Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?

Dillner, Joakim; Brown, Darron R.

doi:10.1017/s1462399404007653

Cited by 6 publications

(6 citation statements)

References 115 publications

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“…41 The fact that the amino acid substitutions in the L1 protein were clustered in the surface-exposed loops of HPV38b[FA125] are also suggestive of a possible immunological significance of the subtype heterogeneity. While it is well known that HPV variants within the same type constitute the same serotype 42 and that different HPV types typically constitute different serotypes, 43 it is not well known whether subtypes are usually serologically distinct or not. 39 Even when combining the prevalences of HPV38 and HPV38b [FA125], we found considerably lower prevalences of these viruses in skin lesions than many other studies that did not use stripping of the skin surface.…”

Section: Discussionmentioning

confidence: 99%

Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38

Hazard

Eliasson

Dillner

et al. 2006

Intl Journal of Cancer

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The human papillomaviruses (HPVs) exist as more than 100 distinct types. While variants of HPV are common, only few HPV subtypes have been reported. HPV type 38 has been proposed to be associated with nonmelanoma skin cancer (NMSC), with reported prevalences of up to 55%. A subtype of HPV38 was cloned, completely sequenced and found to have a 96% sequence similarity to prototype HPV38 in the L1 open reading frame. The presence of prototype HPV38 and HPV38b[FA125] was examined in paired biopsies of tape-stripped skin lesions and healthy skin from 269 immunocompetent patients by real-time PCR. Prototype HPV38 and HPV38b[FA125] were present in seven (3%) and five (2%) lesions, respectively, in viral loads ranging from one copy per 150 cells to one copy per 70,000 cells. In summary, we found that HPV38 is heterogeneous and is one of so far only few HPVs that contain subtypes. The heterogeneity needs to be considered in studies of the biology of this virus. ' 2006 Wiley-Liss, Inc.Key words: HPV; subtype; nonmelanoma skin cancer; multiplyprimed rolling circle amplification Nonmelanoma skin cancers (NMSC) are the most prevalent malignancies in the Caucasian population 1 and an increase in prevalence has been seen in European countries during the last few years. 2 NMSC comprises basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC has a relatively good prognosis, while SCC accounts for up to 20% of all deaths from skin cancer. 3 NMSC are often found on sun-exposed sites in patients with the rare inherited genetic disease epidermodysplasia verruciformis (EV). 4 These patients are highly susceptible to human papillomavirus (HPV) infections 5,6 mainly by the Beta-papillomaviruses, a phylogenetic subgroup of cutaneous HPVs (e.g., HPV5 and HPV8). 7 These HPV types are detectable in skin carcinomas, as well as in control specimens of healthy skin from the general population. [8][9][10][11][12] There are more than 100 different HPV types that have been completely sequenced. 7 In addition, there appears to exist about 100 additional putative HPV types, with sequence information so far available only from PCR amplimers. 8,[13][14][15][16] Variants of HPV types contain more than 98% sequence homology in the L1 open reading frame (ORF). 7 Variants is a common finding that appears to associate with ethnic groups and sometimes even with biologic behavior of the virus. 17,18 By contrast, subtypes containing 90-98% sequence homology in the L1 region are very rare, with HPV 68a/HPV68b, HPV46, HPV55 and HPV64 (now known to be subtypes, originally thought to be different viruses) being the only fully characterized examples. 7,17 Although the reasons for this are not known, existence of subtypes has profound implications for design of virus detection systems and for understanding of the biology of the viruses.Epidemiological studies have established a causal association between UV-radiation and NMSC, 3 but the role of HPV in these cancers remains to be elucidated.A recent study 19 has demonstrated that the early proteins E...

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Section: Discussionmentioning

confidence: 99%

Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38

Hazard

Eliasson

Dillner

et al. 2006

Intl Journal of Cancer

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“…Important examples include cardiovascular diseases, allergies, and cancer. Exposure to infections accounts for ϳ17% of human cancers, with human papillomavirus (HPV) being one of the most important oncogenic infections (5 ). HPV infection causes almost all cervical cancers as well as a significant proportion of cancers of the vulva, vagina, penis, anus, and oropharynx; together these HPV-related cancers account for Ͼ5% of all human cancers (5 ).…”

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confidence: 99%

“…The antibody response to HPV is, in general, typespecific, and HPV serology is an important technology for determining the spread of type-specific HPV infections in populations and monitoring of the effect of HPV vaccines in inducing protective antibodies (5 ). Today, HPV serology is performed mostly in a limited number of expert laboratories, but it is likely to become widely used in clinical laboratories in the post-HPV vaccination era.…”

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Toward “Serolomics”: Papillomavirus Serology Is Taking a Technologic Lead in High-Throughput Multiplexed Antibody Analysis

Dillner

2005

Clinical Chemistry

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“…A significant causal association is found between CC and repeated human papillomavirus (HPV) infections over time (Dillner & Brown, 2004). HPV can be transmitted from an infected man to an uninfected woman through sexual contact (Denny, 2010).…”

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confidence: 99%

“…develops slowly and may be present for several years before symptoms start appearing (Dillner & Brown, 2004). Thus, even though women carry the burden of the disease, men play a role in transmission of the virus to female partners.…”

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The male role in cervical cancer prevention and transmission: Representation of subject positions in South African press reports (1998-2014)

Moodley

Vries

2016

PINS

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PINS, 2016, 52, 44 -70, http://dx.doi.org/10.17159/2309-8708/2016/n52a3 Developing countries have the highest rates of cervical cancer (CC), the most commonly occurring cancer among South African (SA) women (Denny, 2006). A significant causal association is found between CC and repeated human papillomavirus (HPV) infections over time (Dillner & Brown, 2004). HPV can be transmitted from an infected man to an uninfected woman through sexual contact (Denny, 2010). After transmission of oncogenic HPV, CC

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Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?

Abstract: Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine?Dillner, Joakim; Brown, Darron R

Cited by 6 publications

References 115 publications

Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38

Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38

Toward “Serolomics”: Papillomavirus Serology Is Taking a Technologic Lead in High-Throughput Multiplexed Antibody Analysis

The male role in cervical cancer prevention and transmission: Representation of subject positions in South African press reports (1998-2014)

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