Can <i>Lactobacillus</i> spp. Be a Factor Reducing the Risk of Miscarriage?

Kiecka, Aneta; Macura, Barbara; Szczepanik, Marian

doi:10.33073/pjm-2021-043

Cited by 7 publications

(7 citation statements)

References 145 publications

(250 reference statements)

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“…has been shown to benefit the effects of assisted reproduction and the women with colonized follicular fluid show changes in the immune response and cytokine profile. The authors therefore proposed the identification of microorganisms in the follicle as a diagnostic test of the true cause of infertility and the prediction of a successful assisted reproduction cycle [102,103]. The bacteria of the genera Pseudomonas, Acinetobacter, Vagococcus and Sphingobium in the fallopian tubes and in the follicles is a poor prognostic factor for IVF, and their presence increases the likelihood of bacterial vaginosis in women with tubal infertility [104].…”

Section: The Microbiota Of Female and Male Reproductive Systemmentioning

confidence: 99%

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Colella

Topi

Palmirotta

et al. 2023

Life

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This article is intended to deepen our knowledge to date regarding the functions of the resident microbiota/microbiome in the urinary system for human health and disease. First, we sought to report the general characteristics (composition and stability) of the normal urinary system microbiota in the different anatomical sites in relation to some factors such as the effect of age, gender and diet, analyzing in detail the functions and the composition of the microbiota in the light of current knowledge. Several pieces of evidence suggest the importance of preserving the micro-ecosystem of the urinary system, and in some cases their relationship with diseases is important for maintaining human health is well understood. The female and male reproductive microbiota have mainly been studied over the past decade. In the past, the arrest was thought to have taken place in a sterile environment. Microorganisms of the microbiota form biofilms, three-dimensional structures, that differ in the reproductive organs and interact with both gametes and the embryo as well as with maternal tissues. These biofilms from the reproductive system also interact with others, such as that of the gastrointestinal tract. Reduction in its diversity intestinal microbiota can disrupt estrogen metabolism and affect the reproductive microbiota. It is therefore understood that its quantitative and qualitative identification is important for microbiota, but also the study of the structures formed by the microorganisms. A dysbiosis with local or systemic causes can lead to serious diseases. The role of probiotics in maintaining microbial population harmony (eubiosis) and preventing certain pathologies of the urinary and reproductive system was also investigated. A negative variation in the qualitative and quantitative composition of certain strains of microorganisms (dysbiosis) due to local or systemic causes can even lead to serious diseases. The role of probiotics in maintaining the healthy balance of microorganism populations (eubiosis), and thus in the prevention of certain pathologies of the urinary and reproductive system, has also been studied.

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Section: The Microbiota Of Female and Male Reproductive Systemmentioning

confidence: 99%

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Colella

Topi

Palmirotta

et al. 2023

Life

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“…Many studies show that Lactobacillus spp. dominates the vaginal microbiota of healthy women (Ravel et al 2011;Gajer et al 2012;Kiecka et al 2021). Due to Lacto bacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Analysis of the Ureaplasma spp. Prevalence with Reference to Other Genital Tract Infections in Women of Reproductive Age

Rak¹,

Kiecka²,

Białecka³

et al. 2022

Polish Journal of Microbiology

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Ureaplasma spp. are frequently isolated from the genital tract of women of reproductive age. To date, it remains unclear whether they are commensal or pathogenic. In our study, we assessed the prevalence of Ureaplasma spp. in a group of 1,155 women of childbearing age. In addition, we assessed how often women with positive Ureaplasma spp. develop genital tract co-infections and how the vaginal pH changes. This study showed a relationship between colonization by Ureaplasma spp. and presenting symptoms. In fact, we showed that colonization of the genital tract by Ureaplasma spp. can affect the occurrence of co-infections such as Gardnerella vaginalis. We also observed a relationship between increased pH values and the presence of Ureaplasma spp.

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“…The first study on the bacterial composition of the uterus reported that real-time quantitative PCR identified 95% of 58 patients undergoing hysterectomy as having a uterine microbiota, with the most common species being L. iners (in 45%) and Prevotella (in 33%) (Mitchell et al, 2015). Several subsequent studies have found that Lactobacillus is the most prominent genus in the endometrium, with Lactobacillus being identified in both endometrial fluid and endometrial biopsies (Franasiak et al, 2016;Moreno et al, 2016;Miles et al, 2017;Moreno and Simon, 2019;Kiecka et al, 2021). It is unclear whether Lactobacillus is an actual endometrial colonizer or whether it ascended from the vagina.…”

Section: Endometrial Microbiomementioning

confidence: 99%

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Elkafas

Wall

Al-Hendy

et al. 2022

Front. Cell. Infect. Microbiol.

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Every year, millions of women are affected by genital tract disorders, such as bacterial vaginosis (BV), endometrial cancer, polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids (UFs). These disorders pose a significant economic burden on healthcare systems and have serious implications for health and fertility outcomes. This review explores the relationships between gut, vaginal, and uterine dysbiosis and the pathogenesis of various diseases of the female genital tract. In recent years, reproductive health clinicians and scientists have focused on the microbiome to investigate its role in the pathogenesis and prevention of such diseases. Recent studies of the gut, vaginal, and uterine microbiomes have identified patterns in bacterial composition and changes across individuals’ lives associated with specific healthy and diseased states, particularly regarding the effects of the estrogen–gut microbiome axis on estrogen-driven disorders (such as endometrial cancer, endometriosis, and UFs) and disorders associated with estrogen deficiency (such as PCOS). Furthermore, this review discusses the contribution of vitamin D deficiency to gut dysbiosis and altered estrogen metabolism as well as how these changes play key roles in the pathogenesis of UFs. More research on the microbiome influences on reproductive health and fertility is vital.

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Can Lactobacillus spp. Be a Factor Reducing the Risk of Miscarriage?

Cited by 7 publications

References 145 publications

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

An Overview of the Microbiota of the Human Urinary Tract in Health and Disease: Current Issues and Perspectives

Retrospective Analysis of the Ureaplasma spp. Prevalence with Reference to Other Genital Tract Infections in Women of Reproductive Age

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

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