2012
DOI: 10.1186/1471-2407-12-432
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Can exercise ameliorate treatment toxicity during the initial phase of testosterone deprivation in prostate cancer patients? Is this more effective than delayed rehabilitation?

Abstract: BackgroundThere has been substantial increase in use of androgen deprivation therapy as adjuvant management of prostate cancer. However, this leads to a range of musculoskeletal toxicities including reduced bone mass and increased skeletal fractures compounded with rapid metabolic alterations, including increased body fat, reduced lean mass, insulin resistance and negative lipoprotein profile, increased incidence of cardiovascular and metabolic morbidity, greater distress and reduced quality of life. Numerous … Show more

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Cited by 21 publications
(25 citation statements)
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“…Lifestyle factors should be optimised by smoking cessation and limitation of alcohol consumption. Regular exercise is recommended and ongoing trials of resistance, aerobic and impact-loading exercises should better define the role of exercise in the maintenance of skeletal health (Newton et al 2012). There is no consensus regarding calcium and vitamin D supplementation.…”
Section: Addressing Bone Risk In Men Receiving Adtmentioning
confidence: 99%
“…Lifestyle factors should be optimised by smoking cessation and limitation of alcohol consumption. Regular exercise is recommended and ongoing trials of resistance, aerobic and impact-loading exercises should better define the role of exercise in the maintenance of skeletal health (Newton et al 2012). There is no consensus regarding calcium and vitamin D supplementation.…”
Section: Addressing Bone Risk In Men Receiving Adtmentioning
confidence: 99%
“…Notably, calcium and vitamin D supplementation likely play a beneficial role when considering exercise training that elicits bone-related adaptations, however, this section will focus on the potential benefits predominantly on muscle. To date, no studies have examined the combination of exercise training and nutritional supplementation in these men; however, one study is currently being conducted [288] .…”
Section: The Role Of Combined Exercise Training and Nutritional Supplmentioning
confidence: 99%
“…The study is examining the role of a six month exercise training program combined with nutritional supplementation (1,000 mg calcium and 800 IU vitamin D per day) on various aspects of health influenced by ADT [288] . No results have been published from this trial.…”
Section: The Role Of Combined Exercise Training and Nutritional Supplmentioning
confidence: 99%
“…Although these are preliminary studies, they suggest that exercise may provide some benefit in lessening the adverse metabolic effects of ADT. Two randomized trials are presently being conducted to investigate this further 74,75…”
Section: Impact Of Exercise On Patients With Prostate Cancermentioning
confidence: 99%
“…Vitamin D, but not calcium, was shown to provide some protection from bone density loss, especially in the first year of ADT. It seems likely that the efficacy of vitamin D and calcium supplementation may require implementation of concomitant exercise programs to stimulate bone accrual, as discussed earlier 36,38,75…”
Section: Effect Of Nutrition and Dietary Supplements On The Complicatmentioning
confidence: 99%