Can homeostatic plasticity in deafferented primary auditory cortex lead to travelling waves of excitation?

Chrostowski, Michael; Yang, Le; Wilson, Hugh R.; Bruce, Ian C.; Becker, Suzanna

doi:10.1007/s10827-010-0256-1

Cited by 40 publications

(40 citation statements)

References 75 publications

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“…Schaette and Kempter (2006) and more recently Noreña (2011) advanced this concept by suggesting that a “homeostatic plasticity mechanism” stabilizes the mean firing rates of CAS neurons around a set point value. Computational studies by Schaette and Kempter (2006), Chrostowski et al (2011), and Noreña (2011) confirm that such a mechanism could explain the increased spontaneous activity that occurs (e.g., in the DCN) in response to sensory deprivation. With this neural homeostasis model, a damaged cochlea would result in reduced output from the auditory nerve, which would, in turn, trigger the amplification of “neural noise,” which would be perceived as tinnitus.…”

Section: Neural Models Of Tinnitusmentioning

confidence: 81%

Underlying Mechanisms of Tinnitus: Review and Clinical Implications

et al. 2014

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Background The study of tinnitus mechanisms has increased tenfold in the last decade. The common denominator for all of these studies is the goal of elucidating the underlying neural mechanisms of tinnitus with the ultimate purpose of finding a cure. While these basic science findings may not be immediately applicable to the clinician who works directly with patients to assist them in managing their reactions to tinnitus, a clear understanding of these findings is needed to develop the most effective procedures for alleviating tinnitus. Purpose The goal of this review is to provide audiologists and other health-care professionals with a basic understanding of the neurophysiological changes in the auditory system likely to be responsible for tinnitus. Results It is increasingly clear that tinnitus is a pathology involving neuroplastic changes in central auditory structures that take place when the brain is deprived of its normal input by pathology in the cochlea. Cochlear pathology is not always expressed in the audiogram but may be detected by more sensitive measures. Neural changes can occur at the level of synapses between inner hair cells and the auditory nerve and within multiple levels of the central auditory pathway. Long-term maintenance of tinnitus is likely a function of a complex network of structures involving central auditory and nonauditory systems. Conclusions Patients often have expectations that a treatment exists to cure their tinnitus. They should be made aware that research is increasing to discover such a cure and that their reactions to tinnitus can be mitigated through the use of evidence-based behavioral interventions.

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Section: Neural Models Of Tinnitusmentioning

confidence: 81%

Underlying Mechanisms of Tinnitus: Review and Clinical Implications

et al. 2014

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“…On the other hand it is possible that psychological stress, current or previous psychiatric disorders, and personality traits associated with a genetically or epigenetically determined vulnerability may represent a vulnerability factor giving rise to maladaptive tinnitus-related neuroplastic rearrangements [135] leading to tinnitus symptomatology. Given the above, our hypothesis is that patients' symptomatology may be considered the peculiar expression of an alteration of global brain hodological equilibrium.…”

Section: Discussionmentioning

confidence: 99%

A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology

et al. 2014

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Introduction. Comorbid psychiatric disorders are frequent among patients affected by tinnitus. There are mutual clinical influences between tinnitus and psychiatric disorders, as well as neurobiological relations based on partially overlapping hodological and neuroplastic phenomena. The aim of the present paper is to review the evidence of alterations in brain networks underlying tinnitus physiopathology and to discuss them in light of the current knowledge of the neurobiology of psychiatric disorders. Methods. Relevant literature was identified through a search on Medline and PubMed; search terms included tinnitus, brain, plasticity, cortex, network, and pathways. Results. Tinnitus phenomenon results from systemic-neurootological triggers followed by neuronal remapping within several auditory and nonauditory pathways. Plastic reorganization and white matter alterations within limbic system, arcuate fasciculus, insula, salience network, dorsolateral prefrontal cortex, auditory pathways, ffrontocortical, and thalamocortical networks are discussed. Discussion. Several overlapping brain network alterations do exist between tinnitus and psychiatric disorders. Tinnitus, initially related to a clinicoanatomical approach based on a cortical localizationism, could be better explained by an holistic or associationist approach considering psychic functions and tinnitus as emergent properties of partially overlapping large-scale neural networks.

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“…These changes can be classed as dynamic modulations of spontaneous and driven neural activity, the underpinnings of which appear to rely upon putatively homeostatic gain-modulation mechanisms that affect the extent of neural excitability, and selectively modulate the balance of excitation and inhibition. Changes at the single neuron and network processing levels can be demonstrated in vivo (e.g., Noreña, 2011; Yang et al, 2011, 2012) and by in silico modeling (Dominguez et al, 2006; Schaette and Kempter, 2006, 2008, 2012; Chrostowski et al, 2011; Tass and Popovych, 2012; Schaette, 2013). Although these neurophysiological sequelae are becoming better understood, it remains an ongoing problem as to whether the various components of central modulation, at different levels of the auditory pathway, might translate into perceptual abnormalities, like tinnitus, that could interrogated by behavioral testing.…”

Section: The Functional and Behavioral Implications Of Trauma-driven mentioning

confidence: 99%

Insult-induced adaptive plasticity of the auditory system

Gold

Bajo

2014

Front. Neurosci.

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The brain displays a remarkable capacity for both widespread and region-specific modifications in response to environmental challenges, with adaptive processes bringing about the reweighing of connections in neural networks putatively required for optimizing performance and behavior. As an avenue for investigation, studies centered around changes in the mammalian auditory system, extending from the brainstem to the cortex, have revealed a plethora of mechanisms that operate in the context of sensory disruption after insult, be it lesion-, noise trauma, drug-, or age-related. Of particular interest in recent work are those aspects of auditory processing which, after sensory disruption, change at multiple—if not all—levels of the auditory hierarchy. These include changes in excitatory, inhibitory and neuromodulatory networks, consistent with theories of homeostatic plasticity; functional alterations in gene expression and in protein levels; as well as broader network processing effects with cognitive and behavioral implications. Nevertheless, there abounds substantial debate regarding which of these processes may only be sequelae of the original insult, and which may, in fact, be maladaptively compelling further degradation of the organism's competence to cope with its disrupted sensory context. In this review, we aim to examine how the mammalian auditory system responds in the wake of particular insults, and to disambiguate how the changes that develop might underlie a correlated class of phantom disorders, including tinnitus and hyperacusis, which putatively are brought about through maladaptive neuroplastic disruptions to auditory networks governing the spatial and temporal processing of acoustic sensory information.

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Can homeostatic plasticity in deafferented primary auditory cortex lead to travelling waves of excitation?

Cited by 40 publications

References 75 publications

Underlying Mechanisms of Tinnitus: Review and Clinical Implications

Underlying Mechanisms of Tinnitus: Review and Clinical Implications

A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology

Insult-induced adaptive plasticity of the auditory system

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