The activated sludge process is regarded by many as a remarkable engineering development of the 20th Century which has made a great contribution to wastewater treatment. But after more than 100 years of successful application, the conventional activated sludge (CAS) process has recently been receiving an increasing number of critiques due to the high energy consumption and excessive sludge generation associated with it. Increasing efforts have been devoted to energy recovery in the form of biogas produced from waste sludge through anaerobic digestion (AD). However, the recoverable electrical energy generated from the AD of waste sludge can only offset about 50-60% of the total input energy of wastewater treatment plants (WWTPs) with CAS as the core process, while energy efficiency could be increased further to about 75% with upgraded AD equipped with pre-treatment of thickening sludge and a combined heat and power (CHP) process (Cao, 2011). Moreover, process upgrading and retrofitting are urgently needed in more and more WWTPs around the world to meet the tightened effluent discharge standards applied in recent years which inevitably lead to a rising trend of in-plant energy consumption. For example, it has been reported that the effluent discharge standards in China have been gradually migrated to quasi Class IV for surface water bodies with very low discharge limits. Consequently, it appears almost impossible or highly challenging to