Can improvements in sleep quality positively affect serum adiponectin-levels in patients with obstructive sleep apnea?

Magnusdottir, Solveig; Thomas, Robert J.; Hilmisson, Hugi

doi:10.1016/j.sleep.2021.05.032

Cited by 10 publications

(6 citation statements)

References 66 publications

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“…Adiponectin levels were also lower in a group of patients with severe OSAS [46]. A recent study also showed that improvement in sleep quality is associated with increased serum adiponectin levels and improved indices of glycemic control [47]. Conversely, chronic sleep deprivation was associated with higher adiponectin levels in a cross-section study among patients with metabolic diseases, after adjusting for age, sex, BMI, hypertension, menopause, and exercise levels [48].…”

Section: Adiponectinmentioning

confidence: 89%

Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

Wei

Chen

Upender

2022

IJMS

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Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.

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Section: Adiponectinmentioning

confidence: 89%

Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

Wei

Chen

Upender

2022

IJMS

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“…Second, instead of an objective actigraphic or polysomnographic instrument, we adapted a single self-reported questionnaire to measure sleep duration, which may lead to sleep recall bias. Nonetheless, the previous studies revealed that both self-reported and objective measurements of sleep quality were significantly associated with an increased risk of MetS [ 48 , 49 ]. Third, although we controlled for some confounding variables including age, gender, current drinking and smoking status, we lacked relevant information about sleep apnea, which might play a role in the relationship of sleep quality with MetS.…”

Section: Discussionmentioning

confidence: 99%

Association of Sleep Duration and Self-Reported Insomnia Symptoms with Metabolic Syndrome Components among Middle-Aged and Older Adults

Zhang

Xie

Huang

et al. 2022

IJERPH

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The study aimed to explore the association between sleep duration, insomnia symptoms and the components of metabolic syndrome (MetS) among middle-aged and older adults. A cross-sectional study was conducted in five community health centers and physical check-up centers of two comprehensive hospitals in Guangdong. We recruited 1252 participants (658 female), aged 40–96 years and with a body mass index (BMI) of 16.26–35.56 kg/m2. MetS was assessed based on the guidelines of the International Diabetes Federation. Self-reported sleep duration was evaluated by a simplified questionnaire. Compared with the participants who slept 6–8 h/day, those who slept shorter (<6 h/day) or longer (>8 h/day) periods of time with or without insomnia symptoms had significantly increased odds ratios (ORs) of high blood pressure (except for the SBP in model 2) and high triglycerides (TGs) in all models (p < 0.05), whereas the participants who slept longer (>8 h/day) or shorter (<6 h/day) periods of time with insomnia symptoms had significantly increased ORs of low HDL-C in all models (p < 0.05), but non-significant in those without insomnia symptoms. BMI is significant for insomnia symptoms but not for sleep duration. Our study indicated that the association of sleep duration with MetS components was partially associated with insomnia symptoms. These findings have significant implications to explore the appropriate sleep duration for adults.

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“…Similar results have been observed in cardiomyocytes, neurons, and pulmonary cells ( 212 – 214 ). Improving sleep quality in OSA patients with cardiovascular disease either by CPAP, nocturnal supplemental oxygen, or sleep hygiene education significantly increased serum adiponectin levels and improved glucose tolerance parameters ( 215 ). Therefore, low serum adiponectin in OSA may contribute to their higher risk of systemic complications including renal impairment and insulin resistance.…”

Section: Sleep Apnea Obesity and Ckdmentioning

confidence: 99%

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

et al. 2023

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Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus and hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting a myriad of cytokines and adipokines that contribute to insulin resistance and induce a chronic low-grade inflammatory state thereby damaging the kidney. CKD development itself is associated with various metabolic alterations that exacerbate adipose tissue dysfunction and insulin resistance. This adipose-renal axis is a major focus of current research, given the rising incidence of CKD and obesity. Cellular senescence is a biologic hallmark of aging, and age is another significant risk factor for obesity and CKD. An elevated senescent cell burden in adipose tissue predicts renal dysfunction in animal models, and senotherapies may alleviate these phenotypes. In this review, we discuss the direct mechanisms by which adipose tissue contributes to CKD development, emphasizing the potential clinical importance of such pathways in augmenting the care of CKD.

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Can improvements in sleep quality positively affect serum adiponectin-levels in patients with obstructive sleep apnea?

Cited by 10 publications

References 66 publications

Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines

Association of Sleep Duration and Self-Reported Insomnia Symptoms with Metabolic Syndrome Components among Middle-Aged and Older Adults

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

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