Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?

Wen, Jinxiu; Huang, Kecheng; Du, Xiaofang; Zhang, Hanwang; Ding, Ting; Zhang, Cuilian; Ma, Wenzhi; Zhong, Ying; Qu, Wei; Yi, Liu; Li, Zhiying; Deng, Song; Luo, Aiyue; Jin, Yan; Zhang, Jinjin; Wang, Shixuan

doi:10.3389/fendo.2021.626534

Cited by 18 publications

(15 citation statements)

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“…Moreover, due to different populations and detection kits in different studies and small sample sizes, the absolute values of inhibin B concentrations were also different. However, in the previous study, serum levels of inhibin B are positively correlated with AFC ( 6 ). Thus, we can assume that the decrease in serum levels of inhibin B in our study is per se associated with RAI treatment.…”

Section: Discussionmentioning

confidence: 62%

“…The assessment of the ovarian reserve can be based on different hormonal markers, dynamic tests, and ultrasonographic (USG) parameters, for example, antral follicle count (AFC). Markers such as the serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), or inhibin B are relatively good prognostic markers for fertility and reliable markers for the assessment of the functional ovarian reserve ( 4 , 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Adamska

Tomczuk-Bobik

Popławska-Kita

et al. 2021

Endocrine Connections

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Treatment with radioactive iodine (RAI) in women with differentiated thyroid cancer is associated with decreased serum concentrations of anti-Müllerian hormone (AMH); however, other markers have not been investigated. Therefore, this study aimed to evaluate the effect of RAI on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the participants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and one year after RAI treatment. We found decreased AFC (p = 0.03), serum levels of AMH (p < 0.01), inhibin B (p = 0.03), but not FSH (p = 0.23), one year after RAI treatment in comparison to baseline in the whole group. When we compared serum levels of AMH in younger vs. older women separately, we observed a significant reduction of this hormone’s serum level after RAI treatment in both groups (p < 0.01; p = 0.04, respectively). We concluded that RAI treatment significantly impacts the functional ovarian reserve in premenopausal women with PTC.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Adamska

Tomczuk-Bobik

Popławska-Kita

et al. 2021

Endocrine Connections

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“…Serum levels of AMH (ng/ml) and inhibin B (pg/ml) were measured using AMH and inhibin B ELISA kits (Beckman Coulter Inc., Sacramento, CA, USA). Protocols were described in previous studies ( 26 , 27 ).…”

Section: Methodsmentioning

confidence: 99%

Vaginal Microbiota Changes in Patients With Premature Ovarian Insufficiency and Its Correlation With Ovarian Function

Wen¹,

Feng²,

Yan³

et al. 2022

Front. Endocrinol.

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ObjectivesTo reveal the characteristics of vaginal microbiota in premature ovarian insufficiency (POI) patients and their relationship with ovarian function.Materials and MethodsIn this case-control study, the vaginal bacterial composition of 30 POI patients and 26 healthy women of comparable age was assessed by 16S rRNA gene sequencing targeting the V3-V4 hypervariable regions. The metabolic functions of vaginal microflora were preliminarily predicted through the PICRUSt2 analysis. Redundancy analysis and Spearman’s correlation analyzed the relationships between vaginal microbiota and ovarian function indicators.ResultsActinobacteria, Atopobium, and Gardnerella were significantly increased in POI patients. Their increments were significantly negatively correlated with anti-müllerian hormone (AMH) and inhibin B, and positively correlated with follicle-stimulating hormone (FSH) and luteinizing hormone (LH). While Bifidobacterium was significantly decreased in POI patients. Its relative abundance was significantly positively correlated with AMH and negatively correlated with FSH and LH. Then, POI patients included in this study were divided into POI (25 < FSH ≤ 40) (n = 9) and premature ovarian failure (POF) (FSH > 40) (n = 21) subgroups according to serum FSH levels. Compared with the controls, Firmicutes and Lactobacillus were significantly decreased only in POF (FSH > 40) patients, while no difference was observed in POI (25 < FSH ≤ 40) patients. Lactobacillus was negatively correlated with FSH. Firmicutes was significantly reduced and Actinobacteria was significantly increased in POF (FSH > 40) patients compared with POI (25 < FSH ≤ 40) patients. The key bacterial taxa Gardnerella and Atopobium showed potency in predicting POI.ConclusionsHere we demonstrated significant changes in the vaginal microbiota of POI patients, and these changes were significantly correlated with reduced ovarian reserve, endocrine disruption, and symptoms of perimenopausal syndrome. Differences in vaginal microbiota between POI (25 < FSH ≤ 40) and POF (FSH > 40) patients were also identified. These findings may provide new evidence for the relationship between vaginal microbiota and ovarian function.

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“…The level of Inhibin B in women is derived from granulosa cells, and it directly reflects the ovarian reserve during the follicular phase of the menstrual cycle. Inhibin B levels are lower in older women compared to young ones (Wen et al, 2021). Reductions in serum levels of Inhibin B constitute one of the early signs of a reduction in (or the loss of) the ovarian reserve, and it occurs with increasing age and Body Mass Index (BMI) (Wang et al, 2022).…”

Section: Open Access | Research Notes Issn: 2576-828xmentioning

confidence: 99%

Investigating the relationship between infertility and depression in women

Karimpour

Miladpour

2022

Neurosci Res Notes

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Depression plays a clear and undeniable role in infertility. In this study, we investigated the status of depression and the levels of fertility hormones in infertile women. One hundred infertile women and 50 fertile controls participated in this study. The serum levels of cortisol, anti-mullerian hormone (AMH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and inhibin B markers were measured using electro-quantitative luminescence and ELISA techniques. The results showed a significant difference between the case and control groups in terms of the serum levels of LH, FSH, and AMH (P-value˂ 0.05). Depression was significantly associated with AMH in infertile women (P-value = 0.049). AMH and FSH showed a significant difference between the two groups of depressed fertile and depressed infertile women (P-value = 0.005, P-value = 0.042, respectively). In addition, there was a significant difference between the two groups regarding depression status (P-value = 0.003). We concluded that depression might affect AMH, FSH levels, and infertility. As a result, examining all the important and relevant markers of infertility and paying attention to the psychological conditions of women are highly important. Thus, it is possible to prioritize these cases to improve couples' fertility.

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Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?

Cited by 18 publications

References 50 publications

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Vaginal Microbiota Changes in Patients With Premature Ovarian Insufficiency and Its Correlation With Ovarian Function

Investigating the relationship between infertility and depression in women

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