Can melatonin regulate the expression of prohormone convertase 1 and 2 genes via monomeric and dimeric forms of RZR/ROR nuclear receptor, and can melatonin influence the processes of embryogenesis or carcinogenesis by disturbing the proportion of cAMP and cGMP concentrations? Theoretic model of controlled apoptosis

Ciesla, W.

doi:10.1054/mehy.2000.1137

Cited by 7 publications

(3 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also has helped to explain how living organisms can function as integrated mechanical systems, even though they are complex hierarchical structures (molecules within cells within tissues within organs). Indeed, the tensegrity principle has been invoked by investigators to explain an unusually wide range of unexplained phenomena in many different systems and species, including: lipid micelle formation (Butcher and Lamb, 1984), protein folding in milk globules (Farrell et al, 2002), protein organization within viral capsids (Caspar, 1980), the structure of actin microfilaments (Schutt et al, 1997), pattern formation in paramecium (Kaczanowska et al, 1995), hyphal morphology in fungi (Kaminsky and Heath, 1996), neurite outgrowth (Joshi et al, 1985;Buxbaum and Heidemann, 1988), endothelial permeability barrier function (Moy et al, 1998), vascular tone (Northover and Northover, 1993), dystrophin function in muscular dystrophy (Gillis, 1999), choriocarcinoma differentiation (Hohn et al, 1996), control of apoptosis (Ciesla, 2001), morphogenesis of mammalian cells and tissues (Ingber et al, 1981;Ingber and Jamieson, 1985;Pienta and Coffey, 1991a;Pienta et al, 1991;Huang and Ingber, 1999;Ingber et al, 1994), the structure of the skin (Ryan, 1989), lens (Yamada et al, 2000), cartilage (Malinin and Malinin, 1999), retina (Galli-Resta, 2002) and brain (Van Essen, 1997), the mechanics of the human skeleton (Levin, 1997), tumor formation and metastasis (Ingber et al, 1981;Ingber and Jamieson, 1985;Pienta and Coffey, 1991b;Huang and Ingber, 1999), as well as gravity sensing in both animals and plants Yoder e...…”

Section: Resultsmentioning

confidence: 99%

Tensegrity I. Cell structure and hierarchical systems biology

Ingber

2003

Journal of Cell Science

1,124

795

View full text Add to dashboard Cite

In 1993, a Commentary in this journal described how a simple mechanical model of cell structure based on tensegrity architecture can help to explain how cell shape, movement and cytoskeletal mechanics are controlled, as well as how cells sense and respond to mechanical forces (J. Cell Sci.104, 613-627). The cellular tensegrity model can now be revisited and placed in context of new advances in our understanding of cell structure,biological networks and mechanoregulation that have been made over the past decade. Recent work provides strong evidence to support the use of tensegrity by cells, and mathematical formulations of the model predict many aspects of cell behavior. In addition, development of the tensegrity theory and its translation into mathematical terms are beginning to allow us to define the relationship between mechanics and biochemistry at the molecular level and to attack the larger problem of biological complexity. Part I of this two-part article covers the evidence for cellular tensegrity at the molecular level and describes how this building system may provide a structural basis for the hierarchical organization of living systems — from molecule to organism. Part II, which focuses on how these structural networks influence information processing networks, appears in the next issue.

show abstract

Section: Resultsmentioning

confidence: 99%

Tensegrity I. Cell structure and hierarchical systems biology

Ingber

2003

Journal of Cell Science

1,124

795

View full text Add to dashboard Cite

show abstract

“…They can silence proteins' expression through complementary binding with the encoding proteins' mRNAs, as a result of which, they can regulate cell growth, differentiation, proliferation, apoptosis or metabolism . The occurrence and development of tumors are the results of uncontrolled cell proliferation and apoptosis . Therefore, the relationship between miRNAs and tumors is becoming a hotspot of current research .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

Huang

Yang

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

MicroRNA-26a-5p (miR-26a-5p) has been reported to be involved in the tumorigenesis of several tumors, but its function in breast cancer is still unknown. In this study, miR-26a-5p was found significantly downregulated in both of the breast cancer tissues and cell lines, and low expression of miR-26a-5p predicted a poor prognosis for breast cancer patients. Overexpression of miR-26a-5p could significantly inhibit breast cancer cell growth. Further studies revealed that overexpression of miR-26a-5p downregulated the protein levels of Cyclin D1, CDK4, and CDK6, but upregulated the expression levels of p21, p27, and p53. In mechanism, miR-26a-5p targeted the 3 0 UTR of ring finger protein 6 (RNF6) mRNA and inhibited RNF6 expression in breast cancer cells.Moreover, overexpression of miR-26a-5p inhibited RNF6/ERα/Bcl-xL axis in breast cancer cells. In contrast, inhibiting miR-26a-5p upregulated RNF6/ERα/Bcl-xL axis.Further studies indicated that miR-26a-5p mediated RNF6/ERα/Bcl-xL axis through regulating the stability of ERα protein. Collectively, downregulation of miR-26a-5p plays essential roles in breast cancer by mediating RNF6/ERα/Bcl-xL axis, which might provide important implications for the therapeutics of breast cancer.

show abstract

“…A pregnant mother's secretion of melatonin can affect fetal brain development in diverse ways. This molecule binds to receptors in many sites, including the hypothalamus, contributes to cell death, and suppresses both dopamine release and cortisol production (Ciesla, 2001;TorresFarton et al, 2004;Zisapel, 2001).…”

Section: Temperaments As Sets Of Preparedness Jerome Kaganmentioning

confidence: 99%

Temperaments as Sets of Preparedness

Kagan

2010

Nurturing Children and Families

View full text Add to dashboard Cite

Each generation contains a small number of prescient minds that refuse to accept the popular and often simplistic conceptualizations that dominate their discipline and insist on accommodating to what they have observed. Berry Brazelton is a special member of this rare category. When developmental psychologists denied that infants possessed any biologically based biases for emotional or behavioral reactions, Brazelton's rich experience with infants led him to suggest that each infant brought into the world a set of dispositions that prepared her or him to develop, with ease or difficulty, particular personality profiles. But he insisted that the profiles that emerged over the years depended on the family and other environmental settings. These social contexts selected from a potential envelope of many profiles inherent in the infants' temperamental biases a most likely pattern of traits. The initial biases do not determine a particular psychological profile in later childhood; they only limit the range of profiles that might occur. Psychologists, pediatricians, and psychiatrists who resisted this idea initially have recently become more receptive to its validity.The reintroduction of the idea of temperamental biases a half century after their exile by behaviorists and psychoanalysts is one of the most important scientific advances of the past four decades. Although we are still far from being able to describe all the human temperaments, and have not invented the procedures to quantify them, scientists have begun this task. My colleagues and I have been studying only two of the large number of possible temperaments and this paper summarizes what we have learned over the past 30 years.

show abstract

Cited by 7 publications

References 132 publications

Tensegrity I. Cell structure and hierarchical systems biology

Tensegrity I. Cell structure and hierarchical systems biology

MicroRNA‐26a‐5p inhibits breast cancer cell growth by suppressing RNF6 expression

Temperaments as Sets of Preparedness

Contact Info

Product

Resources

About