Can Natural Products be Used to Overcome the Limitations of Colorectal Cancer Immunotherapy?

Dong, Jiahuan; Qian, Yufan; Zhang, Guangtao; Lu, Lu; Zhang, Shengan; Ji, Guang; Zhao, Aizhi; Xu, Hanchen

doi:10.3389/fonc.2022.884423

Cited by 4 publications

(8 citation statements)

References 101 publications

(93 reference statements)

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“…In addition, combined treatment strategy of natural products with immunosuppressive agents has been shown to be more effective in halting lung cancer than monotherapy in trials of natural anticancer products for lung cancer tumor microenvironment ( 109 ). Colon cancer (CRC) clinic research has found that natural products may affect the NK cells, T cells and Tregs of CRC to perform immunomodulatory functions for anti-tumor ( 110 ). Natural products have been shown to restore immune-suppressed tumor microenvironments under a single target and organ-specific inflammatory strategy, recruiting subpopulations of immune cells to perform their functions in the microenvironment ( 111 ).…”

Section: Natural Products Possess Anti-tumor Functionmentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

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With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand to find safer and more effective anticancer strategy for cancer patients. Natural products, have the advantage of low toxicity and multiple action targets, are always used in the treatment of cancer prevention in early stage and cancer supplement in late stage. Tumor microenvironment is necessary for cancer cells to survive and progression, and immune activation is a vital means for the tumor microenvironment to eliminate cancer cells. A number of studies have found that various natural products could target and regulate immune cells such as T cells, macrophages, mast cells as well as inflammatory cytokines in the tumor microenvironment. Natural products tuning the tumor microenvironment via various mechanisms to activate the immune response have immeasurable potential for cancer immunotherapy. In this review, it highlights the research findings related to natural products regulating immune responses against cancer, especially reveals the possibility of utilizing natural products to remodel the tumor microenvironment to overcome drug resistance.

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Section: Natural Products Possess Anti-tumor Functionmentioning

confidence: 99%

Remodeling tumor microenvironment with natural products to overcome drug resistance

Zhang

et al. 2022

Front. Immunol.

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“…Tumor cells avoid immune surveillance by suppressing the body’s immune system in various ways, thus enabling tumor immune escape. To counteract this, combinations of immuno- and chemotherapies are being developed to strengthen immune system response to tumors and to minimize the negative effects of chemotherapy ( 4 , 5 ).…”

Section: Bc Treatmentmentioning

confidence: 99%

“…Other cells with a role in immune regulation are CD4+ effector T cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), DCs, NKs, and mast cells ( 11 ). Several immunosuppressive factors, such as prostaglandin E2 (PGE2), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β), are secreted by these cells to regulate the immunosuppressive network ( 5 ).…”

Section: Tumor Immune Microenvironment and Breast Cancermentioning

confidence: 99%

“…The development of the M2-like TAM macrophage is encouraged by the existence of IL-4 and IL-13 in the TME. Tumor cells can produce macrophage-derived chemokines such as C–C motif chemokine 22, which then bring monocytes into the tumors; if immuno-suppressive conditions prevail, these monocytes will then differentiate into TAMs ( 5 ). Immune cells called neutrophils also have the potential to promote or hinder tumor development.…”

Section: Tumor Immune Microenvironment and Breast Cancermentioning

confidence: 99%

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Natural products as promising modulators of breast cancer immunotherapy

Alqathama

2024

Front. Immunol.

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Breast cancer (BC) is the most common malignancy among women and is considered a major global health challenge worldwide due to its high incidence and mortality rates. Treatment strategies for BC is wide-ranging and include surgery, radiotherapy, chemotherapy, targeted hormonal therapy and immunotherapy. Immunotherapy has gained popularity recently and is often integrated as a component of personalized cancer care because it aims to strengthen the immune system and enable it to recognize and eradicate transformed cells. It has fewer side-effects and lower toxicity than other treatment strategies, such as chemotherapy. Many natural products are being investigated for a wide range of therapeutic pharmacological properties, such as immune system modulation and activity against infection, auto-immune disease, and cancer. This review presents an overview of the major immune response-related pathways in BC, followed by detailed explanation of how natural compounds can act as immunomodulatory agents against biomolecular targets. Research has been carried out on many forms of natural products, including extracts, isolated entities, synthetic derivatives, nanoparticles, and combinations of natural compounds. Findings have shown significant regulatory effects on immune cells and immune cytokines that lead to immunogenic cancer cell death, as well as upregulation of macrophages and CD+8 T cells, and increased natural killer cell and dendritic cell activity. Natural products have also been found to inhibit some immuno-suppressive cells such as Treg and myeloid-derived suppressor cells, and to decrease immunosuppressive factors such as TGF-β and IL-10. Also, some natural compounds have been found to target and hinder immune checkpoints such as PD-L1.

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“…A herbal extract may have several organic chemicals ( Zhang et al, 2012 ), and the efficacy can result from the synergistic effects of constituents ( Ahmad et al, 2006 ). The paucity of clinical trials ( Rivera et al, 2013 ) and lack of dose standardization are the other limiting issues ( Dong et al, 2022 ). However, the use of herbal medicine is increasing worldwide, and its benefits cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%