Can fecal calprotectin serve as a screen for necrotizing enterocolitis in infants?

Goold, Eric; Pearson, Linda; Johnson, Lisa M.

doi:10.1016/j.clinbiochem.2020.06.015

Cited by 4 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with previous observations, where elevated levels and drastic changes of FC dynamics were reported among very preterm infants during early life ( 7 , 31 – 34 ). The age-dependent patterned progression of FC dynamics highlights the significant impact of postnatal age, particularly during the first month of life, which accounts for the high variations of FC levels.…”

Section: Discussionsupporting

confidence: 94%

“…Over recent decades, fecal calprotectin (FC) has emerged as a reliable biomarker for assessing gastrointestinal (GI) inflammation in adults and older children ( 2 ). However, during the neonatal period, physiological FC dynamics are complex and poorly understood, characterized by elevated levels with substantial interindividual and intraindividual variability ( 3 – 6 ), which poses challenges for clinical application ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Postnatal Dynamics and Clinical Associations of Fecal Calprotectin in Very Preterm Infants: Implications for Necrotizing Enterocolitis and Feeding Intolerance

Hong

Huang

Jiang

et al. 2023

Clin Transl Gastroenterol

View full text Add to dashboard Cite

INTRODUCTION: To elucidate the postnatal dynamics and clinical associations of fecal calprotectin (FC) in very preterm infants, with a focus on necrotizing enterocolitis (NEC) and feeding intolerance (FI). METHODS: We performed a prospective observational cohort study in infants with a gestational age of <32 weeks or birth weight <1,500 g with weekly feces collection. The relationships between FC, NEC, and FI were investigated, adjusting for demographic and clinical factors. RESULTS: A total of 1,086 fecal samples were collected from 194 preterm infants. Postnatal FC levels of non-NEC infants were highly variable and followed an age-dependent patterned progression. FC levels were elevated in patients with NEC before and at NEC onset, distinguishing them from non-NEC infants and those at sepsis onset. Among infants without NEC or sepsis, those with FI exhibited lower FC concentrations throughout hospitalization and displayed a significant delay in reaching high FC levels after meconium compared with non-FI infants. The age to reach the first high nonmeconial FC levels was positively associated with the time to achieve full enteral feeding. DISCUSSION: Postnatal FC dynamics among premature infants followed a patterned progression but were disturbed in patients with NEC and FI. Because of the high variations, the use of FC levels in NEC diagnosis should be implemented with caution in clinical practice. FC may help understand FI and feeding progression in very preterm infants. Further research is needed to validate these findings and explore the potential clinical applications of FC in this population.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Postnatal Dynamics and Clinical Associations of Fecal Calprotectin in Very Preterm Infants: Implications for Necrotizing Enterocolitis and Feeding Intolerance

Hong

Huang

Jiang

et al. 2023

Clin Transl Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Измерение уровня Cp широко используется при диагностике воспалительных заболеваний ЖКТ в педиатрической практике и у взрослых пациентов, однако результаты исследований Ср у новорожденных детей крайне малочисленны и противоречивы [12,13]. Отсутствуют референсные значения для новорожденных различного гестационного и постконцептуального возраста [13]. Значения данного маркера широко варьируют в зависимости от ГВ и постнатального возраста [14].…”

Section: Introductionunclassified

Fecal Calprotectin Levels Dynamics in Newborns with High-Risk of Necrotizing Enterocolitis

et al. 2023

View full text Add to dashboard Cite

Background. Necrotizing enterocolitis (NEC) is severe gastrointestinal disease in newborns, its early clinical symptoms are nonspecific. Fecal сalprotectin (Cp) is considered as one of the early biomarkers of NEC, thus, its use in newborns is poorly known.Objective. The aim of the study is to evaluate clinical significance of fecal Cp measuring as an early NEC marker in newborns. Methods. The prospective cohort observational study included high-risk newborns (gestational age (GA) ˂ 33 weeks and/or body weight ˂ 1500 g) and moderate risk newborns (GV≥ 33 weeks at suspicion on NEC) of NEC admitted to the neonatal intensive care unit on the 1st day of life. The Cp level was studied via immune colorimetric method on the 3rd and 7th days of life in high-risk children and in all children at NEC manifestation. All patients were divided into 2 main subgroups after the end of the follow-up period: newborns with developed NEC (a) and children without NEC (b). Obtained Cp values were compared between these subgroups.Results. There were no statistically significant differences in Cp levels at the 3rd and 7th days of life in the high-risk group of children with NEC and without NEC. However, it was noted that children without NEC showed a decrease in Cp levels on the 7th day, while children with NEC manifestation, indeed, had increased levels. Cp levels did not differ in the moderate risk group.Conclusion. Single measurement of Cp level in newborns of any GA is uninformative towards the NEC prognosis and diagnosis. However, evaluation of the Cp level dynamics at the 7th day of life compared to the 3rd day of life may be considered as a promising non-invasive method for prognosis of NEC manifestation in premature infants (GA<33 weeks).

show abstract

Advances in Non-Invasive Biomarkers for Early Diagnosis of NEC

王

2024

ACM

View full text Add to dashboard Cite

Can fecal calprotectin serve as a screen for necrotizing enterocolitis in infants?

Cited by 4 publications

References 29 publications

Postnatal Dynamics and Clinical Associations of Fecal Calprotectin in Very Preterm Infants: Implications for Necrotizing Enterocolitis and Feeding Intolerance

Postnatal Dynamics and Clinical Associations of Fecal Calprotectin in Very Preterm Infants: Implications for Necrotizing Enterocolitis and Feeding Intolerance

Fecal Calprotectin Levels Dynamics in Newborns with High-Risk of Necrotizing Enterocolitis

Advances in Non-Invasive Biomarkers for Early Diagnosis of NEC

Contact Info

Product

Resources

About