Direct tests of T, CP, CPT symmetries in transitions processes of neutral kaons are briefly reviewed. The exchange of in and out states required for a genuine test involving time-reversal is implemented exploiting the entanglement of
K
0
K
¯
0
pairs produced at a ϕ-factory.
A data sample collected by the KLOE experiment at DAΦNE corresponding to an integrated luminosity of about 1.7 fb−1 is analysed to study the ϕ → KSKL → π
+
π
−
πeν and ϕ → KSKL → πeν 3π
0 processes, and to perform the first direct tests of T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method.