Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were performed before and on the 21 day treatment with robenacoxib (1), robenacoxib, herbal solution with liquorice extract (2), placebo -an empty capsule (3). There were 5 animals in each group. The greatest microscopic damage in the colon was observed in animals which received robenacoxib. Plant drug administration reduced the severity of lesions in the colon when administered with robenacoxib (ARI = -0.15). Conclusion: concurrent administration of liquorice extract and plant solution with robenacoxib was associated with significant decreased severity of the robenacoxib-induced colonic mucosal lesions.

Gastroprotectants in small animal veterinary practice – a review of the evidence. Part 1: cyto‐protective drugs

“…), two on LEHR (Szweda et al . , ) and one article each for a sucralfate‐like PEPPS—elm mucilage (McCullough ), irsogladine maleate (Sato et al . ), Seabuckthorn oil (Dogra et al .…”

“…Two similar experimental RCTs performed by the same authors compared the effect of LEHR, containing extracts of thyme, Icelandic lichen, hyssop, and saponariae root, in healthy Beagles receiving a 21‐day course of robenacoxib or carprofen (Szweda et al . , ). These studies focused on endoscopic and histological signs of colonic inflammation.…”

“…The cytoprotective effect of bismuth is not linked to acid production Not assessed Stables et al (1993) two on bismuth (Soldani et al 1985, Stables et al 1993, two on LEHR (Szweda et al 2014(Szweda et al , 2015 and one article each for a sucralfate-like PEPPS-elm mucilage (McCullough 2013), irsogladine maleate (Sato et al 2009), Seabuckthorn oil (Dogra et al 2013), smectite (Fioramonti & Droy-Lefaix 1987), and alginate (Shiraishi et al 1991). Of these, only one article evaluated response in cats (McCullough 2013), while all the others studied dogs.…”

“…Two similar experimental RCTs performed by the same authors compared the effect of LEHR, containing extracts of Quality group [a good quality (score 0 to 4), b moderate quality (score 5 to 8), c poor quality (score 9 to 12)] ¶ Quality score was 8/10 as one criterion could not be scored thyme, Icelandic lichen, hyssop, and saponariae root, in healthy Beagles receiving a 21-day course of robenacoxib or carprofen (Szweda et al 2014(Szweda et al , 2015. These studies focused on endoscopic and histological signs of colonic inflammation.…”