Can Hybrid Arterial Spin Labeling‐Tagged Zero‐Echo‐Time Magnetic Resonance Angiography Be an Effective Candidate in the Evaluation of Intracranial Artery Diseases? A Clinical Feasibility Study

Abstract

Background Flow related artifacts in continuous arterial spin labeling (cASL) zero‐echo‐time (ZTE) magnetic resonance angiography (MRA) could influence the vasculature visualization. Purpose To investigate the clinical feasibility for the intracranial artery diseases assessment by utilizing hybrid ASL‐ZTE‐MRA (hASL‐ZTE‐MRA). Study Type Prospective, technical development. Population Sixty‐seven subjects with known/suspected cerebrovascular diseases. Field Strength/Sequence Gradient echo based cASL‐/hASL‐ ZTE‐MRA at 3.0 T. Assessment Subjective/objective evaluation for sound‐levels. Image quality (IQ), signal‐to‐noise ratio (SNR), and contrast‐to‐noise ratio (CNR) were analyzed within artery segments. Stenotic grading, aneurysm measurement, and signal intensity of lesions were further analyzed. Statistical Tests Kolmogorov–Smirnov test for data normality check. Between two MRAs: Wilcoxon signed‐rank test for sound experience/IQ ratings analysis; Paired t test for SNR/CNR comparison. One‐way analysis of variance for sound intensity comparison. For stenosis grading/aneurysm measurement: Kendall's W test/intraclass correlation coefficient (ICC) for interobserver agreement test within each modality, weighted kappa statistics/ICC for intermodality agreement test between each MRA and computed tomography angiography. Results Sound‐level perception/intensity was similar (P = 0.86, P = 0.55) between MRAs. The mean IQ score for hASL‐ZTE‐MRA was on diagnostic scale and slightly higher (P < 0.05) than that of cASL‐ZTE‐MRA. hASL‐ZTE‐MRA provided higher (P < 0.05) SNR/CNR than that of cASL‐ZTE‐MRA. Signal uniformity was improved on hASL‐ZTE‐MRA, particularly among the anterior circulation (P < 0.05). Comparing to cASL‐ZTE‐MRA, on hASL‐ZTE‐MRA, stenotic lesions were accurately assessed; flow in the stent or aneurysm remnant was better depicted (P < 0.05); AVM nidus was preferred with increased SNR (P < 0.05). No significant differences for the aneurysm measurement were found between MRAs (P = 0.95), in addition to the slightly higher SNR (P < 0.05) on hASL‐ZTE‐MRA. Data Conclusion Comparing to cASL‐ZTE‐MRA, hASL‐ZTE‐MRA is robust and feasible for the evaluation of intracranial artery diseases with diagnostic IQ, improved vessel contrast, and better signal heterogeneity. Level of Evidence 2 Technical Efficacy 2

Comparative Study of the Diagnostic Value of Zero-Echo-Time Magnetic Resonance Angiography With Time-of-Flight Magnetic Resonance Angiography for Intracranial Aneurysm

“…In these 2 cases, the diagnosis was missed because of the blinding artifacts formed by overlapped images from multiple layer collection. Consistently, previous studies also have indicated that TOF-MRA has disadvantages compared with ZTE-MRA 16,21–23 . In addition, because of the large acoustic noise during scanning, some patients may not be able to tolerate the TOF-MRA procedure.…”

“…Consistently, previous studies also have indicated that TOF-MRA has disadvantages compared with ZTE-MRA. 16,[21][22][23] In addition, because of the large acoustic noise during scanning, some patients may not be able to tolerate the TOF-MRA procedure.…”

Editorial for “Can Hybrid Arterial Spin Labeling‐Tagged Zero‐Echo‐Time Magnetic Resonance Angiography Be an Effective Candidate in the Evaluation of Intracranial Artery Diseases? A Clinical Feasibility Study”

“…7 In this issue of JMRI, Qu et al applied hASL to ZTE-MRA by using additional pulsed labeling straight inferior to the continuous RF pulse followed by an inversion time. 8 They demonstrated improved imaging quality (visual score, SNR, and contrast-to-noise ratio), inter-rater agreement of stenotic grading and aneurysmal size measurement, and acceptable acoustic noise level during hASL-ZTE-MRA compared to CASL-ZTE-MRA. Most notably, the flow in the stent or aneurysm remnant in the posttreated lesions and niduses of arteriovenous malformations were better depicted in the new strategy, suggesting that it could be a reliable option for follow-up after interventions.…”