Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?

Bonekamp, Susanne; Kamel, Ihab R.; Solga, Steven F.; Clark, Jeanne M.

doi:10.1016/j.jhep.2008.10.016

Cited by 178 publications

(147 citation statements)

References 185 publications

(203 reference statements)

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“…These include double contrast-enhanced MRI [20], MR elastography [8,21] and diffusion-weighted imaging [8,22]. These techniques' sensitivity for early liver fibrosis, reproducibility and intersite variability have not been well established [23].…”

Section: Discussionmentioning

confidence: 99%

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Deng

Zhao²,

Yuan³

et al. 2012

BJR

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Objectives: The aim of this study was to explore the technical feasibility of T 1 r MRI for the liver, and to determine the normal range of liver T 1 r in healthy subjects at clinical 3 T. Methods: There were 15 healthy volunteers. Three representative axial slices were selected to cut through the upper, middle and lower liver. A rotary echo spin-lock pulse was implemented in a two-dimensional fast-field echo sequence. Spin-lock frequency was 500 Hz, and the spin-lock times of 1, 10, 20, 30, 40 and 50 ms were used for T 1 r mapping. The images were acquired slice by slice during breath-holding. Regions of interest (ROIs; n55) were manually placed on each slice of the liver parenchyma region, excluding artefacts and vessels. The mean value of these ROIs (n515) was regarded as the liver T 1 r value for the subject. Six subjects were scanned once at fasting status; six subjects were scanned once 2 h post meal; three subjects were scanned twice at fasting status; and seven subjects were scanned twice 2 h post meal. Results: When two readers measured the same 10 data sets, the interreader reproducibility (ICC: intraclass correlation coefficient) was 0.955. With the 10 subjects scanned twice, the ICC for scan-rescan reproducibility was 0.764. There was no significant difference for the liver T 1 r value at the fasting status (43.08¡1.41 ms) and post-meal status (42.97¡2.38 ms, p50.867). Pooling together all the 32 scans in this study, the normal liver T 1 r value ranged from 38.6 to 48.3 ms (mean 43.0 ms, median 42.6 ms). Conclusion: It is feasible to obtain consistent liver T 1 r measurement for human subjects at 3 T.

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Section: Discussionmentioning

confidence: 99%

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Deng

Zhao²,

Yuan³

et al. 2012

BJR

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“…USG-based diagnosis of liver cirrhosis can be based on hepatic and extra-hepatic signs, and the accuracy of USG varies across different studies also because of the different parameters examined (Aube et al, 1999). There is no approved score for ultrasonographic diagnosis of cirrhosis, thus in common practice the diagnosis is made at the examining physician's discretion (Bonekamp et al, 2009). In the present study, it was decided on the basis of the authors' experience that the presence of at least three ultrasonographic signs (one of which must be nodular surface of the liver) is reliable for liver cirrhosis diagnosis.…”

Section: Endoscopymentioning

confidence: 99%

Liver cirrhosis in patients newly diagnosed with neurological phenotype of Wilson�s disease

Przybyłkowski¹

2014

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SummaryWilson's disease (WD) can manifest itself in different clinical forms, the neurological and hepatic ones being the most common. It is suggested that neurological signs and psychiatric symptoms develop secondary to liver involvement. The aim of this study was to characterize the liver disease in patients newly diagnosed with the neurological form of WD. Treatment-naive patients diagnosed with WD were classified into three phenotypic groups: hepatic, neurological and pre-symptomatic. Liver involvement was ascertained through surrogate markers: abdominal ultrasound and laboratory parameters. In addition, study participants were screened for esophageal varices. Of 53 consecutively diagnosed WD patients, 23 individuals (43.4%) had a predominantly neurological presentation. In this group, cirrhosis was diagnosed in 11 (47.8%) subjects. Esophageal varices were present in all of them. In every patient with neurological WD, there was at least one sign of hepatic disease on ultrasound examination, indicating universal presence of liver involvement. The prevalence of surrogate signs of cirrhosis was similar in patients with the neurological and in those with the hepatic phenotype.

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“…Other procedures, e.g. magnetic resonance elastography for measurement of fibrosis (Bonekamp et al, 2009), are currently inadequately validated or not validated at all, and therefore cannot be recommended. Although liver biopsy is superior to all other investigations with regard to number of relevant parameters assessed and predictive power, it cannot always be recommended as diagnostic method in possible or sufficiently confirmed fatty liver disease.…”

Section: Indication For Biopsymentioning

confidence: 99%

Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

et al. 2011

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Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?

Cited by 178 publications

References 185 publications

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Liver cirrhosis in patients newly diagnosed with neurological phenotype of Wilson�s disease

Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

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Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?

Cited by 178 publications

References 185 publications

LiverT1ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT1ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Liver cirrhosis in patients newly diagnosed with neurological phenotype of Wilson�s disease

Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease

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LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence