Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study

Grudzińska, Marta; Galanty, Agnieszka; Paśko, Paweł

doi:10.1016/j.tifs.2023.104130

Cited by 7 publications

(2 citation statements)

References 114 publications

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“…An increasing trend in the daily consumption and variety of different types of sprouts available in grocery stores is accompanied by a growing number of publications on the biological properties, such as antioxidant, anti-inflammatory, and cytotoxic effects, of these new elements of the human diet. Sprouts, being a part of the plant with unique concentrations of active compounds, may have significant chemopreventive potential, as confirmed in the recent systematic review published by our research group [1].…”

Section: Introductionsupporting

confidence: 61%

Can Simulated Microgravity and Darkness Conditions Influence the Phytochemical Content and Bioactivity of the Sprouts?—A Preliminary Study on Selected Fabaceae Species

Grudzińska,

Galanty,

Prochownik

et al. 2024

Plants

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Sprouts’ consumption has become popular due to their wide availability, easy cultivation process, and proven biological activity. Moreover, stress factors, such as limited access to light or disturbed gravity during growth, may contribute to the increased activity and the synthesis of bioactive compounds. In this study, for the first time, the examination of the impact of darkness and simulated microgravity conditions on the white clover sprouts from the Fabaceae family was conducted. Among several species, used in the preliminary attempts, only white clover was satisfactory sprouting in the disturbed gravity conditions, and thus was chosen for further examination. A random positioning machine setup was used during the cultivation process to simulate microgravity conditions. Additionally, the sprouts were cultivated in total darkness. Simulated microgravity and/or darkness during the first few days of the sprouts’ growth caused biomass reduction, the increased synthesis of bioactive compounds (isoflavones and phenolics), and changes in the level of abscisic acid and phenylalanine ammonia-lyase. Moreover, it increased the antioxidant properties of the sprouts, while the enhancement of their cytotoxic impact was observed only for androgen-dependent prostate cancer LNCaP cells. To conclude, the presented results are promising in searching for novel functional food candidates and further studies are necessary, directed at other plant families.

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Section: Introductionsupporting

confidence: 61%

Can Simulated Microgravity and Darkness Conditions Influence the Phytochemical Content and Bioactivity of the Sprouts?—A Preliminary Study on Selected Fabaceae Species

Grudzińska,

Galanty,

Prochownik

et al. 2024

Plants

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“…It is known that sprouts can be a significant element in the chemoprevention of hormone-dependent cancers, including prostate [ 9 ]. Chickpea sprouts are an example of functional foods rich in isoflavones [ 10 ], with a structure reminiscent of 17β-estradiol.…”

Section: Introductionmentioning

confidence: 99%

Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders—A Preliminary In Vitro Study

Galanty,

Prochownik,

Grudzińska

et al. 2024

Molecules

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Background: Prostate cancer (PC) and benign prostatic hyperplasia (BPH) are common health problems in the aging male population. Due to the unexplored and unconfirmed impact of food containing isoflavones, like sprouts, on the development of the management of BPH and prostate cancer, we decided to extend the knowledge in this area. Results: We have demonstrated for the first time that chickpea sprouts may play an important role in the chemoprevention of prostate disorders. However, attention should be paid to the isoflavone content in the sprouts, as in our study, chickpea sprouts with a moderate concentration of the compounds, harvested in natural light conditions (CA10L) and blue LED light (CA7B), showed the best scores in terms of their potential towards prostate disorders. Methods: Chickpea seeds were grown in LED chambers. The methanol extracts from sprouts were quantitatively defined using the HPLC system. Experiments such as the determination of PSA, 5-α-reductase, and dihydrotestosterone were performed on PNT2 and LNCaP cells. For anti-inflammatory assays (determination of NO, IL-6, and TNF-alpha release), murine RAW264.7 macrophages were used. Conclusions: The role of legume products as a diet element should be deeply evaluated for the development of future dietary recommendations for prostate cancer and BPH prevention.

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Insights into light-driven dynamics of phytochemicals in sprouts and microgreens

Ali,

Mandal,

Vyas

2024

Plant Growth Regul

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Can edible sprouts be the element of effective chemopreventive strategy? - A systematic review of in vitro and in vivo study

Cited by 7 publications

References 114 publications

Can Simulated Microgravity and Darkness Conditions Influence the Phytochemical Content and Bioactivity of the Sprouts?—A Preliminary Study on Selected Fabaceae Species

Can Simulated Microgravity and Darkness Conditions Influence the Phytochemical Content and Bioactivity of the Sprouts?—A Preliminary Study on Selected Fabaceae Species

Chickpea Sprouts as a Potential Dietary Support in Different Prostate Disorders—A Preliminary In Vitro Study

Insights into light-driven dynamics of phytochemicals in sprouts and microgreens

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