Can Guduchi (Tinospora cordifolia), a well-known ayurvedic hepato-protectant cause liver damage?

selvam, Keerthi Panneer; Payyappallimana, Unnikrishnan; Ravikumar, Kaliamoorthy; Venkatasubramanian, Padma

doi:10.1016/j.jaim.2022.100658

Cited by 13 publications

(8 citation statements)

References 33 publications

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“…Hepatologists at the Jaslok Hospital and Research Centre, Mumbai, were the first to report 6 patients with Giloy herb consumption and acute hepatitis. [18] Giloy-induced autoimmune-like hepatitis or unmasked underlying silent autoimmune chronic liver disease due to its immune stimulant mechanism resulting in severe liver injury. Proponents of Ayurveda were quick to dismiss these cases as adulteration with another similar hepatotoxic herb, Tinospora crispa (L.) Hook.f.…”

Section: Tinospora Cordifolia (Willd) Hookf and Thomson (Giloy Guduchi)mentioning

confidence: 99%

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine

Philips,

Theruvath

2024

Medicine

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Complementary and alternative medicine-related liver injuries are increasing globally. Alternative medicine, as an inclusive healthcare practice, is widely accepted in developing and underdeveloped countries. In this context, the traditional systems of medicine in India have been at the forefront, catering to the preventive and therapeutic spectrum in the absence of conclusive evidence for benefits and lack of data on safety. Contrary to popular belief, it is evident that apart from adverse events caused by contamination and adulteration of alternative medicines, certain commonly used herbal components have inherent hepatotoxicity. This narrative review updates our current understanding and increasing publications on the liver toxicity potential of commonly used herbs in traditional Indian systems of medicine (Ayush), such as Tinospora cordifolia (Willd.) Hook.f. & Thomson (Giloy/Guduchi), Withania somnifera (L.) Dunal (Ashwagandha), Curcuma longa L. (Turmeric), and Psoralea corylifolia L. (Bakuchi/Babchi). This review also highlights the importance of the upcoming liver toxicity profiles associated with other traditional herbs used as dietary supplements, such as Centella asiatica (L.) Urb., Garcinia cambogia Desr., Cassia angustifolia Vahl (Indian senna), and Morinda citrofolia L. (Noni fruit). Fortunately, most reported liver injuries due to these herbs are self-limiting, but can lead to progressive liver dysfunction, leading to acute liver failure or acute chronic liver failure with a high mortality rate. This review also aims to provide adequate knowledge regarding herbalism in traditional practices, pertinent for medical doctors to diagnose, treat, and prevent avoidable liver disease burdens within communities, and improve public health and education.

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Section: Tinospora Cordifolia (Willd) Hookf and Thomson (Giloy Guduchi)mentioning

confidence: 99%

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine

Philips,

Theruvath

2024

Medicine

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“…T. cordifolia has traditionally been recommended for reducing hepatosplenomegaly, stimulating bile flow, and treating Kamala (jaundice) in cases of obstructive lesions. Over 33 % of the hepatoprotective formulas available in the Indian market contain this substance, and it can also be consumed independently as a standalone agent [ 124 ]. Instead of inducing hepatotoxicity, this plant is crucial for its hepatoprotective properties [ 125 ].…”

Section: Pharmacological Actionmentioning

confidence: 99%

“…In cases of carbon tetrachloride-induced liver injury, T. cordifolia has been seen to preserve normal metabolism and lower levels of particular enzymes such aspartate, alanine aminotransferase (ALT), alkaline phosphatase (ALP), aminotransferase (AST) and total bilirubin. The powerful hepatoprotective activities of T. cordifolia extract can be related to its ability to stimulate liver regeneration, as well as its antioxidant and free radical-scavenging properties [ 124 , 126 ] [ [124] , [126] , [127] , [128] ] [ [124] , [126] , [127] , [128] ]. A standardised aqueous extract was used to study patients with hepatic disorders who showed signs of immunosuppression and/or fibrosis.…”

Section: Pharmacological Actionmentioning

confidence: 99%

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

Chaudhary,

Das,

Mehta

et al. 2024

Heliyon

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“…and the recently described T. formanii Udayan and Pradeep. [3] Among these various species, Tinospora cordifolia and Tinospora crispa are widely distributed across India. Scientific reports indicate that T. crispa has been linked to adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…The leaves of T. cordifolia are heart-shaped with a groovy notch at the base, whereas T. crispa leaves are heart-shaped without a groovy notch at the base. [3,5] Therefore, accurately identifying the herb based on morphological characteristics is crucial when formulating herbal products to prevent any undesirable effects.…”

Section: Introductionmentioning

confidence: 99%

Formulation of Herbal Candies Containing Giloy Satva: A Nutritious and Palatable Herbal Confectionery Option

Deore,

Baviskar,

Kide

et al. 2023

Pharmacogn. Res.

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Background: Giloy (Tinospora cordifolia) is an Ayurvedic herb known for its numerous health benefits. Objectives: In this study, we aimed to prepare Giloy Satva candy. Materials and Methods: The candy was prepared by incorporating Giloy Satva in various concentrations batch wise, with other natural ingredients to enhance its palatability and therapeutic value. Physicochemical and therapeutic evaluation of the Giloy Satva candies involved assessing parameters such as moisture content, ash value, Total Soluble Solids (TSS), phytochemical screening, pH, sensory evaluation and Antioxidant assay. Results and Discussion: The finalized batch candy exhibited a desirable moisture content (7.44±0.08%), ash value (1.26±0.67%), and TSS (69.05 °Brix). The pH of the candy was found to be within the acceptable range (4.8±0.30), ensuring its stability and suitability for consumption. In sensory evaluation, the candy received positive feedback for its taste, texture, aroma, and overall acceptability. Furthermore, the antioxidant activity of the Giloy Satva candy was determined using in vitro DPPH assays. The candy exhibited significant antioxidant activity (53.23±0.23 μg/mL), indicating its potential to combat oxidative stress and associated health issues. Conclusion: In conclusion, the Giloy Satva candy demonstrated promising physicochemical properties, excellent sensory attributes, and potent antioxidant activity. The developed candy formulation could serve as a convenient and palatable herbal preparation, offering the benefits of Giloy in an easily consumable form. Further investigations, including stability studies and clinical trials, are warranted to explore its therapeutic potential and commercial viability.

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Can Guduchi (Tinospora cordifolia), a well-known ayurvedic hepato-protectant cause liver damage?

Cited by 13 publications

References 33 publications

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

Formulation of Herbal Candies Containing Giloy Satva: A Nutritious and Palatable Herbal Confectionery Option

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