Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?

Abstract

AIMTo investigate serum mean platelet volume (MPV) levels in acute pancreatitis (AP) patients and assess whether MPV effectively predicts the disease severity of AP.METHODSWe included 117 consecutive patients with AP as the AP group and 34 consecutive patients with colorectal polyps (before endoscopic treatment) as the control group. Complete blood counts, liver function, platelet indices (MPV), coagulation parameters, lactate dehydrogenase (LDH) and C-reactive protein (CRP) were measured on days 1, 2, 3 and 7 after admission. Receiver operating characteristic curves were used to compare the sensitivity and specificity of MPV, white blood cell (WBC), LDH and CRP in predicting AP severity. The Modified Glasgow Prognostic Score (mGPS) and the 2012 revised Atlanta criteria were used to evaluate disease severity in AP.RESULTSMPV levels were significantly lower in the AP group than in the control group on day 1 (P = 0.000), day 2 (P = 0.029) and day 3 (P = 0.001) after admission. In addition, MPV values were lower on day 1 after admission than on day 2 (P = 0.012), day 3 (P = 0.000) and day 7 (P = 0.002) in all AP patients. Based on the mGPS, 78 patients (66.7%) were diagnosed with mild and 39 patients (33.3%) with severe AP. There was no significant difference in mean MPV levels between patients diagnosed with mild and severe AP based on the mGPS (P = 0.424). According to the 2012 revised Atlanta criteria, there were 98 patients (83.8%) without persistent organ failure (OF) [non-severe acute pancreatitis (non-SAP) group] and 19 patients (16.2%) with persistent OF (SAP group). MPV levels were significantly lower in the SAP group than in the non-SAP group on day 1 after admission (P = 0.002). On day 1 after admission using a cut-off value of 6.65 fL, the overall accuracy of MPV for predicting SAP according to the 2012 revised Atlanta criteria (AUC = 0.716) had a sensitivity of 91.8% and a specificity of 47.4% and was superior to the accuracy of the traditional markers WBC (AUC = 0.700) and LDH (AUC = 0.697).CONCLUSIONMPV can be used at no additional cost as a useful, non-invasive biomarker that distinguishes AP with persistent OF from AP without persistent OF on day 1 of hospital admission.

Artificial neural networks accurately predict intra‐abdominal infection in moderately severe and severe acute pancreatitis

“…Moreover, ANN model showed the top five important parameters with high normalized importance, including D‐dimer, MA, INR, IL‐6 and PT, indicating the amount and function of platelets were the common factor in both models. As there was no statistical difference in the amount of platelet counts between patients with and without intra‐abdominal infection, platelet functions, including their capacity of adhesion, aggregation, deformation and release, may be the predictive factors with greater relevance to intra‐abdominal infection, which coincides with the results of previous studies demonstrating that platelet function was altered during AP . An elevated MA indicated a hypercoagulation state in patients with intra‐abdominal infection, which is in accordance with the idea that enhanced platelet activation and a hypercoagulation state could be present in the late phase of SAP .…”

Role of mean platelet volume in hypertriglyceridemia-induced acute pancreatitis during pregnancy

“…Another contemporaneous study reported that MPV was signi cantly lower on admission than during remission in biliary and non-biliary AP patients [9]. Recently, Lei et al [22] also reported that MPV levels were signi cantly lower in the AP group than the control group, and MPV presented an upward trend during the rst week after admission in all AP patients.…”

“…Since the main purpose of this study was to distinguish SAP in the early stage of the disease, MSAP and MAP were merged with the Non SAP group, while AP with SAP was considered the SAP group. We de ned gestational age as the rst (before 12 weeks), second (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) weeks), and third trimesters (28 weeks until delivery).…”

Platelet indices as potential biomarkers for determining active ulcerative colitis and assessing the efficacy of biological treatment – experience of a single centre – a pilot study

“…MPV changes are not exclusively linked to IBD. They correlate with various systemic disorders such as myocardial infarction, rheumatoid arthritis and acute pancreatitis [7,8]. PDW and MPV were also reported to be potential prognostic markers in the course of colorectal cancer; elevated MPV was also found to indicate its poor prognosis.…”