Can insoluble polysaccharide concentration in dental plaque, sugar exposure and cariogenic microorganisms predict early childhood caries? A follow-up study

Parisotto, Thaís Manzano; Stipp, Rafael Nóbrega; Rodrigues, Lidiany Karla Azevedo; Mattos-Graner, Renata O.; Costa, Leandro Silva; Nobre‐dos‐Santos, Marinês

doi:10.1016/j.archoralbio.2015.04.003

Cited by 26 publications

(23 citation statements)

References 29 publications

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“…These studies involving children have shown that ECC is associated with increases in the proportions of acidogenic bacteria and high acidogenic potential, in agreement with the ecological plaque hypothesis of caries [Marsh, 2006]. Considering that the presence of S. mutans in biofilms in ECC is associated with a high level of sucrose exposure [Parisotto et al, 2010[Parisotto et al, , 2015, our data suggest that ECC children are subjected to additional dietary sugar challenges than only lactose from milk [Hallonsten et al, 1995]. However, ECC and caries-free children did not differ regarding resting biofilm pH.…”

Section: Discussionsupporting

confidence: 64%

Breastfeeding, Dental Biofilm Acidogenicity, and Early Childhood Caries

Neves

Ribeiro²,

Tenuta

et al. 2016

Caries Res

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Aim: This study evaluated the acidogenicity of human milk by the dental biofilms of children with and without early childhood caries (ECC). Method: Biofilms of 16 children (7 with ECC; 9 caries free) were exposed to human milk or 10% sucrose solution in the crossover design, and the biofilm pH was determined. Results: Breastfeeding did not provoke a decrease in biofilm pH, irrespective of the children's caries status, whereas sucrose decreased the pH for both groups. In addition, higher ΔpH_5min (pH variation occurring at 5 min) was observed in the biofilms of ECC children (p < 0.05). The results suggest that breastfeeding may not contribute to ECC.

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Section: Discussionsupporting

confidence: 64%

Breastfeeding, Dental Biofilm Acidogenicity, and Early Childhood Caries

Neves

Ribeiro²,

Tenuta

et al. 2016

Caries Res

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“…The biological importance of S. mutans as the etiologic agent of dental caries in children and as one of the most commonly isolated pathogenic microorganisms in dental plaque and saliva, has been studied for decades in dentistry (19). A systematic review showed that S. mutans levels are strong risk factors for ECC and a longitudinal study confirmed this (20).…”

Section: An Early Childhood Caries Studymentioning

confidence: 49%

“…The variation in the amount of cariogenic microorganisms in children is related to dietary practices, especially to sucrose frequency ingested by the child (19). However, the high salivary levels of S. mutans, as a predictor of caries in childhood, cannot be considered separately.…”

Section: An Early Childhood Caries Studymentioning

confidence: 99%

A Longitudinal Study of Early Childhood Caries and Associated Factors in Brazilian Children

Piva

Pereira

Luz³

et al. 2017

Braz. Dent. J.

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Early childhood caries (ECC) affects children all over the world and has high prevalence and severity in preschool children. Different social, biological and behavioral factors compose a network of causal factors for ECC. The aim was to evaluate the association between socioeconomic variables and caries at baseline, and the presence of Streptococcus mutans and Lactobacillus spp. microorganisms with the progression of caries lesions after two years of follow-up in a group of children. At baseline, 163 children (3-4 years old) living in the areas of 12 primary care services of the Hospital Group Conceição (GHC, Porto Alegre, RS, Brazil) were evaluated. After two years, 119 children were re-evaluated. Clinical examinations were conducted by calibrated examiners using the ICDAS criteria. A sociodemographic questionnaire was applied to the children's parents and saliva samples were collected from the children for microbiological analysis. Descriptive statistics and multivariate Poisson regression analysis were performed in the statistical analysis. The factors associated with the caries progression were marital status of mothers (p=0.040), higher S. mutans counts (p=0.031) and the presence of cavitated lesions at baseline (p<0.001). The caries lesions progression in preschool children enrolled in primary health care was directly associated with marital status, presence of cavitated lesions at baseline and higher S. mutans counts at two-year follow-up.

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“…This result can partially be explained if we take into account that children with caries are more frequently exposed to sucrose, a specific substrate for production of extracellular insoluble polysaccharides and a pH drop in the oral cavity [Parisotto et al, 2015]. This pH drop would activate salivary CA VI.…”

Section: Discussionmentioning

confidence: 99%

Children with a Higher Activity of Carbonic Anhydrase VI in Saliva Are More Likely to Develop Dental Caries

Picco¹,

Lopes²,

Marques³

et al. 2017

Caries Res

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Objective: This study aimed to analyze the concentration and activity of carbonic anhydrase (CA) VI in the saliva of school children. We investigated the relationship among caries, CA VI concentration/activity, flow rate, pH, and buffering capacity. Materials and Methods: Seventy-four school children were divided into a caries-free group and a caries group. Clinical examinations were conducted by one examiner according to World Health Organization criteria + early caries lesions. Salivary flow rate, pH, and buffering capacity were analyzed. Salivary CA VI concentration and activity were evaluated by ELISA and zymography, respectively. The data were analyzed using Student's t test and the Mann-Whitney test, and Pearson and Spearman correlation analyses were also done. In multivariate modeling, associations between variables were expressed as odds ratios. Results: The results showed that salivary flow rate, salivary pH, and BC were significantly higher in the saliva of caries-free children. Also, the salivary CA VI concentration was significantly higher in the saliva of caries-free children. The salivary CA VI activity was higher in children with caries. We found a negative correlation between BC and dental caries. Also, in the caries group we found a positive correlation between the concentration and the activity of CA VI and a negative correlation between BC and CA VI activity. A negative correlation between salivary pH and CA VI concentration was observed in the caries-free group. A high activity of CA and a low salivary flow rate were associated with dental caries. Conclusion: These results support the conclusion that dental caries is highly affected by the activity of CA VI in saliva as well as by the salivary flow rate.

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Can insoluble polysaccharide concentration in dental plaque, sugar exposure and cariogenic microorganisms predict early childhood caries? A follow-up study

Cited by 26 publications

References 29 publications

Breastfeeding, Dental Biofilm Acidogenicity, and Early Childhood Caries

Breastfeeding, Dental Biofilm Acidogenicity, and Early Childhood Caries

A Longitudinal Study of Early Childhood Caries and Associated Factors in Brazilian Children

Children with a Higher Activity of Carbonic Anhydrase VI in Saliva Are More Likely to Develop Dental Caries

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