Can mRNA COVID‐19 vaccines induce flares of chronic urticaria?

Kanokrungsee, Silada; Naruenatwanich, Chananchida

doi:10.1111/jocd.15443

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…The authors also observed that fewer exacerbations happened when patients were under omalizumab therapy [ 124 , 127 ]. Likewise, Lascialfari et al [ 125 , 128 ] reported that relapse or exacerbation of urticaria after SARS-CoV-2 vaccination was observed in only 7.7% of pediatric CSU patients which lasted for less than one week. Picone et al [ 126 , 129 ] reported postvaccine urticaria to flare up in 8% of CSU patients who were well controlled under antihistamine and omalizumab treatment, while Tuchinda et al [ 127 , 130 ] reported a higher rate (15%).…”

Section: Vaccines and Urticariamentioning

confidence: 99%

“…Picone et al [ 126 , 129 ] reported postvaccine urticaria to flare up in 8% of CSU patients who were well controlled under antihistamine and omalizumab treatment, while Tuchinda et al [ 127 , 130 ] reported a higher rate (15%). Others found no effect of mRNA-SARS-CoV-2 vaccination on urticaria activity scores in 28 patients with CSU [ 128 , 131 ].…”

Section: Vaccines and Urticariamentioning

confidence: 99%

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How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

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Since more than a century ago, there has been awareness of the connection between viral infections and the onset and exacerbation of urticaria. Our knowledge about the role of viral infection and vaccination in acute and chronic urticaria improved as a result of the COVID-19 pandemic but it has also highlighted knowledge gaps. Viral infections, especially respiratory tract infections like COVID-19, can trigger the onset of acute urticaria (AU) and the exacerbation of chronic urticaria (CU). Less frequently, vaccination against viruses including SARS-CoV-2 can also lead to new onset urticaria as well as worsening of CU in minority. Here, with a particular focus on COVID-19, we review what is known about the role of viral infections and vaccinations as triggers and causes of acute and chronic urticaria. We also discuss possible mechanistic pathways and outline the unmet needs in our knowledge. Although the underlying mechanisms are not clearly understood, it is believed that viral signals, medications, and stress can activate skin mast cells (MCs). Further studies are needed to fully understand the relevance of viral infections and vaccinations in acute and chronic urticaria and to better clarify causal pathways.

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Section: Vaccines and Urticariamentioning

confidence: 99%

Section: Vaccines and Urticariamentioning

confidence: 99%

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Of note, the mean duration of urticaria following vaccination was 22 hours [4]. Reports of CSU have followed mRNA (Moderna mRNA-1273, BNT162b2), viral vector (AstraZeneca/Oxford ChAdOx1-S/nCoV-19), and inactivated viral (Sinovac-Coronovac) vaccine types (Table 1), [5,[9][10][11][12][13][14][15][16][17][18][19]. However, new-onset CSU following heterologous mRNA vaccination has yet to be evaluated specifically.…”

Section: Case Discussionmentioning

confidence: 99%

“…Vaccination has caused exacerbation, with some cases resolving in less than a day [16,20] and others requiring management beyond the patient's standard therapy [9,12]. On the other hand, some reports note no significant change in CSU course after vaccination [14,19]. In their cohort of 91 patients, Purayil et al found most patients (70.3%) with chronic urticaria did not experience worsening of symptoms after vaccination [14].…”

Section: Case Discussionmentioning

confidence: 99%

Refractory chronic spontaneous urticaria after heterologous COVID-19 booster vaccination

Tomaras,

Douglas,

Schmidt

et al. 2024

DOJ

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“…Fever, fatigue, and headache are also commonly reported systemic reactions (3)(4)(5). The relationship between CSU and vaccines is reported in the literature (6), however, some publications have given different results about the effects of COVID-19 vaccines on patients with CSU (7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers

Kartal,

Orujova,

Ertaş

2023

Front. Med.

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BackgroundThe relationship between CSU and vaccines is reported in the literature. The post-vaccine clinical effect of COVİD-19 vaccines on CSU patients is still unclear. we aimed to evaluate clinical effects of COVID-19 Vaccines on CSU patients.Materials and methodsCSU patients under treatment and follow-up in our outpatient clinic were evaluated retrospectively. To determine disease activity the urticaria activity score over seven days (UAS7) was used. The details of demographic information, CSU treatment, history of COVID-19 infection and exacerbation of urticaria during infection, COVID-19 vaccinations, type of vaccine, side effect reaction time after vaccination, hospital admission requirement were also assessed.ResultsTotal of 190 patients with a mean age of The mean age of patients was 41,7±14,0 years (range = 18–72) were enrooled. The patient sample consisted of 50 males and 140 females (male/female ratio 1:2.8). 181 (CoronaVac 77, Pfizer-BioNTech 104) patients were vaccinated. Urticarial exacerbation was occurred in 25 patients. The median UAS value was 5 before vaccination, it was 12 in patients with post-vaccine urticaria. Two patients had angioedema and one patient had anaphylaxis after vaccinated with Pfizer-BioNTech.ConclusionCOVID-19 vaccination in the CSU can be considered safe. Cases with urticarial exacerbation appear to be transient and can be managed by antihistamine and/or systemic steroid therapies. More extensive studies are needed for the relationship with CSU and post-coronavirus vaccination anaphylaxy.

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Can mRNA COVID‐19 vaccines induce flares of chronic urticaria?

Cited by 4 publications

References 5 publications

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Refractory chronic spontaneous urticaria after heterologous COVID-19 booster vaccination

Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers

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