Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study

Salarolli, Roberta; Alvarenga, Livia; Cardozo, Ludmila F M F; Teixeira, Karla Thaís Resende; Moreira, Laís de Souza Gouveia; Lima, Jordana Dinorá de; Rodrigues, Silvia; Nakao, Lia S.; Fouque, Denis; Mafra, Denise

doi:10.1007/s11255-020-02760-z

Cited by 35 publications

(25 citation statements)

References 60 publications

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“…In a recent study by Salarolli et al, the oral supplementation of curcumin (2.5 g of turmeric for three months) seemed to reduce PCS plasma levels in hemodialysis patients [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease

et al. 2022

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Chronic kidney disease (CKD) subjects suffer from high risk of cardiovascular mortality, and any intervention preventing the progression of CKD may have an enormous impact on public health. In the last decade, there has been growing awareness that the gut microbiota (GM) can play a pivotal role in controlling the pathogenesis of systemic inflammatory state and CKD progression. To ameliorate the quality of life in CKD subjects, the use of dietary supplements has increased over time. Among those, curcumin has demonstrated significant in vitro anti-inflammatory properties. In this pilot study, 24 CKD patients and 20 healthy volunteers were recruited. CKD patients followed nutritional counselling and were supplemented with curcumin (Meriva®) for six months. Different parameters were evaluated at baseline and after 3–6 months: uremic toxins, metagenomic of GM, and nutritional, inflammatory, and oxidative status. Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation. Regarding GM, after 6 months of curcumin supplementation, Escherichia-Shigella was significantly lower, while Lachnoclostridium was significant higher. Notably, at family level, Lactobacillaceae spp. were found significantly higher in the last 3 months of supplementation. No adverse events were observed in the supplemented group, confirming the good safety profile of curcumin phytosome after long-term administration.

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“…In a recent study by Salarolli et al, the oral supplementation of curcumin (2.5 g of turmeric for three months) seemed to reduce PCS plasma levels in hemodialysis patients [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease

et al. 2022

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“…Previous evidence has demonstrated that the composition, modification and disturbance of gut microbiota affect important physiological processes, including energy metabolism and microenvironmental homeostasis. 10 , 11 The gut dysbiosis held great significance in susceptibility to and development of various diseases in vivo in rodent and human studies, including obesity, type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD) 12 , 13 and rheumatoid arthritis (RA). 14 Subsequent studies reported that gut microbiota could lead to chronic inflammation and imbalance of immune system referring to small-molecule constituents such as short-chain fatty acids (SCFA) and secondary bile acids and trim-ethylamine.…”

Section: Introductionmentioning

confidence: 99%

Recent Insights into the Role of Gut Microbiota in Diabetic Retinopathy

Jiao¹,

Yu²,

Yao³

et al. 2021

JIR

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The microbiome has become a hot issue in recent years. The composition, modification, alteration, and disturbance of gut microbiota were found to influence important physiological processes, including energy metabolism and microenvironmental homeostasis, and lead to various diseases, including obesity, type 2 diabetes mellitus and chronic kidney disease. Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and one of the leading causes of blindness and vision impairment. The underlying mechanisms in DR pathogenesis remain limited. Recently, important insights have been made regarding possible connections between gut microbiome dysbiosis and ocular disease including DR, uveitis, glaucoma, and age-related macular degeneration, and the concept of a “microbiota–gut–retina axis” has been put forward. Hence, we reviewed current understanding of the relationship between DR and gut microbiota. We summarized potential pathophysiological mechanisms that contribute to the role of the gut microbiota on DR, including hyperglycemia, anti-diabetes drugs, microbial metabolites, and inflammatory properties. We aimed to find novel effective therapeutic options to prevent the onset and development of DR.

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“…One possible strategy to control disease outcomes is to alter the gut microbial profile through the use of dietary supplements, among which curcumin has been most studied [ 75 ]. Curcumin (CUR) is a natural polyphenolic compound and the active ingredient in the Indian dietary spice turmeric ( Curcuma longa ), which also holds the curcuminoids demethoxicurcumin and bisdemetoxicurcumin [ 77 ]. Curcumin has long been studied for its anti-inflammatory, anti-oxidative, anti-microbial, and anti-proliferative potential, and its supplementation has been proven to significantly alter the gut microbiota composition [ 75 ].…”

Section: Novel Therapeutic Approaches In Management Of Urological Dis...mentioning

confidence: 99%

“…Through its ability to increase the expression of intestinal alkaline phosphatase, decrease intestinal permeability, and decrease the production of inflammatory cytokines, curcumin can potentially change the gut’s microbial communities [ 78 ]. Several studies and clinical trials (NCT04413266) are on the rise to classify curcumin as a promising adjunct in the treatment of CKD and its complications [ 75 , 77 ]. Pivari et al, through gut microbiota genome sequencing and analysis, found a significant shift to Lachnospiraceae, Prevotellaceae, and Ruminococcaceae family abundance in CKD patients supplemented with curcumin for six months, concluding that the latter’s gut composition shifted towards that of the healthy controls [ 75 ].…”

Section: Novel Therapeutic Approaches In Management Of Urological Dis...mentioning

confidence: 99%

The Urogenital System’s Role in Diseases: A Synopsis

Zerdan

Moukarzel

Naji

et al. 2022

Cancers

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The human microbiota contains ten times more microbial cells than human cells contained by the human body, constituting a larger genetic material than the human genome itself. Emerging studies have shown that these microorganisms represent a critical determinant in human health and disease, and the use of probiotic products as potential therapeutic interventions to modulate homeostasis and treat disease is being explored. The gut is a niche for the largest proportion of the human microbiota with myriad studies suggesting a strong link between the gut microbiota composition and disease development throughout the body. More specifically, there is mounting evidence on the relevance of gut microbiota dysbiosis in the development of urinary tract disease including urinary tract infections (UTIs), chronic kidney disease, and kidney stones. Fewer emerging reports, however, are suggesting that the urinary tract, which has long been considered ‘sterile’, also houses its unique microbiota that might have an important role in urologic health and disease. The implications of this new paradigm could potentially change the therapeutic perspective in urological disease.

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Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study

Cited by 35 publications

References 60 publications

Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease

Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease

Recent Insights into the Role of Gut Microbiota in Diabetic Retinopathy

The Urogenital System’s Role in Diseases: A Synopsis

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