Can Liver Function Tests Be Used as an Early Marker to Assess the Severity of Dengue Fever? A Study of Prognostic Markers of Dengue Fever

Nawaz, Arif; Ahmed, Asim; Alvi, Aftab; Chaudhry, Asad; Butt, Ambreen

doi:10.14309/00000434-201110002-00315

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Liver Involvement As An Indicator Of Dengue Virus Infection Severity1

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2015

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“…Severe hepatitis, defined as an ALT level greater than 300 IU/L, was associated with prolonged length of hospital stay, mortality, bleeding, and renal failure. Nawaz and colleagues from Lahore, Pakistan evaluated the ability of liver chemistries to predict the severity of dengue infection [27].They found that AST levels were two fold greater than ALT levels. However, AST levels did not correlate with the development of complications or the duration of hospital stay.…”

Section: Liver Involvement As An Indicator Of Dengue Virus Infection Severitymentioning

confidence: 99%

Dengue and the Liver

Ahmed¹

2015

SM J Hepat Res Treat

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An estimated 50 million dengue infections occur annually across approximately 100 tropical and subtropical countries. There is extensive clinical, biochemical, histological, radiographic, and experimental evidence of liver involvement in dengue virus infections. Transaminase elevations are commonly seen. Most cases of dengueassociated liver disease are mild. Severe acute hepatitis due to the dengue virus is uncommon. Proposed causes of liver dysfunction in dengue virus infections include a direct viral effect on hepatocytes and a dysregulated host immune response against the virus. Several avenues of future research are suggested.

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Section: Liver Involvement As An Indicator Of Dengue Virus Infection Severitymentioning

confidence: 99%

Dengue and the Liver

Ahmed¹

2015

SM J Hepat Res Treat

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Can Liver Function Tests Be Used as an Early Marker to Assess the Severity of Dengue Fever? A Study of Prognostic Markers of Dengue Fever

Cited by 1 publication

References 0 publications

Dengue and the Liver

Dengue and the Liver

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