms were noted in all SA patients. Group I patients were older (14.5 years vs. 6 years and 5 years for II and III). Patients with SA (Group I and II) had poor compliance (6.7 ml/cmH2O, interquartile range [IQR] 4–13.6 ml/cmH2O), reduced age-adjusted bladder capacity (59%, IQR 22–85%), elevated end-fill pressure (22 cmH2O, IQR 11–28 cmH2O), hydronephrosis (88%), and reduction in eGFR (29%), all comparable to Group III. Most had Renshaw type II SA and tethered spinal cord rather than wedge-shaped termination. Limitations include small numbers and significant selection bias.Conclusions:Symptomatic neurogenic bladder due to SA may cause renal damage similar to ARM but often eludes diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Attempts to correlate with ultrasonography findings with function have been unsuccessful, but did establish and association between bladder wall thickness and the presence of trabeculations when the bladder is at greater than 50% of filling capacity. 17 Although the pathogenesis is unclear, response to treatment may depend on the presence of SBO. One study of children with nocturnal enuresis showed that none of the children with SBO had a response to desmopressin, defined as 90% or better improvement in the frequency of nocturnal bedwetting compared with the children without SBO.…”

Section: Discussionmentioning

confidence: 99%

Enuresis and Constipation in a 12-Year-Old

Schwartz¹,

Hillman²,

Omoruyi³

et al. 2017

Clin Pediatr (Phila)

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Can Bladder Wall Thickness Predict Videourodynamic Findings in Children with Spina Bifida?

Abstract: Even if bladder wall thickness is measured at specifically defined bladder volumes, it cannot predict videourodynamic findings other than bladder trabeculation in children with spina bifida.

Cited by 16 publications

References 10 publications

TIMP‐2 as a noninvasive urinary marker for predicting neurogenic bladder in patients under follow‐up for spina bifida

TIMP‐2 as a noninvasive urinary marker for predicting neurogenic bladder in patients under follow‐up for spina bifida

Symptomatic lower urinary tract dysfunction in sacral agenesis: Potentially high risk?

Enuresis and Constipation in a 12-Year-Old

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