Can HTLV-1 Infection Be a Potential Risk Factor for Atherosclerosis?

Layegh, Parvaneh; Shoeibi, Ali; Nikkhah, K; Juibary, Ali Ghabeli; Raftari, Samaheh; Darbarpanah, Sahar; Boroumand, Reza; Azarpazhooh, Mahmoudreza

doi:10.1159/000365785

Cited by 10 publications

(7 citation statements)

References 18 publications

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“… 11 Furthermore, a cross-sectional study revealed that HTLV-I infection was a risk factor for atherosclerosis, as evaluated by carotid intima-media thickness (IMT). 12 However, its etiology and protective factors are unclear.…”

Section: Introductionmentioning

confidence: 99%

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Kairupan¹,

Ibusuki²,

Kheradmand³

et al. 2017

Journal of Epidemiology

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BackgroundAn increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases.MethodWe selected 2180 sub-cohort subjects aged 35–69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases.ResultsHTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18–7.77).ConclusionThe present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

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Section: Introductionmentioning

confidence: 99%

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Kairupan¹,

Ibusuki²,

Kheradmand³

et al. 2017

Journal of Epidemiology

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“…Our data in this study provide further evidence for this hypothesis that need to be validated in further models of chronic viral infections (e.g., chronic hepatitis and other chronic viral infections). HTLV1 carriers showed a higher carotid intima-media thickness compared to the control group, and HTLV1 infection may consider to be an independent CVD risk factor [30]. Consistent with these findings, Shabestari et al showed that the rate of HTLV1 sero-positivity in individuals who suffered from CVD is about three times higher than the general population [31].…”

Section: Discussionmentioning

confidence: 75%

“…HTLV1 carriers showed a higher carotid intima-media thickness compared to the control group, and HTLV1 infection may consider to be an independent CVD risk factor [30]. Consistent with these findings, Shabestari et al showed that the rate of HTLV1 sero-positivity in individuals who suffered from CVD is about three times higher than the general population [31].…”

Section: Discussionmentioning

confidence: 88%

Human T lymphotropic virus type 1 and risk of cardiovascular disease: High‐density lipoprotein dysfunction versus serum HDL‐C concentrations

et al. 2019

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High-density lipoprotein (HDL) is thought to be protective against cardiovascular disease (CVD), and HDL dysfunction is considered to be a risk factor for CVD. It is unclear whether there is an association between Human T lymphotropic virus type 1 (HTLV1) infection and CVD risk. We have assessed HDL lipid peroxidation (HDLox) as a marker of HDL dysfunction and CVD risk in a subgroup of the MASHAD cohort study. One hundred and sixty two individuals including 50 subjects positive for HTLV1 infection and 112 individuals negative for HTLV1 infection were recruited. Anthropometric and biochemical parameters including serum hs-CRP, fasted lipid profile (HDL-C, LDL, triglycerides, and cholesterol), and fasting blood glucose were determined. Serum HDLox was also measured in the study participants. Multivariate analyses were used to evaluate the association between serum HDLox and HTLV1 infection. None of the traditional CVD risk factors were associated with HTLV1 infection, including serum HDL-C. However, serum HDLox was independently associated with the presence of HTLV1 infection. Logistic regression analysis showed that subjects who were positive for HTLV1 infection were also significantly more likely than uninfected individuals to have higher HDLox (odds ratio 9.35, 95%CI: 3.5–24.7; P < 0.001). HDLox was increased approximately 20% (P < 0.001) in infected subjects compared to the uninfected group. Serum HDLox is a marker of CVD risk factor and increased in individuals affected by HTLV1 infection compared to healthy subjects.

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“…An association between HTLV-1 and atherosclerosis has been reported [12,13], and high-resolution B-mode ultrasound imaging, especially measurement of carotid IMT, has been validated as an indicator of vascular risk [26]. There is no radiation exposure to the patient and it is relatively inexpensive.…”

Section: Discussionmentioning

confidence: 99%

“…Increased IMT is an important predictor of future cerebrovascular and cardiovascular events [11]. A recent study reported an association between atherosclerosis and human T-cell leukemia virus type 1 (HTLV-1) in a population of elderly people in whom IMT was measured [12,13].…”

Section: Introductionmentioning

confidence: 99%

Human T-Cell Leukemia Virus Type 1 Infection Is a Risk Factor for Atherosclerosis

et al. 2021

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Background: Infection, such as by human immunodeficiency virus (HIV), has been reported to cause atherosclerosis by inducing inflammation. Because human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus, as is HIV, we investigated the possible influence of HTLV-1 on the pathogenesis of atherosclerosis by use of established atherosclerosis parameters. Methods: The study was done on Iki Island, Fukuoka, an area endemic for HTLV-1. The data of 1,424 residents who reported to an annual health check were available for analysis. Anti-HTLV-1 antibody status and factors associated with atherosclerosis were examined, including maximum intima-media thickness (Max-IMT) and brachialankle pulse wave velocity (PWV). Results: HTLV-1 positive participants had significantly higher Max-IMT (1.15 ± 0.55 vs. 1.08 ± 0.61 mm, P = 0.04) and PWV (1,760.6 ± 414.5 vs. 1,657.1 ± 425.5 cm/s, P < 0.01) values than did those negative. Moreover, in multiple regression analysis (odds ratio: 1.39, P < 0.01) of participants with Max-IMT 1.1 mm or over, HTLV-1 was extracted as an independent factor for the development of atherosclerosis. Conclusion: Our results indicate that HTLV-1 infection confers a high risk of atherosclerosis, although its opposite relation is also possible. It is important to carefully follow the health status of HTLV-1 carriers.

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Can HTLV-1 Infection Be a Potential Risk Factor for Atherosclerosis?

Cited by 10 publications

References 18 publications

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Human T lymphotropic virus type 1 and risk of cardiovascular disease: High‐density lipoprotein dysfunction versus serum HDL‐C concentrations

Human T-Cell Leukemia Virus Type 1 Infection Is a Risk Factor for Atherosclerosis

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