Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis

Bao, Tingting; Zeng, Liuting; Yang, Kailin; Li, Yuehua; Ren, Fengying; Zhang, Yulong; Wang, Shouguo

doi:10.1155/2019/5151678

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…The daily oral melatonin administration (100 mg/kg body weight) has been reported to increase bone formation to prevent ovariectomy-induced bone degeneration in mice ( 57 ). Although its efficacy requires further confirmation, melatonin is considered a safe nutritional supplement for peri- and postmenopausal women to improve bone density ( 58 ). Moreover, a dietary melatonin supplement has been shown to improve the microstructure and biomechanical properties of the bones of aged rats ( 59 ).…”

Section: Osteoporosismentioning

confidence: 99%

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Chen

et al. 2021

Int J Mol Med

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Bone-related diseases comprise a large group of common diseases, including fractures, osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly the elderly. The progressive destruction and loss of alveolar bone caused by periodontitis is a specific type of bone loss, which has a high incidence and markedly reduces the quality of life of patients. With the existing methods of prevention and treatment, the incidence and mortality of bone-related diseases are still gradually increasing, creating a significant financial burden to societies worldwide. To prevent the occurrence of bone-related diseases, delay their progression or reverse the injuries they cause, new alternative or complementary treatments need to be developed. Melatonin exerts numerous physiological effects, including inducing anti-inflammatory and antioxidative functions, resetting circadian rhythms and promoting wound healing and tissue regeneration. Melatonin also participates in the health management of bone and cartilage. In the present review, the potential roles of melatonin in the pathogenesis and progression of bone injury, osteoporosis, OA and periodontitis are summarized. Furthermore, the high efficiency and diversity of the physiological regulatory effects of melatonin are highlighted and the potential benefits of the use of melatonin for the clinical prevention and treatment of bone-related diseases are discussed.

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Section: Osteoporosismentioning

confidence: 99%

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Chen

et al. 2021

Int J Mol Med

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“…Kotlarczyk et al [84] found that melatonin treatment decreased the bone resorption to bone formation ratio (NTX:OCN) in perimenopausal women, as measured by the serum levels of the respective markers [84]. Another study showed that treating perimenopausal and postmenopausal women with melatonin resulted in increased BMD and osteocalcin, an osteogenic marker [85]. Other studies have focused on the mechanisms through which melatonin may exert its bone-forming effects.…”

Section: The Use Of Melatonin As An Osteogenic Therapymentioning

confidence: 99%

The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging

Anaya

Bollag

Hamrick

et al. 2020

IJMS

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Although aging is considered a normal process, there are cellular and molecular changes that occur with aging that may be detrimental to health. Osteoporosis is one of the most common age-related degenerative diseases, and its progression correlates with aging and decreased capacity for stem cell differentiation and proliferation in both men and women. Tryptophan metabolism through the kynurenine pathway appears to be a key factor in promoting bone-aging phenotypes, promoting bone breakdown and interfering with stem cell function and osteogenesis; however, little data is available on the impact of tryptophan metabolites downstream of kynurenine. Here we review available data on the impact of these tryptophan breakdown products on the body in general and, when available, the existing evidence of their impact on bone. A number of tryptophan metabolites (e.g., 3-hydroxykynurenine (3HKYN), kynurenic acid (KYNA) and anthranilic acid (AA)) have a detrimental effect on bone, decreasing bone mineral density (BMD) and increasing fracture risk. Other metabolites (e.g., 3-hydroxyAA, xanthurenic acid (XA), picolinic acid (PIA), quinolinic acid (QA), and NAD+) promote an increase in bone mineral density and are associated with lower fracture risk. Furthermore, the effects of other tryptophan breakdown products (e.g., serotonin) are complex, with either anabolic or catabolic actions on bone depending on their source. The mechanisms involved in the cellular actions of these tryptophan metabolites on bone are not yet fully known and will require further research as they are potential therapeutic targets. The current review is meant as a brief overview of existing English language literature on tryptophan and its metabolites and their effects on stem cells and musculoskeletal systems. The search terms used for a Medline database search were: kynurenine, mesenchymal stem cells, bone loss, tryptophan metabolism, aging, and oxidative stress.

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“…It was found that melatonin increased BMD of femoral neck and lumbar spine in both perimenopausal and postmenopausal women. Combined treatment with melatonin improves scores at the femoral neck and lumbar spine, and melatonin may increase osteocalcin in both perimenopausal and postmenopausal women [27] . Due to its unique antioxidant, anti-in ammatory, and immunomodulatory functions, melatonin possesses great medical potential.…”

Section: Discussionmentioning

confidence: 98%

Sema4d regulates the bone metabolism in combination with leptin or melatonin

Lin

Xiong

Lin

et al. 2022

Preprint

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Purpose The present study aims to explore the regulatory function of Sema4D on bone metabolism in combination with leptin or melatonin, as well as the underlying mechanism. Methods The osteoporosis model was established in rats using the OVX method. The bilateral tibial specimens of rats were taken for Micro-CT scanning analysis and three-dimensional reconstruction. The pathological state of bone tissues was evaluated by the HE staining assay. The concentration of estradiol in the serum was detected by the ELISA assay. Six groups were divided in the present study: Control, OVX, OVX + NL, OVX + Sema4D, OVX + Sema4D + leptin, and OVX + Sema4D + MT groups. According to the above grouping, the Sema4D or leptin overexpressing vectors were injected into rats through the tail vein. 3D bone structure was detected by high-resolution micro-CT system. Serum bone-derived alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase-5b (TRAP-5b) activities were measured by ELISA. TRAP staining was used to calculate the number of osteoclasts in the metaphysis of the upper tibia. The expressions of bone morphogenetic protein-2 (BMP-2) and leptin in bone tissue were detected by immunohistochemistry. Results Compared to OVX + NL, the level of V/TV, Tb.N, BMD, and BMC in the OVX + Sema4D + leptin and OVX + Sema4D + MT groups was extremely elevated, accompanied by a declined Tb.Sp level. Compared to the OVX group, in the OVX + Sema4D + leptin and OVX + Sema4D + MT groups, the structure of bone trabeculae was relatively complete and tended to be closely arranged. The number of bone trabeculae was greatly increased and the number of TRAP-positive osteoclasts decreased significantly, accompanied by an upregulation of BMP-2 and leptin, and a declined activity of BALP and TRAP-5b. Conclusion The function of Sema4d on the microstructure of trabecular bone, bone formation, and repairment on the trabecular bone damage in osteoporosis rats was improved by leptin or melatonin.

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Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis

Cited by 8 publications

References 32 publications

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging

Sema4d regulates the bone metabolism in combination with leptin or melatonin

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