Can coconut oil and treadmill exercise during the critical period of brain development ameliorate stress-related effects on anxiety-like behavior and episodic-like memory in young rats?

Silva, Débora de Cássia da; Tavares, Maryane Gabriela; Nascimento, Camila Karina Brito do; Lira, Eduardo Carvalho; Amâncio-dos-Santos, Ângela; Maia, Luciana Maria; Hornsby, Manuella Batista-de-Oliveira

doi:10.1039/c7fo01516j

Cited by 11 publications

(15 citation statements)

References 34 publications

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“…However, none of the chronic effects of C10 reached the study‐wide statistical significance, and further study will be needed to confirm the findings of antidepressant effect. It has been recently reported that chronic treatment with a KD and MCT diet induced decreased anxiety‐ and depression‐like behaviors in rodents 8,9,11,12,27 . Our study suggests that C10 is one of the fatty acids partially contributing to the antidepressant‐like effects.…”

Section: Discussionsupporting

confidence: 57%

“…Acute injection of fatty acids, including one of the medium‐chain fatty acids, lauric acid (dodecanoic acid; C12), is suggested to contribute to a decrease in anxiety‐like behavior 10 . Chronic administration of coconut oil or MCT diet has also been reported to decrease anxiety‐like behaviors in rats 11,12 . These findings suggest that acute and chronic administrations of MCTs have anxiolytic and antidepressant effects.…”

Section: Introductionmentioning

confidence: 99%

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Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice

Shoji

Miyakawa

2022

Neuropsychopharm Rep

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Aim Capric acid (also known as decanoic acid or C10) is one of the fatty acids in the medium‐chain triglycerides (MCTs) commonly found in dietary fats. Although dietary treatment with MCTs is recently of great interest for the potential therapeutic effects on neuropsychiatric disorders, the effects of oral administration of C10 on behavior remain to be examined. This study investigated acute and chronic effects of oral administration of C10 on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice. Methods To explore the acute effects of C10 administration, mice were subjected to a series of behavioral tests in the following order: light/dark transition, open field, elevated plus maze, Porsolt forced swim, and tail suspension tests, 30 minutes after oral gavage of either vehicle or C10 solution (30 mmol/kg dose in Experiment 1; 0.1, 0.3, 1.0, 3.0 mmol/kg doses in Experiment 2). Next, to examine chronic effects of C10, mice repeatedly administered with either vehicle or C10 solution (0.3, 3.0 mmol/kg doses per day, for 21 days, in Experiment 3) were subjected to behavioral tests without oral administration immediately before each test. Results The mice administrated with the high dose of C10 (30 mmol/kg) showed lower body weights, shorter distance traveled, and more anxiety‐like behavior than vehicle‐treated mice, and the results reached study‐wide statistical significance. The C10 administration at a lower dose of 0.3 mmol/kg had no significant effects on body weights and induced nominally significantly longer distance traveled than vehicle administration. Repeated administration of C10 at a dose of 3.0 mmol/kg for more than 21 days caused lower body weights and decreased depression‐related behavior, although the behavioral differences did not reach study‐wide significance. Conclusions Although these results suggest dose‐dependent effects of oral administration of capric acid on locomotor activity and anxiety‐like and depression‐related behaviors, further study will be needed to replicate the findings and explore the underlying brain mechanisms.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice

Shoji

Miyakawa

2022

Neuropsychopharm Rep

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“…Importantly, coconut oil, which mainly contains LA [7], induces enhanced memory function and reduces the anxiety-like behavior though LA. However, it has lesser ability to produce astrocytic ketone bodies compared to caprylic acid [5,8,42]. Moreover, it has been demonstrated that coconut oil directly activates the neuronal ERK and Akt signaling to prevent amyloid β toxicity [6].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, MCFAs not only provide ketone bodies but also protect cortical neurons against amyloid β-induced toxicity [6]. Coconut oil, which contains a high amont of LA [7], prevents stress-induced depressive-and anxiety-like behaviors in rodents [8]. Although the beneficial effect of MCFAs is gradually being recognized, their effect on neuronal functions has not been well-understood.…”

Section: Introductionmentioning

confidence: 99%

Lauric acid promotes neuronal maturation mediated by astrocytes in primary cortical cultures

Nakajima

2020

Heliyon

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Previous studies have suggested the potential efficacy of middle chain fatty acids (MCFAs) in the treatment of mood disorders and cognitive dysfunction. MCFAs are metabolized to ketone bodies in astrocytes; however, their effects on neuronal development including neurotrophic factor level are not well-understood. In the present study, we examined the effect of MCFAs on the mRNA expression of growth factors and cytokines in primary cultures of cortical astrocytes. The effect of MCFAs on neuron-astrocyte interaction in neuronal maturation was also determined using co-culture and astrocyte-conditioned medium. Lauric acid (LA) typically increased the mRNA expression of glial-derived neurotrophic factor (Gdnf), interleukin-6 (Il6), and CC motif chemokine 2 (Ccl2) in astrocytes. LA-induced phosphorylation of extracellular signalregulated kinase contributed to these changes. In primary cultures of cortical neurons containing astrocytes, LA enhanced the presynaptic protein levels. Astrocyte-conditioned medium after LA treatment also enhanced the presynaptic protein levels in the cortical neuron cultures. These results suggest that LA increase the mRNA expression of GDNF and cytokines in astrocytes, and thereby, enhances the presynaptic maturation.

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“…The combined products were found to be almost twice as effective as the products in isolation. CO and exercise during lactation can ameliorate the effects of stress on anxiety-like behavior and episodic-like memory in young rats through evaluation cognitive test Mini-Mental State Examination for changes (da Silva et al, 2018).…”

Section: Effect Of Coconut In Treatment Of Diabetes and Hypertensionmentioning

confidence: 99%

Effects of coconut oil on Alzheimer disease

Al-Matrafi¹

2021

Int. j. adv. appl. sci.

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Dementia is a general term for loss of memory, language, problem-solving, and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's disease (AD) is the most common cause of dementia. Risk factors as age, genetics, environment, lifestyle, and metabolic disease. The etiology of AD remains not fully explained, but both genetic and environmental risk factors have been proposed to be involved. Microscopically, intraneuronal neurofibrillary tangles (NFTs) and extracellular senile plaques characterize the AD. The amyloid cascade hypothesis (ACH) suggests that the imbalance between the Amyloid-β generation and its clearance causes dysfunction and consequently cell death. Coconut oil may represent a cheap and natural treatment for AD. This is because coconut oil contains medium-chain triglycerides (MCTs), which are digested to ketones in the liver that are linked to mitochondrial function enhancement and oxidation-reduction. Recent studies have investigated the possibility of using trans-zeatin and phytoestrogen and other sex hormones like substances present in coconut water and a young coconut juice (YCJ) in reducing the chance of AD. Coconut is known as a 'functional food' that is extremely nutritious. Virgin coconut oil (VCO) differs from ordinary coconut oil as the former contains a lot more biologically active components. Phenolic compounds and hormones contained in coconut can help prevent amyloid b peptide aggregation, potentially inhibiting a key step in the pathogenesis of AD. Coconut can be useful in the treatment of obesity, dyslipidemia, elevated low-density lipoproteins, insulin resistance, and hypertension-these are the risk factors for chronic venous disease and type II diabetes, as well as for AD.

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Can coconut oil and treadmill exercise during the critical period of brain development ameliorate stress-related effects on anxiety-like behavior and episodic-like memory in young rats?

Abstract: CO and exercise during lactation can ameliorate the effects of stress on anxiety-like behavior and episodic-like memory in young rats.

Cited by 11 publications

References 34 publications

Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice

Acute and chronic effects of oral administration of a medium‐chain fatty acid, capric acid, on locomotor activity and anxiety‐like and depression‐related behaviors in adult male C57BL/6J mice

Lauric acid promotes neuronal maturation mediated by astrocytes in primary cortical cultures

Effects of coconut oil on Alzheimer disease

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