Can hematologic inflammation markers be the indicator of early pregnancy loss?

Onat, Taylan; Kırmızı, Demet Aydoğan; Çaltekin, Melike Demir; Başer, Emre; Yalvaç, Ethem Serdar

doi:10.28982/josam.736881

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Similarly to the research described above, two separate studies compared pregnant women diagnosed with threatened miscarriage and who experienced abortion with healthy pregnant women. Maternal serum NLR and PLR were significantly higher in favor of abortion in both studies 22,23 . These studies differ from the current research in that both were retrospective in design.…”

Section: Discussioncontrasting

confidence: 83%

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An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

Isenlik,

Sarica,

Kaygun

et al. 2024

American J Rep Immunol

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ObjectiveThis study investigated whether serum amyloid A (AA) levels can be used as a biomarker in patients with threatened abortion.Material and MethodsThis prospective cohort study was conducted at the Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, Türkiye, between April and October 2023. Eighty‐eight pregnant women, 44 diagnosed with threatened miscarriage (Group 1) and 44 healthy individuals (Group 2), were included in the study. Sociodemographic, obstetric, and laboratory parameters were compared between the groups.ResultsNo statistically significant differences were observed between the groups in terms of sociodemographic data (age, body mass index, education level, economic status, occupation status, smoking, and alcohol consumption). However, obstetric characteristics (number of pregnancies, living children, miscarriages, dilatation and curettage, gestational age on admission, and fetal crown‐rump length) and laboratory values including complete blood count, hematocrit, leukocyte, neutrophil, lymphocytes, platelet, hs‐C‐reactive protein, neutrophil‐lymphocyte and platelet‐lymphocyte ratio (p > .05), and serum AA values (7.49 ± 3.07 in Group 1 vs. 9.46 ± 4.80 in Group 2, p = .024) differed significantly. Receiver operating characteristic analysis showed that the area under the curve (AUC: 0.662) was statistically significant for serum AA (p = .032), with a cut‐off value of ≥7.51 (95% [confidence interval] 0.516−0.749, sensitivity 65%, specificity 51%). The positive predictive value of serum AA for threatened miscarriage was 56.8%, and the negative predictive value 59.4%.ConclusionThis study shows that serum AA can be used as a biomarker in the diagnosis of threatened miscarriage. Prospective studies involving more participants are now needed to confirm our results.

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Section: Discussioncontrasting

confidence: 83%

“…Mater-nal serum NLR and PLR were significantly higher in favor of abortion in both studies. 22,23 These studies differ from the current research in that both were retrospective in design.…”

Section: Gestational Age On Admission (Week)mentioning

confidence: 65%

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

Isenlik,

Sarica,

Kaygun

et al. 2024

American J Rep Immunol

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Si̇stemi̇k İmmün-İnflamasyon İndeksi̇ni̇n Tubal Ektopi̇k Gebeli̇kteki̇ Rolü

Erten,

Soysal

2024

Kocatepe Tıp Dergisi

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AMAÇ: Çalışmamızda, ektopik gebelik tanısı konan gebeler ile sağlıklı gebeler arasında hematolojik inflamasyon parametrelerinden sistemik immün inflamasyon indeksinin (SII) karşılaştırılması amaçlanmıştır. GEREÇ VE YÖNTEM: Bu retrospektif vaka kontrol çalışması Temmuz 2021 – Ekim 2022 tarihleri arasında üçüncü basamak Eğitim Araştırma Hastanesi’nde yapıldı. 55 tubal toplam ektopik gebeliği olan gebeler ve 106 sağlıklı gebe olmak üzere 161 hasta dahil edildi. Hastaların demografik bilgileri ve laboratuar parametreleri kaydedildi. Hastalar tubal ektopik gebelik ve kontrol grubu olmak üzere iki gruba ayrılıp SII, monosit lenfosit oranı (MLR), nötrofil lenfosit oranı (NLR) ve platelet lenfosit oranı (PLR) inflamasyon markerları açısından karşılaştırıldı. SII değeri şu şekilde hesaplandı: trombosit sayısı x (nötrofil/lenfosit). BULGULAR: Sağlıklı gebelerle karşılaştırıldığında SII, NLR, PLR ve MLR açısıdan ektopik gebelik grubunda anlamlı bir fark bulunmadı (p=0.308, p=0.216, p=0.124 ve p=0.071). Tubal ektopik gebelik grubu incelendiğinde rüptüre ektopik gebeliklerde rüptüre olmayan tubal ektopik gebeliklere göre SII, NLR ve PLR’de anlamlı değişim olmaz iken (p=0.706, 0.354, 0.071) ve MLR düzeyinde azalma bulundu (p=0.018). SONUÇ: Ektopik gebelikteki inflamatuar süreç literatürde sınırlı sayıda çalışma ile halen tartışılmakla birlikte çalışmamızın sonucu olarak tubal ektopik gebelikte SII, NLR, PLR düzeyleri sağlıklı gebelikere göre değişmezken rüptüre ektopik gebeliklerde MLR düzeyinin azaldığını ortaya koyduk.

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Evaluation of complete blood count parameters in the first trimester: an early indicator of miscarriage?

Kale¹,

Helvacıoğlu²,

Muğurtay³

2021

J Clin Invest Surg.

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Objective. Investigation of the relationship between the first trimester complete blood count parameters and miscarriage. Materials and Methods. The study group consisted of 39 patients who admitted to the hospital with the diagnosis of abortus imminens between January 2016 and December 2019, and whose pregnancy ended as miscarriage before the 20th week. The control group consisted of 200 randomly selected healthy pregnant women, with follow-up and delivery in our hospital. Patient information was obtained retrospectively from the hospital records. Results. Age and BMI of both groups were similar. There was no significant difference between the two groups in terms of basophil, neutrophil, eosinophil, lymphocyte, monocyte, platelets, RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, RDW, MPV, Pct and PDW, while leukocyte and neutrophil counts was statistically significantly higher in the miscarriage group (p=0,002, p=0,001, respectively). NLR was statistically higher in the miscarriage group (p=0,005), PLR was also higher in the miscarriage group, but this did not reach statistical significance (p=0,056). Both groups were similar in terms of MLR. Conclusions. High NLR levels obtained from the hemogram results in the first trimester seems to be associated with miscarriage. NLR can be an easy, cheap and useful tool for predicting pregnancy prognosis in patients with abortus imminens.

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Can hematologic inflammation markers be the indicator of early pregnancy loss?

Cited by 3 publications

References 27 publications

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

An evaluation of serum blood parameters and amyloid A levels in pregnant women with threatened miscarriage

Si̇stemi̇k İmmün-İnflamasyon İndeksi̇ni̇n Tubal Ektopi̇k Gebeli̇kteki̇ Rolü

Evaluation of complete blood count parameters in the first trimester: an early indicator of miscarriage?

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