Can diffusion tensor imaging and tractography represent cross‐sectional area of lumbar multifidus in patients with LUMBAR spine disease?

Oh, Jeehae; Jung, Joon-Yong; Ko, Young Jin

doi:10.1002/mus.25639

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…DTT is a recently developed three-dimensional reconstruction technique of DTI. It shows fiber bundles with connectedness of voxels having similar diffusion properties (Oh et al, 2018). It is commonly applied in neurosurgical settings to avoid damage to surrounding vital neural pathways and to guide deep brain stimulation electrodes toward their targets (Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review

2021

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Diffusion tensor tractography (DTT) is derived from diffusion tensor imaging. It has allowed visualization and estimation of neural tract injury, which may be associated with the pathogenesis of neuropathic pain (NP). The aim of the present study was to review DTT studies that demonstrated the relationship between neural injuries and NP and to describe the potential use of DTT in the evaluation of neural injuries that are involved in the pathophysiological process of NP. A PubMed search was conducted for articles published until July 3, 2020, which used DTT to investigate the association between neural injuries and NP. The key search phrase for identifying potentially relevant articles was (diffusion tensor tractography AND pain). The following inclusion criteria were applied for article selection: (1) studies involving patients with NP and (2) studies in which DTT was applied for the evaluation of NP. Review articles were excluded. Altogether, 108 potentially relevant articles were identified. After reading the titles and abstracts and assessment of eligibility based on the full-text articles, 46 publications were finally included in our review. The results of the included studies suggested that DTT may be beneficial in identifying the pathophysiological mechanism of NP of various origins including central pain caused by brain injuries, trigeminal neuralgia, sciatica, and some types of headache. Further studies are needed to validate the efficacy of DTT in investigating the pathophysiology of other types of NP.

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Section: Introductionmentioning

confidence: 99%

The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review

2021

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Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure

et al. 2020

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Magnetic resonance imaging (MRI) is a diagnostic tool that can be used to noninvasively assess lumbar muscle size and fatty infiltration, important biomarkers of muscle health. Diffusion tensor imaging (DTI) is an MRI technique that is sensitive to muscle microstructural features such as fiber size (an important biomarker of muscle health), which is typically only assessed using invasive biopsy techniques. The goal of this study was to establish normative values of level‐dependent lumbar muscle size, fat signal fraction, and restricted diffusion assessed by MRI in a highly active population. Forty‐two active‐duty Marines were imaged using a (a) high‐resolution anatomical, (b) fat‐water separation, and (c) DT‐MRI scan. The multifidus and erector spinae muscles were compared at each level using two‐way repeated measures ANOVA. Secondary analysis included Three dimensional (3D) reconstructions to qualitatively assess lumbar muscle size, fatty infiltration, and fiber orientation via tractography. The erector spinae was found to be larger than the multifidus above L5, with lower fat signal fraction above L3, and a less restricted diffusion profile than the multifidus above L4, with this pattern reversed in the lower lumbar spine. 3D reconstructions demonstrated accumulations of epimuscular fat in the anterior and posterior regions of the lumbar musculature, with minimal intramuscular fatty infiltration. Tractography images demonstrated different orientations of adjacent lumbar musculature, which cannot be visualized with standard MRI pulse sequences. The level dependent differences found in this study provide a normative baseline, for which to better understand whole muscle and microstructural changes associated with aging, low back pain, and pathology.

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Changes in lumbar muscle diffusion tensor indices with age

Weedall,

Dallaway,

Hattersley

et al. 2023

BJR|Open

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Objective To investigate differences in diffusion tensor imaging (DTI) parameters and proton density fat fraction (PDFF) in the spinal muscles of younger and older adult males, Methods Twelve younger (19-30years) and 12 older (61-81years) healthy, physically active male participants underwent T1W, T2W, Dixon and Diffusion Tensor imaging of the lumbar spine. The eigenvalues (λ1, λ2, λ3) fractional anisotropy (FA) and mean diffusivity (MD) from the DTI together with the PDFF were determined in the multifidus (MF), medial and lateral erector spinae (ESmed, ESlat) and quadratus lumborum (QL) muscles. A two-way ANOVA was used to investigate differences with age and muscle and t-tests for differences in individual muscles with age. Results The ANOVA gave significant differences with age for all DTI parameters and the PDFF (p < 0.01) and with muscle (p < 0.01) for all DTI parameters except for λ1 and for the PDFF. The mean of the eigenvalues and MD were lower and the FA higher in the older age group with differences reaching statistical significance for all DTI measures for ESlat and QL (p < 0.01) but only in ESmed for λ3 and MD (p < 0.05). Conclusions Differences in DTI parameters of muscle with age result from changes in both in the intra- and extra-cellular space and cannot be uniquely explained in terms of fibre length and diameter. Advances in Knowledge Previous studies looking at age have used small groups with uneven age spacing. Our study uses two well defined and separated age groups.

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Can diffusion tensor imaging and tractography represent cross‐sectional area of lumbar multifidus in patients with LUMBAR spine disease?

Abstract: DTT can be a valuable tool to visualize and quantify the lumbar multifidus in lumbar spine disease. Muscle Nerve 57: 200-205, 2018.

Cited by 5 publications

References 26 publications

The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review

The Usefulness of Diffusion Tensor Tractography in Diagnosing Neuropathic Pain: A Narrative Review

Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure

Changes in lumbar muscle diffusion tensor indices with age

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