Can Nonpenetrating Vascular Closure Staples and Hepatocyte Growth Factor Prevent Intimal Hyperplasia Following ePTFE Grafting of the Carotid Artery in Rabbits?

Abstract

The VCS clip failed to suppress intimal thickness or reduce the percentage of stenosis at the anastomotic site.

Randomized clinical trial of continuous sutures or non-penetrating clips for radiocephalic arteriovenous fistula

“…In a number of experimental studies the degree of intimal hyperplasia with clips was similar to, or less than, that associated with sutures14–18. In contrast, one group noted increased intimal hyperplasia with clips19.…”

Sutureless anastomotic devices for vascular surgery

“…However, with four anastomoses, this was a small group and there were no sutured controls. Akita [17] experienced patency rates down to 43% for clipped 2-mm polytetrafluoroethylene (PTFE) grafts compared with 100% for sutured controls.…”