Can gut microbiota of men who have sex with men influence HIV transmission?

Coleman, Sara L.; Neff, C. Preston; Li, Sam X.; Armstrong, Abigail J. S.; Schneider, Jennifer M.; Sen, Sharon; Fennimore, Blair; Campbell, Thomas; Lozupone, Catherine; Palmer, Brent E.

doi:10.1080/19490976.2019.1700756

Cited by 25 publications

(18 citation statements)

References 56 publications

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“…In a prior study we had established that rectal biopsy samples from HIV-positive and negative MSM exhibited higher levels of CCR5 + CD4 + T cells compared to those from non-MSM. 15 To establish whether the gut microbiome is a driver of these differences, we performed in vitro stimulations of LPMCs with FBCs and compared levels of CCR5 + CD4 + T cells across groups. To generate FBCs, whole intact bacteria were isolated from fecal slurries by density gradient centrifugation as described by our group previously.…”

Section: Resultsmentioning

confidence: 99%

“… 1 ,2 We had also previously shown that HIV-positive and high-risk MSM had elevated frequencies of the HIV co-receptor CCR5 + on CD4 + T cells in human gut biopsies. 15 Since MSM-associated factors such as trauma, douche, PrEP and antibiotics can also enhance HIV infection and CCR5 expression on CD4 + T cells in MSM, here we performed in vitro experiments specifically designed to examine the effect of the microbiome alone.…”

Section: Discussionmentioning

confidence: 99%

“… 14 We have previously shown that MSM have a greater number of CD4 + T cells expressing CCR5 in rectal biopsy samples compared with MSW, which may be a risk factor for HIV transmission in MSM. 15 However, it is not clear whether differences in microbiome composition drive elevated levels of these cells and if so, which particular microbes, expressed genes, or host responses are involved.…”

Section: Introductionmentioning

confidence: 99%

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Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells

et al. 2021

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“…Further, the gut microbiome may increase the risk of contracting HIV ( Coleman et al, 2020 ) via increased expression of integrin and chemokine receptors on T-cells, especially at the level of the colon. Furthermore, it may influence HIV transmission ( Coleman et al, 2020 ), favoring HIV persistence ( Koay et al, 2018 ) through immune activation and systemic inflammation, and impacting the progression from acute HIV infection (AHI; Sortino et al, 2019 ) to AIDS ( Sortino et al, 2019 ), with microbiota diversity correlating with CD4+ T-cell diversity ( Koay et al, 2018 ; Sortino et al, 2019 ). As the disease progresses, an increase in pathogenic species, including Proteobacteria , and a decrease in protective ones (like Bacteroides , Lactobacillus , and Bifidobacterium ) are observed ( Ling et al, 2016 ; Ribeiro et al, 2017 ; Vujkovic-Cvijin et al, 2020 ).…”

Section: The Gut Microbiome and Hiv/aidsmentioning

confidence: 99%

HIV Pre-exposure Prophylaxis and Its Impact on the Gut Microbiome in Men Having Sex With Men

et al. 2022

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HIV/AIDS still imposes a high epidemiological and societal burden. Together with antiretroviral therapy, pre-exposure prophylaxis (PrEP) represents a fundamental tool in the fight against HIV/AIDS. PrEP is considered effective and safe, even though it may affect organs like the kidney, bone, and liver, as shown by randomized clinical trials (RCTs). These side effects may be mediated by alterations of the gut microbiome. Whilst the impact of the human rectal and vaginal microbiome on HIV prevention has been highly investigated among women, less is known about its effect among men having sex with men (MSM), a vulnerable population at high risk for HIV and disproportionately affected by HIV/AIDS. In the present paper, we will overview the effects of PrEP on the gut microbiota in MSM. Mining PubMed/MEDLINE, we identified three studies that have found significant changes affecting the gut microbiota. However, these shifts in the gut microbiome composition are variable, probably due to methodological differences, even though all studies reviewed in the present overview consistently report aberrations at the level of the gut microbiota. More data are needed, especially concerning the long-term side effects of PrEP: despite the studies included being a high-quality RCT, and two well-designed cross-sectional studies, evidence related to the impact of HIV PrEP on the gut microbiome in MSM is scarce and based on small populations. A better understanding of the interactions between the gut microbiota, sexual orientation/identity, and HIV prevention is expected to improve PrEP adherence and devise strategies to counteract PrEP-related side effects.

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“…To date, MSM-derived gut microbiota have no commonly accepted biomarker that is su ciently robust to accurately predict those MSM with HIV-positive statuses [9,12,13]. Importantly, most studies agree that pathogenic changes in gut microbiota could contribute to HIV progression [8, 9,13,14]. However, the MSM status remains a confounding factor in these analyses, for instance, unprotected receptive anal intercourse, enemas or medication [11].…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men

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Sun

et al. 2022

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Background Engaging in anal sexual intercourse markedly increases the risk of developing HIV among men who have sex with men (MSM); oral sexual activities tend to uniquely introduce gut-derived microbes to salivary microbiota, which, combined with an individual’s positive HIV status, may greatly perturb oral microecology. However, till date, only a few published studies have addressed this aspect. Based on 16S rRNA sequencing data of bacterial taxa, MicroPITA picks representative samples for metagenomic analysis, effectively revealing how the development and progression of the HIV disease influences oral microbiota in MSM. Therefore, we collected samples from 11 HIV-negative and 44 HIV-positive subjects (stage 0 was defined by HIV RNA positivity, but negative or indeterminate antibody status; stages 1, 2, and 3 were defined by CD4+ T lymphocyte counts ≥ 500, 200–499, and ≤ 200 or opportunistic infection) and selected 25 representative saliva samples (5 cases/stage) using MicroPITA. DNA extraction, library construction, and metagenomic sequencing analysis were performed to explore whether a positive HIV status changes oral microbiota KEGG functional composition in MSM. Results The core functions of oral microbiota were maintained across each of the five groups, including metabolism, genetic and environmental information processing. All HIV-positive groups displayed KEGG functions of abnormal proliferation, most prominently at stage 0, and others related to metabolism and human disease. Clustering relationship analysis tentatively identified functional relationships between groups, with bacterial function being more similar between stage 0-control groups and stage 1–2 groups, whereas the stage 3 group exhibited large functional changes. Although we identified most metabolic pathways as being common to all five groups, several unique pathways formed clusters for certain groups; the stage 0 group had several, while the stage 2 and 3 groups had few, such clusters. The abundance of K03046 was positively correlated with CD4 counts. Conclusions As HIV progresses, salivary bacterial function in MSM progressively changes as HIV promotes abnormal energy metabolism and exacerbates pathogen virulence. Further, infection and drug resistance of acute stage and immune cell destruction of AIDS stage were abnormally increased, predicting an increased risk for MSM individuals to develop systemic and oral diseases.

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Can gut microbiota of men who have sex with men influence HIV transmission?

Cited by 25 publications

References 56 publications

Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells

Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells

HIV Pre-exposure Prophylaxis and Its Impact on the Gut Microbiome in Men Having Sex With Men

Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men

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Can gut microbiota of men who have sex with men influence HIV transmission?

Cited by 25 publications

References 56 publications

Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5+CD4+T cells

Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5+CD4+T cells

HIV Pre-exposure Prophylaxis and Its Impact on the Gut Microbiome in Men Having Sex With Men

Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men

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Product

Resources

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Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells

Intestinal microbial communities andHoldemanellaisolated from HIV+/− men who have sex with men increase frequencies of lamina propria CCR5⁺CD4⁺T cells