Can .GAMMA.-Glutamyltransferase be an Additional Marker of Arterial Stiffness?

Song, Sang Heon; Kwak, Ihm Soo; Kim, Yun Jin; Kim, Seong-Jang; Lee, Soo Bong; Lee, Jun Young; Lee, Bong Eun

doi:10.1253/circj.71.1715

Cited by 23 publications

(21 citation statements)

References 20 publications

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“…However, a fairly different situation was observed when considering, de per se, subjects with deficient GSH levels ( Table 3), suggesting that obesity is much more associated with a decrease in GSH levels than with changes in the other thiols concentrations. Furthermore, the prevalence of both overweight and obesity in this study group did not seem to be particularly linked to GGT activity, since no differences were observed between n-and hGGT groups (Table 4), which is not in agreement with other reports [37].…”

Section: Plasma Aminothiol Profile and Bmicontrasting

confidence: 83%

Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean Subjects

Lima

Ferin

Baptista

et al. 2014

ISRN Oxidative Medicine

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Objectives. To evaluate the plasma aminothiol profile (PAP) and serum gamma-glutamyltransferase (GGT) activity, as well as plasma folate, vitamin B 12 , and vitamin B 6 concentrations, in 326 apparently healthy subjects from the Azores archipelago (Portugal). Also eventual relationships of PAP with conventional risk factors for atherosclerosis were investigated, aiming at the finding of early blood markers of the disease. Design and Methods. This was an observational cross-sectional study, where participants were split into two groups: one with a normal and another with an altered PAP (at least one aminothiol out of its reference concentration range). Results. About 76% of subjects had an altered PAP, mainly due to low glutathione levels (<1.5 mol/L), mostly associated with normal GGT activity. Prevalence of hyperhomocysteinemia was 10%, where only 33% had some B-vitamin deficiency. The risk for atherosclerosis was more evidenced in subjects exhibiting both deficient GSH concentration and increased serum GGT activity.Conclusions. An altered PAP, namely, when caused by low GSH levels in the absence of alterations in the Hcy, or Cys, or Cys-Gly concentrations and in serum GGT activity, might reveal a subclinical stage of atherogenesis and should be explored as a potential early marker of atherosclerosis.

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Section: Plasma Aminothiol Profile and Bmicontrasting

confidence: 83%

Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean Subjects

Lima

Ferin

Baptista

et al. 2014

ISRN Oxidative Medicine

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“…Furthermore, in one screened cohort, increased PWV was associated with low creatinine clearance, age, systolic blood pressure, proteinuria, fasting glucose, and cholesterol (12). However, in the previous study, serum creatinine and creatinine-based GFR were not independent contributors to increased baPWV (24). In the present study, serum cystatin C had a significant relationship with baPWV independent of other suggested contributors, but serum creatinine and creatinine-based GFR were not the independent variables in multivariate regression analysis.…”

Section: Discussionmentioning

confidence: 65%

Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

et al. 2008

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We hypothesized that serum cystatin C can be a more predictable marker of arterial stiffness than serum creatinine and creatinine-based glomerular filtration rate (GFR). The aim of this study is to evaluate whether serum cystatin C is related to arterial stiffness independently of serum creatinine in subjects for whom serum creatinine is normal. A total of 2,018 individuals (1,120 males, 898 females) were enrolled. Mean brachial-ankle pulse wave velocity (baPWV) was used as a marker of arterial stiffness and sex-specific analysis

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“…1,32,33 In fact, a relationship between GGT and arterial stiffness as a potential marker of endothelial dysfunction was recently suggested. 34 Moreover, C-reactive protein and uric acid, which are considered indicators of inflammation and oxidative stress, respectively, have been associated with the development and progression of heart failure. 35,36 The fact that in our cohort of patients GGT levels were associated with both C-reactive protein and uric acid may support the potential association between GGT and inflammation and oxidative stress in patients with heart failure.…”

Section: Poelzl Et Almentioning

confidence: 99%

Prevalence and Prognostic Significance of Elevated γ-Glutamyltransferase in Chronic Heart Failure

Poelzl

Eberl

Achrainer

et al. 2009

Circ: Heart Failure

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Background-Serum ␥-glutamyltransferase (GGT) is associated with incident cardiovascular diseases and is a potential risk factor for disease mortality. We investigated the relevance of circulating GGT in chronic heart failure. Methods and Results-From 2000 to 2007 clinical and laboratory variables of 1033 consecutive outdoor patients with heart failure were evaluated. Follow-up (mean, 34.4 months) was available in 998 patients. The end point was defined as death from any cause or heart transplantation. A forward stepwise Cox proportional hazards regression model for sex-stratified data was used. Prevalence of elevated GGT was 42.9% in men (GGT Ͼ65 U/L) and 50.2% in women (GGT Ͼ38 U/L), which was higher than for sex-and age-matched healthy subjects (18.6% in men, 19.2% in women) derived from a large historical control group. GGT was associated with severity of heart failure as assessed by New York Heart Association class, left-ventricular ejection fraction, and amino-terminal pro-B-type natriuretic peptide. The end point was recorded in 302 patients. Compared with the lowest GGT quintile, sex-stratified hazard ratios for patients in the highest quintile were 2.88 (1.99 to 4.17) in the univariate model and 1.87 (1.28 to 2.74) in the adjusted model (PϽ0.001). Corresponding 5-year cumulative event rates were 47% and 74%, respectively. Adjusted hazard ratios for elevated GGT was 2.9 (1.64 to 5.17) for patients in New York Heart Association I/II, and 1.2 (0.75 to 2.05) for patients in New York Heart Association III/IV, respectively (Pϭ0.003, for the GGT-New York Heart Association class interaction). Conclusions-Prevalence of elevated GGT is high in patients with chronic heart failure. The GGT levels are associated with disease severity. Increased GGT is an independent predictor of death or heart transplantation. GGT may provide additional prognostic information, especially in patients with mild heart failure. (Circ Heart Fail. 2009;2:294-302.)

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Can .GAMMA.-Glutamyltransferase be an Additional Marker of Arterial Stiffness?

Cited by 23 publications

References 20 publications

Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean Subjects

Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean Subjects

Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

Prevalence and Prognostic Significance of Elevated γ-Glutamyltransferase in Chronic Heart Failure

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