Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Freed, Catherine; Adepoju, Olusegun A.; Gillaspy, Glenda E.

doi:10.3390/plants9010115

Cited by 21 publications

(25 citation statements)

References 77 publications

(144 reference statements)

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“…Table 2 lists a number of documented methods of phytate removal from plant proteins, including pH adjustment, membrane technology, ionic exchange, phytase treatment, bioprocesses, γ‐irradiation, and so on. Genetic modification and breeding are also promising approaches to obtaining low‐phytate grains for the production of low‐phytate food and feedstuff (Freed, Adepoju, & Gillaspy, 2020; Raboy, 2007).…”

Section: Phytate and Food Processingmentioning

confidence: 99%

Phytic acid and its interactions: Contributions to protein functionality, food processing, and safety

Wang

Guo

2021

Comp Rev Food Sci Food Safe

107

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Is phytic acid (IP6) an undesirable constituent for vegetables and foods? This question is getting harder to answer. Phytic acid contributes to mineral/protein deficiency, but also brings about potential physiological benefits. Both the positive and negative effects boil down to the interactions among IP6, metal ions, and biopolymers. In the wake of the booming market of plant‐based foods, an unbiased understanding of these interactions and their impacts on the foods themselves is a necessity to the smart control and utilization of plant‐sourced phytates. This overview presents updated knowledge of IP6‐related interactions, with a strong focus on their contributions to food functionality, processability, and safety.

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Section: Phytate and Food Processingmentioning

confidence: 99%

Phytic acid and its interactions: Contributions to protein functionality, food processing, and safety

Wang

Guo

2021

Comp Rev Food Sci Food Safe

107

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“…A small pool of PA present in the cell is further phosphorylated to form PP-InsP, containing one or two diphosphate groups (InsP 7 and InsP 8 , respectively). PP-InsP have important roles in energy metabolism, hormone signaling (mainly jasmonate), and Pi sensing ( Freed et al, 2020 ). A recent review pointed out that different Arabidopsis lpa mutations affecting PA biosynthetic genes, also cause a reduction in the content of InsP 8 and in some cases of InsP 7 .…”

Section: Pleiotropic Effects Of Lpa Mutations Inmentioning

confidence: 99%

“…A recent review pointed out that different Arabidopsis lpa mutations affecting PA biosynthetic genes, also cause a reduction in the content of InsP 8 and in some cases of InsP 7 . Due to the important role of these molecules, a decrease in their content may affect pathogen response and Pi sensing ( Freed et al, 2020 ). On the other hand, the Arabidopsis mrp5 and the maize lpa1 mutants show increased content of both InsP 7 and InsP 8 .…”

Section: Pleiotropic Effects Of Lpa Mutations Inmentioning

confidence: 99%

“…On the other hand, the Arabidopsis mrp5 and the maize lpa1 mutants show increased content of both InsP 7 and InsP 8 . Hence, from this point of view, PA-MRP genes can be considered an interesting target for the development of lpa mutants not compromised in P homeostasis and in jasmonate signaling ( Freed et al, 2020 ).…”

Section: Pleiotropic Effects Of Lpa Mutations Inmentioning

confidence: 99%

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MRP Transporters and Low Phytic Acid Mutants in Major Crops: Main Pleiotropic Effects and Future Perspectives

et al. 2020

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Phytic acid (PA) represents the major storage form of seed phosphate (P). During seed maturation, it accumulates as phytate salts chelating various mineral cations, therefore reducing their bioavailability. During germination, phytase dephosphorylates PA releasing both P and cations which in turn can be used for the nutrition of the growing seedling. Animals do not possess phytase, thus monogastric animals assimilate only 10% of the phytate ingested with feed, whilst 90% is excreted and may contribute to cause P pollution of the environment. To overcome this double problem, nutritional and environmental, in the last four decades, many low phytic acid (lpa) mutants (most of which affect the PA-MRP transporters) have been isolated and characterized in all major crops, showing that the lpa trait can increase the nutritional quality of foods and feeds and improve P management in agriculture. Nevertheless, these mutations are frequently accompanied by negative pleiotropic effects leading to agronomic defects which may affect either seed viability and germination or plant development or in some cases even increase the resistance to cooking, thus limiting the interest of breeders. Therefore, although some significant results have been reached, the isolation of lpa mutants improved for their nutritional quality and with a good field performance remains a goal so far not fully achieved for many crops. Here, we will summarize the main pleiotropic effects that have been reported to date in lpa mutants affected in PA-MRP transporters in five productive agronomic species, as well as addressing some of the possible challenges to overcome these hurdles and improve the breeding efforts for lpa mutants.

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“…The MRP5 gene product of Arabidopsis encodes an ABC transporter that most likely functions to transport InsP 6 across the vacuolar membrane during seed development, allowing high amounts of InsP 6 to be stored in the seed [10]. At present we have a good understanding of the synthesis and transport of InsP 6 within plants, due to the presence of key Arabidopsis mutants that are defective in InsP kinases [11] or the Atmrp5 gene [10]. A third major difference is that plants have no known Ins(1,4,5)P 3 receptor that could serve to release intracellular calcium stores in response to signaling-stimulated hydrolysis of phosphatidylinositol(4,5)P 2 (PtdIns(4,5)P 2 ) [12].…”

Section: Introductionmentioning

confidence: 99%

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?

Cridland

Gillaspy

2020

Molecules

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The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP) signaling pathway. In plants and humans the pyrophosphorylated inositol molecules, inositol pyrophosphates (PP-InsPs), have been implicated in phosphate and energy sensing. PP-InsPs are synthesized from the phosphorylation of InsP6, the most abundant InsP. The plant PP-InsP synthesis pathway is similar but distinct from that of the human, which may reflect differences in how molecules such as Ins(1,4,5)P3 and InsP6 function in plants vs. animals. In addition, PP-InsPs can potentially interact with several major signaling proteins in plants, suggesting PP-InsPs play unique signaling roles via binding to protein partners. In this review, we will compare the biosynthesis and role of PP-InsPs in animals and plants, focusing on three central themes: InsP6 synthesis pathways, synthesis and regulation of the PP-InsPs, and function of a specific protein domain called the Syg1, Pho1, Xpr1 (SPX ) domain in binding PP-InsPs and regulating inorganic phosphate (Pi) sensing. This review will provide novel insights into the biosynthetic pathway and bioactivity of these key signaling molecules in plant and human systems.

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Can Inositol Pyrophosphates Inform Strategies for Developing Low Phytate Crops?

Cited by 21 publications

References 77 publications

Phytic acid and its interactions: Contributions to protein functionality, food processing, and safety

Phytic acid and its interactions: Contributions to protein functionality, food processing, and safety

MRP Transporters and Low Phytic Acid Mutants in Major Crops: Main Pleiotropic Effects and Future Perspectives

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?

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