Can breathing circuit filters help prevent the spread of influenza A (H1N1) virus from intubated patients?

Heuer, Jan Florian; Crozier, T. A.; Howard, G. A.; Quintel, Michael

doi:10.3205/dgkh000209

GMS Hygiene and Infection Control; 8(1):Doc09; ISSN 2196-5226 2013

DOI: 10.3205/dgkh000209

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Can breathing circuit filters help prevent the spread of influenza A (H1N1) virus from intubated patients?

Jan Florian Heuer

T. A. Crozier²,

G. A. Howard³

et al.

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Cited by 7 publications

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“…On the other hand, viral RNA was detected in a number of cases (33/55, 60.0%) in the patient side of the BB100 device. Similarly, Heuer and collegues 7 documented that three filters retained H1N1 influenza virus input in an air stream model. Interestingly, when the BAL viral load was >10 5 copies per ml, most filters (23/25, 92.0%, 95% CI 76.7-98.3%) were positive for SARS-CoV-2, while when the viral load was ≤10 5 copies per ml only 9/29 (31.0%, 95% CI 16.6-49.0%) filters were positive (p<0.001).…”

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confidence: 90%

SARS-CoV-2 viral load in heat and humidity exchange filters during invasive mechanical ventilation of patients with COVID-19

Fulceri

Morecchiato

Antonelli

et al. 2022

British Journal of Anaesthesia

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mentioning

confidence: 90%

SARS-CoV-2 viral load in heat and humidity exchange filters during invasive mechanical ventilation of patients with COVID-19

Fulceri

Morecchiato

Antonelli

et al. 2022

British Journal of Anaesthesia

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Opportunities for biomaterials to address the challenges of COVID‐19

Chakhalian

Shultz

Miles

et al. 2020

J Biomedical Materials Res

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The coronavirus disease 2019 (COVID‐19) pandemic has revealed major shortcomings in our ability to mitigate transmission of infectious viral disease and provide treatment to patients, resulting in a public health crisis. Within months of the first reported case in China, the virus has spread worldwide at an unprecedented rate. COVID‐19 illustrates that the biomaterials community was engaged in significant research efforts against bacteria and fungi with relatively little effort devoted to viruses. Accordingly, biomaterials scientists and engineers will have to participate in multidisciplinary antiviral research over the coming years. Although tissue engineering and regenerative medicine have historically dominated the field of biomaterials, current research holds promise for providing transformative solutions to viral outbreaks. To facilitate collaboration, it is imperative to establish a mutual language and adequate understanding between clinicians, industry partners, and research scientists. In this article, clinical perspectives are shared to clearly define emerging healthcare needs that can be met by biomaterials solutions. Strategies and opportunities for novel biomaterials intervention spanning diagnostics, treatment strategies, vaccines, and virus‐deactivating surface coatings are discussed. Ultimately this review serves as a call for the biomaterials community to become a leading contributor to the prevention and management of the current and future viral outbreaks.

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A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microspheres

Brustowicz

Yuki

2020

Pediatric Anesthesia

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Background During the corona virus pandemic, preventing contamination of the anesthesia machine, critical to avoid cross‐contamination between patients, has proven challenging when treating premature infants and neonates. While attaching a HEPA filter to the endotracheal tube will protect the anesthesia machine and the gas sampling line from contamination, this contributionto the dead space makes ventilation of these small patients challenging. Direct filtration of the gas sampling line eliminates this problem;however, appropriate filters are not readily available. Aims Identify a small filter capable of filtering outparticles of a size similar to the SARS‐CoV‐2 virus for the gas sampling line. Methods We used fluorescence microspheres suspended in a solution for a challenge test to determine the filtration efficiency of various filters. The microspheres varied in diameter (0.02 µm, 0.042 µm, 0.109 µm and 0.989 µm). A fluorescence plate reader was used to evaluate the degree of fluorescence intensity in the flow‐through from various filters and referenced to the fluorescence intensity of the input. Results AHEPA filter,as recommended as an anti‐viral filter, effectively filtered all the particles tested. The B. Braun PERIFIX Flat Epidural Filter was the second most effective filter, filtering particleslarger than 0.042 µm.Other filters tested did not filter fluorescence microspheres equivalent in size to a single coronavirus particle (0.07 µm). Conclusions Although the Food and Drug Administration (FDA) has not approved the Flat Epidural Filter for use as an anesthesia machine gas filter, our simple challenge test suggests that it could be used to effectively filter the anesthesia gas sampling line.

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Can breathing circuit filters help prevent the spread of influenza A (H1N1) virus from intubated patients?

Cited by 7 publications

References 16 publications

SARS-CoV-2 viral load in heat and humidity exchange filters during invasive mechanical ventilation of patients with COVID-19

SARS-CoV-2 viral load in heat and humidity exchange filters during invasive mechanical ventilation of patients with COVID-19

Opportunities for biomaterials to address the challenges of COVID‐19

A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microspheres

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