Can Functional Polymorphisms in &lt;b&gt;&lt;i&gt;VEGF&lt;/i&gt;&lt;/b&gt; and &lt;b&gt;&lt;i&gt;MMP&lt;/i&gt;&lt;/b&gt; Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Prasun, Pankaj; Madan, Raghav; Puthuraya, Subhash; Subramanian, Divya; Datta, Ishita; Kalra, Vaneet Kumar; Thomas, Ronald; Stockton, David W.; Sundaram, Senthilarasu; Callaghan, Joseph H.; Callaghan, Michael U.; Chouthai, Nitin

doi:10.1159/000493788

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Similarly, there was approximately a 3.5-fold increased risk of developing IVH in preterm infants with the GT eNOS 894G > T polymorphism of endothelial nitric oxide synthase (eNOS), a gene associated with blood flow [12]. Prasun P et al examined polymorphisms in VEGF and showed a higher prevalence of IVH in infants with GA/AA and AA/AC genotypes in VEGF RS1570360 and VEGF RS699947, respectively [36]. The fibronectin (FN1) gene has been assessed in relation to multiple disorders.…”

Section: Discussionmentioning

confidence: 99%

Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants

et al. 2020

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Background/introduction Intraventricular hemorrhage (IVH) is a dangerous complication facing a significant proportion of preterm infants. It is multifactorial in nature, and an observed fibronectin deficiency in the germinal matrix basal lamina is among the most prominent factors that influence such rupture. Better understanding of the FN1 gene polymorphisms and their role in IVH may further clarify the presence of a genetic susceptibility of certain babies to this complication. The aim of this study was to assess if 5 single nucleotide polymorphisms of the fibronectin gene may be linked to an increased incidence of IVH. Material and methods The study included 108 infants born between 24 and 32 weeks of gestation. IVH was diagnosed using cranial ultrasound performed on the 1st,3rd, and 7th day after birth and classified according to Papile et al. IVH classification. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655. Results IVH developed in 51 (47.2%) out of the 108 preterm infants. This includes, 18 (35.3%) with stage I IVH, 19 (37.3%) with stage II, 11 (21.6%) with stage III, and 3 (5.9%) with stage IV IVH. Incidence of IVH was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Analysis showed that IVH stage II to IV was approximately seven times more likely to occur in infants with the genotype TT FN1 rs10202709 (OR 7237 (1046-79.59; p = 0,044)). No other significant association was found with the rest of the polymorphisms. Conclusion The results of our study indicate a sevenfold increased genetic susceptibility to IVH in preterm infants with the TT FN1 rs10202709 gene polymorphism. The fibronectin gene polymorphism may therefore be of crucial importance as a genetic risk factor for IVH in preterm infants. Further studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants

et al. 2020

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“…A prospective study on 382 infants with a gestational age less than 28 weeks hospitalized in the neonatal intensive care unit analyzed 4 SNPs for VEGF polymorphisms (RS699947, RS2010963, RS3025039, and RS1570360). They established that the GA/AA genotype in VEGF RS1570360 and the AA/AC genotype in VEGF RS699947 were associated with elevated incidence rates of IVH in newborns ≤28 weeks of gestation ( p = 0.017) [ 119 ]. Additionally, a higher presence of the CC genotype for SNP VEGF RS3025039 tended to an increased incidence of IVH of principally African American newborns, and the CC genotype of VEGF RS1570360 was associated with a need for ventriculoperitoneal shunt placement surgery.…”

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

et al. 2023

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(1) Background: Vascular endothelial growth factor (VEGF) is essential in vasculo- and angiogenesis due to its role in endothelial cell proliferation and migration. As a vascular proliferative factor, VEGF is one of the hallmarks of cancer and, in adult populations, the relationship between genetic polymorphism and neoplasm was widely investigated. For the neonatal population, only a few studies attempted to uncover the link between the genetic polymorphism of VEGF and neonatal pathology, especially related to late-onset complications. Our objective is to evaluate the literature surrounding VEGF genetic polymorphisms and the morbidity of the neonatal period. (2) Methods: A systematic search was initially conducted in December 2022. The PubMed platform was used to explore MEDLINE (1946 to 2022) and PubMed Central (2000 to 2022) by applying the search string ((VEGF polymorphism*) and newborn*). (3) Results: The PubMed search yielded 62 documents. A narrative synthesis of the findings was undertaken considering our predetermined subheadings (infants with low birth weight or preterm birth, heart pathologies, lung diseases, eye conditions, cerebral pathologies, and digestive pathologies). (4) Conclusion: The VEGF polymorphisms seem to be associated with neonatal pathology. The involvement of VEGF and VEGF polymorphism has been demonstrated for retinopathy of prematurity.

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“…Such findings indicate that certain fibronectin polymorphisms can have a detrimental effect on the structural integrity of the germinal matrix. Furthermore, Prasun et al [ 24 ] found that the GG in VEGF RS1570360 and CC genotypes in VEGF RS699947 were risk factors for IVH in infants less than 28 weeks old. In another study, it was found that the genotype CC of MTHFR 1298A > C gene polymorphism increased the risk of IVH by approximately 4.5 times (OR: 4.51, p < 0.03) for infants less than 32 weeks of gestation.…”

Section: Discussionmentioning

confidence: 99%

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

et al. 2023

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Purpose The aim of this study was to evaluate the possible relationship between four single nucleotide polymorphisms of hemangioma-linked genes encoding for anthrax toxin receptor 1 (ANTXR1 G976A), R kinase insert domain receptor (KDR T1444C), adrenoceptor beta 2 (ADRB C79CG), and insulin-like growth factor 1 receptor (IGF-1R G3174A) and the occurrence of IVH in a population of preterm infants. Methods The study includes a population of 105 infants born from 24 + 0 to 32 + 0 weeks of gestation and hospitalized at the Department of Neonatology (III level hospital) of Poznan University of Medical Science. Intraventricular hemorrhage was diagnosed with the use of cranial ultrasound. The classification of intraventricular bleeding was based on the Papile IVH classification. Results The incidence of IVH was higher in infants with lower birth weight, lower APGAR scores, and low birth weight. The study revealed that IVH was approximately two times less likely to occur in infants with the allele G of IGF-1R 3174G > A. Conclusion Identifying susceptible premature infants through genetic analysis could be a potential way to alleviate severe IVH and its subsequent consequences. Further research examining a wider range of relevant gene polymorphisms could help highlight any genetic patterns in this deleterious bleeding complication.

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Can Functional Polymorphisms in <b><i>VEGF</i></b> and <b><i>MMP</i></b> Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Cited by 6 publications

References 34 publications

Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants

Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants

Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature

Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants

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