Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Fırat, Özgür; Kirdok, Ozgur; Makay, Özer; Çalışkan, Cemil; Yılmaz, Funda; Ilgezdi, Savaş; Karabulut, Bülent; Çöker, Ahmet; Zeytunlu, Murat

doi:10.1007/s00534-009-0059-9

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…In the case of acute liver damages, the ALT escalates more significantly than the AST [18]. This result shows that the injection of doxorubicin damages liver cells, corresponding to the results of other studies [6,19].…”

Section: Discussionsupporting

confidence: 82%

Protective effect of mangiferin on doxorubicin-induced liver damage in animal model

Husna¹,

Arozal²,

Yusuf³

et al. 2022

jrp

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Mangiferin is a bioactive compound which has antioxidant effect, but its effect on liver protection during chemotherapy with doxorubicin is understudied. The objective of this study was to assess the protective effect of mangiferin on liver injury induced by doxorubicin. The doxorubicin was injected intraperitoneally at a total dose of 15 mg/kg b.w, and then the animals were orally supplemented with mangiferin (either 50 and 100 mg/kg b.w) for five weeks. The activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), the level of malondialdehyde (MDA) and glutathione, and liver histopathology were examined to evaluate the liver damage. The results showed that doxorubicin could cause liver cell damage to the rats. In addition, the study revealed that the supplementation of mangiferin (50 and 100 mg/kg b.w) decreased ALT and AST activities, as well as lipid peroxidation. It also increased SOD and GSH levels of liver cells (p <0.05). Our study proved that the improvement in liver function and oxidative stress parameters caused by doxorubicin, indicates that the mangiferin has a protective effect against liver damage induced by doxorubicin.

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Section: Discussionsupporting

confidence: 82%

Protective effect of mangiferin on doxorubicin-induced liver damage in animal model

Husna¹,

Arozal²,

Yusuf³

et al. 2022

jrp

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“…However, the use of HBO in combination with DOX is controversial stemming from seminal work by Upton et al where 7 of 8 rats that were treated twice daily with HBO at 2 ATA died by the fourth week after DOX injection [ 24 ]. While the mortality rate in these rats was attributed to excessive free radical formation, this drastic effect on animal survival has not been replicated in subsequent studies [ 25 , 27 ]. Preliminary observations regarding the effects of HBO therapy concurrent with DOX treatment on cardiac function were published in 2008 when Karagoz et al reported partial improvements in ejection fraction and fractional shortening in rats that had received 15 doses of DOX (1 mg/kg/dose) and a 90-min session of HBO at 2.4 ATA 5 days per week over a 4-week period [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, when used as a preventative method, HBO has been shown to improve ischemic tolerance of the brain, spinal cord, liver, heart, and skeletal muscle through increases in antioxidant enzymes and anti-inflammatory proteins [ 6 , 18 , 19 , 20 , 21 ]. However, evidence on the effects of HBO given in combination with DOX treatment is mixed and poorly understood [ 22 , 23 , 24 , 25 , 26 , 27 ]. This study adds to the limited understanding regarding the safety and efficacy of HBO as a therapy to combat DOX myotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hyperbaric Oxygen Preconditioning on Doxorubicin Cardiorespiratory Toxicity

et al. 2022

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Cardiorespiratory dysfunction resulting from doxorubicin (DOX) chemotherapy treatment is a debilitating condition affecting cancer patient outcomes and quality of life. DOX treatment promotes cardiac and respiratory muscle pathology due to enhanced reactive oxygen species (ROS) production, mitochondrial dysfunction and impaired muscle contractility. In contrast, hyperbaric oxygen (HBO) therapy is considered a controlled oxidative stress that can evoke a substantial and sustained increase in muscle antioxidant expression. This HBO-induced increase in antioxidant capacity has the potential to improve cardiac and respiratory (i.e., diaphragm) muscle redox balance, preserving mitochondrial function and preventing muscle dysfunction. Therefore, we determined whether HBO therapy prior to DOX treatment is sufficient to enhance muscle antioxidant expression and preserve muscle redox balance and cardiorespiratory muscle function. To test this, adult female Sprague Dawley rats received HBO therapy (2 or 3 atmospheres absolute (ATA), 100% O2, 1 h/day) for 5 consecutive days prior to acute DOX treatment (20 mg/kg i.p.). Our data demonstrate that 3 ATA HBO elicits a greater antioxidant response compared to 2 ATA HBO. However, these effects did not correspond with beneficial adaptations to cardiac systolic and diastolic function or diaphragm muscle force production in DOX treated rats. These findings suggest that modulating muscle antioxidant expression with HBO therapy is not sufficient to prevent DOX-induced cardiorespiratory dysfunction.

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Amaranthus spinosus (Spiny Pigweed) methanol leaf extract alleviates oxidative and inflammation induced by doxorubicin in male sprague dawley rats

Akinloye

Sulaimon

Ogunbiyi

et al. 2023

ADV TRADIT MED (ADTM)

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Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?

Abstract: Based on our results, we conclude that HBO treatment has the potential to diminish doxorubicin-related hepatotoxicity and improve regeneration in the injured liver.

Cited by 4 publications

References 46 publications

Protective effect of mangiferin on doxorubicin-induced liver damage in animal model

Protective effect of mangiferin on doxorubicin-induced liver damage in animal model

Effects of Hyperbaric Oxygen Preconditioning on Doxorubicin Cardiorespiratory Toxicity

Amaranthus spinosus (Spiny Pigweed) methanol leaf extract alleviates oxidative and inflammation induced by doxorubicin in male sprague dawley rats

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