Can childhood asthma be predicted at birth?

Carlsen, Kai‐Håkon; Mowinckel, Petter; Granum, Berit; Carlsen, Kai‐Håkon

doi:10.1111/j.1365-2222.2010.03620.x

Cited by 10 publications

(16 citation statements)

References 42 publications

(74 reference statements)

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“…Lundholm et al [105] demonstrated that increasing birth weight is a risk factor for AD, but not AR, clearly independent of gestational age, shared environmental and genetic factors. This indicates that fetal growth affects the immune system and points to early mechanisms in line with evidence from many birth cohort studies [79, 106–111]. Thomsen et al [112] confirmed the strong genetic component of asthma in children and adults, and that this may not extend to older adults.…”

Section: Epidemiology Of Allergic Diseasessupporting

confidence: 64%

Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Katelaris

Linneberg

Magnan

et al. 2011

Clin Experimental Allergy

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In 2010 over 200 articles were published in Clinical and Experimental Allergy including editorials, reviews, opinion articles, letters, book reviews and of course at the heart of the journal, papers containing original data which have moved the field of allergy forward on a number of fronts. For the third year running the editors felt it would be of value to summarize the key messages contained in these papers as a snapshot of where the cutting edge of research into allergic disease is leading. We have broadly followed the sections of the journal, although this year the mechanistic articles are grouped together and the studies involving experimental models of disease are discussed throughout the paper. In the field of asthma and rhinitis phenotypes and biomarkers continue to a major pre-occupation of our authors. There is continued interest in mechanisms of inflammation and disordered lung function with the mouse model of asthma continuing to offer new insights. There is also a steady flow of papers investigating new therapies, including those derived from plants and herbs, although many are mechanistic with too few high quality clinical trials. The mechanisms involved in allergic disease are well covered with many strong papers using clinical material to ask relevant questions. Pro-pre and snybiotics continue to be of major interest to our authors and this remains a controversial and complicated field. The discipline of epidemiology has retained its interest in risk factors for the development of allergic disease with a view to refining and debating the reasons for the allergy epidemic. There is continued interest in the relationship between helminthic disease and allergy with a new twist in 2010 involving studies using infection with helminths as a potential treatment. The genetics of allergic disease continues to be very productive, although the field has moved on from only investigating single nucleotide polymorphisms of candidate genes to Genome Wide Association Studies and an increasing and welcome emphasis on gene-environment interactions. In the field of clinical allergy there is steady flow of papers describing patterns of drug allergy with renewed interest in reactions to contrast media, but food allergy is the major area of interest in this section of the journal. Lastly in the field of allergens there is a growing interest in the role of component resolved diagnosis in improving the diagnosis and management of allergic disease. Another excellent year, full of fascinating and high quality work, which the journal has been proud to bring to the allergy community.

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Section: Epidemiology Of Allergic Diseasessupporting

confidence: 64%

Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Katelaris

Linneberg

Magnan

et al. 2011

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…However, these results might be biased by the administration of corticosteroids during the acute stage which might have caused suppression of cell activation, thereby reducing sCD14 levels in serum [49]. Multiple studies showed no association of sCD14 levels with asthma as measured in cord blood, serum or bronchoalveolar lavage fluid [23,50,51]. In one study no association of sCD14 levels in breast milk with wheeze was found [52].…”

Section: Resultsmentioning

confidence: 99%

A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Klaassen

Thönissen

Eys

et al. 2013

All Asth Clin Immun

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The aetiology of childhood asthma is complex. An early dysfunction in the immunological development of the innate immune system in combination with environmental factors possibly triggers asthma. CD14 and toll-like receptors are important components of the innate immune system. The aim of this systematic review was to obtain a better insight into the relation between CD14 and toll-like receptors and childhood asthma in Caucasians. We searched PubMed and EMBASE for relevant articles. In total, 44 articles were included. The quality of the selected studies was independently assessed by the first two authors using the Newcastle-Ottawa quality assessment scale. Toll-like receptor 2, toll-like receptor 6, toll-like receptor 9, and toll-like receptor 10 appear to have some association with childhood asthma in Caucasians. The evidence for a relation of CD14 with childhood asthma is limited. In conclusion, there is no convincing evidence yet for a role of CD14 and toll-like receptors in relation to childhood asthma. Future studies should include haplotype analysis and take environmental factors into account to further clarify the role of CD14 and toll-like receptors on childhood asthma.

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“…The article in this issue of the journal by Lødrup Carlsen et al [9] has extended the investigation of this hypothesis further, by trying to predict who will develop asthma from information gathered at the time of birth. Using an extraordinary database on over 600 healthy babies, which includes lung function tests carried out in the first few days of life, they identify which factors predict who will develop asthma, allergic rhinitis and the absence of either condition by age 10.…”

mentioning

confidence: 99%

“…Although the resulting risk factor models developed by Lødrup Carlsen et al [9] were statistically significant for predicting asthma, rhinitis and ‘healthy’ (the absence of these diseases and negative skin prick tests) by age 10, the predictive value of the models were disappointing. The best model could predict 75% of asthma by age 10, but had poor specificity.…”

mentioning

confidence: 99%