Can mothers be trusted to give malaria treatment to their children at home?

Kofoed, Poul‐Erik; López, Francisco Escribano; Aaby, Péter; Hedegaard, Kathryn; Rombo, Lars

doi:10.1016/s0001-706x(03)00018-4

Cited by 12 publications

(15 citation statements)

References 206 publications

(296 reference statements)

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“…(2004) found that blood chloroquine levels in children whose carer reported full adherence to a 25 mg/kg dose taken unsupervised at home were not significantly different from levels in children who had received 25 mg/kg under supervision. A similar finding, suggesting that carers’ reports of adherence were reliable, was reported by Kofoed et al. (2003) who found that the median day 7 chloroquine levels in children whose mothers had retained empty medicine bags did not differ significantly from those who had thrown them away (546 nmol/l vs. 644 nmol/l, respectively, P > 0.05).…”

Section: Drug Assayssupporting

confidence: 77%

How do patients use antimalarial drugs? A review of the evidence

Yeung

White

2005

Tropical Med Int Health

116

129

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SummaryPatient adherence is a major determinant of the therapeutic response to antimalarial drugs, as most treatments are taken at home without medical supervision. With the introduction of new, effective, but more expensive antimalarials, there is concern that the high levels of efficacy observed in clinical trials may not be translated into effectiveness in the normal context of use. We reviewed available published evidence on adherence to antimalarial drugs and community drug usage; 24 studies were identified of which nine were 'intervention' studies, seven were classified as 'outcome studies', and the remainder were purely descriptive studies of antimalarial adherence. Definitions, methods, and results varied widely. Adherence was generally better when treatments were effective, and was improved by interventions focusing on provider knowledge and behaviour, packaging, and provision of correct dosages. There is insufficient information on this important subject, and current data certainly do not justify extrapolation from results with ineffective drugs to new effective treatments. Research in this area would benefit from of standardization of methodologies and the application of pharmacokinetic modelling.

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Section: Drug Assayssupporting

confidence: 77%

How do patients use antimalarial drugs? A review of the evidence

Yeung

White

2005

Tropical Med Int Health

116

129

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“…25 Interestingly, there was no significant difference in treatment outcome, leading the investigators to conclude that mothers in this part of Guinea Bissau could "be trusted to give adequate anti-malarial medication to their children at home." 25 The remaining three composite indicator studies targeted both providers and users. All three involved public providers, one formal sector 21 and two community-based.…”

Section: Resultsmentioning

confidence: 99%

Review: Provider Practice and User Behavior Interventions to Improve Prompt and Effective Treatment of Malaria: Do We Know What Works?

Smith

Jones²,

Meek³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Effective case management of uncomplicated malaria is a cornerstone of successful malaria control. With current calls for the global elimination of malaria, all strategies to control malaria need to reach the highest achievable level of effective implementation. A systematic literature review of all interventions to improve provider-and/or userside behavior in the prompt and appropriate treatment of uncomplicated malaria (with appropriate evaluation design and Roll Back Malaria outcome indicators) found 23 studies for review. Only 16 studies targeted providers, nine in the public sector and seven in the private sector. Just four interventions were conducted at national scale. These data suggest that very little is known about what interventions work in improving prompt and effective treatment of malaria. In the context of scaling up effective malaria control and malaria elimination plans and in increasing access to artemisinin combination therapies (ACTs), increased research in this area is crucial.

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“…Future studies may build upon this strength by considering the following limitations. First, incorporating data on previously identified influences on TSB, including direct financial factors such as treatment costs, user fees and household income [62-67], indirect costs of seeking treatment such as loss of income and time [1,62,67], urban or rural dwelling [15,63,67]; household size and the effects of overcrowding, [1,63,65,66]; caregiver characteristics such as literacy [63,15], previous treatment-seeking experiences, educational status and the severity of illness [67] will substantially add to the findings from this study.…”

Section: Discussionmentioning

confidence: 99%

“…In many cases, for example, traditional remedies are used in conjunction with biomedical treatments for malaria treatment [20] suggesting that illness may simultaneously be perceived in a variety of different ways. Therefore, choices of treatment are dependent not just on the strength of local traditions [23], but also on the person's knowledge of biomedical malaria treatments [24]. …”

Section: Introductionmentioning

confidence: 99%

Seeking treatment for symptomatic malaria in Papua New Guinea

Davy

Ome

Lawrence‐Wood

et al. 2010

Malar J

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BackgroundMalaria places a significant burden on the limited resources of many low income countries. Knowing more about why and where people seek treatment will enable policy makers to better allocate the limited resources. This study aims to better understand what influences treatment-seeking behaviour for malaria in one such low-income country context, Papua New Guinea (PNG).MethodsTwo culturally, linguistically and demographically different regions in PNG were selected as study sites. A cross sectional household survey was undertaken in both sites resulting in the collection of data on 928 individuals who reported suffering from malaria in the previous four weeks. A probit model was then used to identify the factors determining whether or not people sought treatment for presumptive malaria. Multinomial logit models also assisted in identifying the factors that determined where people sought treatments.ResultsResults in this study build upon findings from other studies. For example, while distance in PNG has previously been seen as the primary factor in influencing whether any sort of treatment will be sought, in this study cultural influences and whether it was the first, second or even third treatment for a particular episode of malaria were also important. In addition, although formal health care facilities were the most popular treatment sources, it was also found that traditional healers were a common choice. In turn, the reasons why participants chose a particular type of treatment differed according to the whether they were seeking an initial or subsequent treatments.ConclusionsSimply bringing health services closer to where people live may not always result in a greater use of formal health care facilities. Policy makers in PNG need to consider within-country variation in treatment-seeking behaviour, the important role of traditional healers and also ensure that the community fully understands the potential implications of not seeking treatment for illnesses such as malaria at a formal health care facility.

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Can mothers be trusted to give malaria treatment to their children at home?

Cited by 12 publications

References 206 publications

How do patients use antimalarial drugs? A review of the evidence

How do patients use antimalarial drugs? A review of the evidence

Review: Provider Practice and User Behavior Interventions to Improve Prompt and Effective Treatment of Malaria: Do We Know What Works?

Seeking treatment for symptomatic malaria in Papua New Guinea

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