Can immature granulocytes indicate mortality in patients with acute ischemic stroke?

Abstract

Background & Objective: Stroke is the most common cause of permanent disability and the most important cause of mortality. Acute ischemic stroke (AIS) reveals inflammation in the ischemic brain tissue. Ischemic tissue causes proinflammatory cytokine release and aggregation of immune cells. Therefore in this study, we aimed to investigate the role of immature granulocyte (IG) in showing 30-day mortality in patients with AİS. Methods: This study was designed as a single-centered, retrospective cohort study. Patients aged >18 years who were diagnosed with AIS in the tertiary emergency department were included in this study. Patients were divided into two groups as low (<0.6%) and high (≥0.6%) by IG values. Demographic and laboratory parameters were compared between the groups at admission to the emergency department. Results: Our study consisted of 172 patients diagnosed with AIS, who met the inclusion criteria. The average age of the study group was 69.19 ± 14.34 years, and 94 (54.7%) of the patients were male. 98 (56.9%) patients were in the low IG group, and 74 (43.1%) of them were in the poor outcome group. IG at the cut-off value of 1.3 was shown to predict mortality in patients with AIS with 80.5% sensitivity and 93.2% specificity (area under the curve: 0.715 95% CI: 0.623-0.807, p <0.001) Conclusion: The results of our study showed that IG is a new and simple predictor to predict 30-day prognosis in patients with AIS.

Immature granulocyte and other markers in prediction of the short-term and long-term prognosis of patients with acute ischemic stroke

“…7 Moreover, Korkut et al found that high IG levels were significantly associated with 30-day mortality in AIS. 5 Our study showed a statistically significant correlation between high IG value and short-term mortality in cases with AIS. In univariate and multivariate Cox regression analyses, IG% was an independent predictor of short-term mortality.…”

“…4 Whereas, only one study observes the relationship between IG and the 30-day mortality of AIS patients. 5 However, we could not find an article in the literature investigating the connection between immature granulocyte and long-time period mortality in patients with AIS. Therefore, we aimed to investigate the function of IG and other labels in predicting short-and long-time mortality in patients with AIS.…”

Can immature granulocyte (IG), an inflammatory marker, be used in the differential diagnosis of epilepsy and non-epileptic psychogenic seizure?

“…In their study, Korkut et al showed that the IG count effectively shows 30-day mortality in ischemic stroke patients. 22 Bedel et al found that the IG count was significantly associated with poor prognosis in spontaneous intracerebral hemorrhage. 23 In addition, in a recent study, it was shown that the IG count is effective in predicting hospital mortality in spontaneous intracerebral hemorrhage.…”

Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage

“…Recently, it has been discovered that the number and percentage of IG in peripheral blood help to predict complications and mortality in many diseases, such as sepsis, septic shock, local infection, coronary artery disease, acute appendicitis, and pancreatitis (3,4). Moreover, in one study, IG was associated with 30-day mortality in acute ischemic stroke (5). However, there is only one study on IG in the literature to predict mortality in patients with SICH, and the relationship between 30-day mortality and IG has been investigated (6).…”