Can IGF-1 Serum Levels Really be Changed by Acute Physical Exercise? A Systematic Review and Meta-Analysis

Borba, Diego de Alcântara; Alves, Eduardo da Silva; Rosa, João Paulo Pereira; Facundo, Lucas Alves; Costa, Carlos Alberto da; Silva, Aldo Coelho; Narciso, Fernanda Veruska; Silva, Andressa; Mello, Marco Túlio de

doi:10.1123/jpah.2019-0453

Cited by 23 publications

(17 citation statements)

References 36 publications

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“…There is more reason to believe that exercise facilitates the effectiveness and turnover of these factors and that peripheral levels must not necessarily re ect central ones (brain as main source releasing BDNF (30,82,83,87,93)). This might explain missing acute exercise effects on these factors contrary to other studies (30,39,94). Considering the circadian rhythm, facilitation, and additive effect of IGF-1, marginally higher IGF-1 concentrations post-exercise found here might be more signi cant as they visually and statistically reveal.…”

Section: Neurotrophic and Growth Factorscontrasting

confidence: 87%

“…VEGF has been shown to play a role in exercise-induced adult hippocampal neurogenesis and cognitive improvements (for review : 35). Despite controversial ndings in the literature, human studies and reviews provide consistent evidence that aerobic exercise enhances these neurotrophic and growth factors (35)(36)(37)(38)(39)(40). In previous investigations, decreasing BDNF and increasing IGF-1 level was found during isolation with regular exercise, whereas non-isolated and non-exercising control participants during 60 days of bedrest with or without arti cial gravity exposure did not show any changes (11,41).…”

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confidence: 86%

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Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Abeln

Fomina

Popova

et al. 2022

Preprint

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Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios and social isolation. But to meet both, the common exercise protocols require optimization based on holistic investigations and with respect to underlying processes. This study aimed to clarify individual chronic and acute effects of continuous and interval running exercise on physical and cognitive performance, mood, and affect and to explore underlying neurophysiological factors during a terrestrial simulated space mission.Six volunteers (three females) were isolated for 120 days. Accompanying exercise training consisted of continuous and interval running protocol a cross-over design. Incremental stage tests on a treadmill were done frequently to test physical performance. Actigraphy was used to monitor physical activity level. Cognitive performance, mood (MoodMeter®), affect (PANAS), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular-endothelial growth factor (VEGF), and saliva cortisol were investigated prior to, four times during, and after isolation, pre- and post-exercise on two separate days, respectively. As a chronic effect, physical performance increased (and IGF-1 tended) in the course of isolation and training until the end of isolation. Subjective mood and affect state, as well as cognitive performance, basal BDNF and VEGF levels, were well-preserved across the intervention. No acute effects of exercise were detected, besides slower reaction time after exercise in two out of nine cognitive tests, testing sensorimotor speed and memory of complex figures. Consistently higher basal IGF-1 concentrations and faster reaction time in the psychomotor vigilance test were found for the continuous compared to the interval running protocol. CONCLUSION: The results suggest that 120 days of isolation and confinement can be undergone without cognitive and mental deteriorations. Regular, individual exercise training is hypothesized to play an important role in this regard. Continuous running exercise seems to trigger higher IGF-1 levels and vigilance compared to interval running. Systematic and prolonged investigations and larger sample size are required to follow up on exercise-protocol specific differences in order to optimize the exercise intervention for long-term psycho-physiological health and well-being.

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Section: Neurotrophic and Growth Factorscontrasting

confidence: 87%

mentioning

confidence: 86%

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Abeln

Fomina

Popova

et al. 2022

Preprint

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“…Hormones take part in a complex signaling system and are affected by exogenous stimuli such as CR, energy availability (Loucks and Thuma 2003 ; Mountjoy et al 2018 ), and physical activity (de Alcantara Borba et al 2020 ; Kraemer and Ratamess 2005 ). For instance, CR induces endocrine changes that may negatively affect protein balance and ultimately contributes to lean mass loss.…”

Section: Discussionmentioning

confidence: 99%

Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume

2022

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Many sports employ caloric restriction (CR) to reduce athletes’ body mass. During these phases, resistance training (RT) volume is often reduced to accommodate recovery demands. Since RT volume is a well-known anabolic stimulus, this review investigates whether a higher training volume helps to spare lean mass during CR. A total of 15 studies met inclusion criteria. The extracted data allowed calculation of total tonnage lifted (repetitions × sets × intensity load) or weekly sets per muscle group for only 4 of the 15 studies, with RT volume being highly dependent on the examined muscle group as well as weekly training frequency per muscle group. Studies involving high RT volume programs (≥ 10 weekly sets per muscle group) revealed low-to-no (mostly female) lean mass loss. Additionally, studies increasing RT volume during CR over time appeared to demonstrate no-to-low lean mass loss when compared to studies reducing RT volume. Since data regarding RT variables applied were incomplete in most of the included studies, evidence is insufficient to conclude that a higher RT volume is better suited to spare lean mass during CR, although data seem to favor higher volumes in female athletes during CR. Moreover, the data appear to suggest that increasing RT volume during CR over time might be more effective in ameliorating CR-induced atrophy in both male and female resistance-trained athletes when compared to studies reducing RT volume. The effects of CR on lean mass sparing seem to be mediated by training experience, pre-diet volume, and energy deficit, with, on average, women tending to spare more lean mass than men. Potential explanatory mechanisms for enhanced lean mass sparing include a preserved endocrine milieu as well as heightened anabolic signaling.

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“…However, other studies [ 74 , 75 , 76 ] have shown that high values of IGF-1 are associated with higher levels of depression. Likewise, a recent meta-analysis showed that higher levels of IGF-1 are found in aerobic exercise over strength training [ 77 ]. This background may partly explain why there are more significant benefits for depression through conventional strength training than through concurrent and aerobic training.…”

Section: Discussionmentioning

confidence: 99%

Effects of Training with Different Modes of Strength Intervention on Psychosocial Disorders in Adolescents: A Systematic Review and Meta-Analysis

Barahona-Fuentes

Ojeda

Chirosa

2021

IJERPH

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Physical exercise has a positive impact on anxiety and depression. However, the evidence that associates strength training with a decrease in adolescents’ psychosocial disorders is scarce. Consequently, the objective was to analyze the effects of training with different modes of strength intervention on anxiety, stress, and depression in adolescents. The search was designed according to PRISMA®. We searched WoS, Scopus, SPORTDiscus, PubMed, and MEDLINE (2010–2020). Methodological quality and risk of bias were assessed with the Cochrane Collaboration. The analysis was carried out with a standardized mean difference (SMD) pooled using the Hedges g test (95% CI). The Main Outcome Measures were: anxiety, stress, and depression in adolescents post strength training. Nine studies were included in the systematic review and seven in the meta-analysis. These studies showed a large and significant effect of strength training on anxiety (SMD = −1.75; CI = 95%: −3.03, −0.48; p = 0.007) and depression (SMD = −1.61; CI = 95%: −2.54, −0.67, p = 0.0007). In conclusion, training with different modes of strength intervention have shown control over anxiety and depression in adolescents. However, conventional strength training seems to have better results than other modes of strength intervention.

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Can IGF-1 Serum Levels Really be Changed by Acute Physical Exercise? A Systematic Review and Meta-Analysis

Cited by 23 publications

References 36 publications

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement

Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume

Effects of Training with Different Modes of Strength Intervention on Psychosocial Disorders in Adolescents: A Systematic Review and Meta-Analysis

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