Can novel methods replace the gold standard chimerism method after allogeneic hematopoietic stem cell transplantation?

Sel, Figen Abatay; Oğuz, Fatma Savran

doi:10.1007/s00277-023-05448-3

Ann Hematol

2023

DOI: 10.1007/s00277-023-05448-3

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Can novel methods replace the gold standard chimerism method after allogeneic hematopoietic stem cell transplantation?

Figen Abatay Sel,

Fatma Savran Oğuz

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2024

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Cited by 1 publication

References 70 publications

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Droplet digital PCR: An effective method for monitoring and prognostic evaluation of minimal residual disease in JMML

Mao,

Lin,

Qin

et al. 2024

Br J Haematol

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SummaryJuvenile myelomonocytic leukaemia (JMML) is a rare myeloproliferative neoplasm requiring haematopoietic stem cell transplantation (HSCT) for potential cure. Relapse poses a significant obstacle to JMML HSCT treatment, as the lack of effective minimal residual disease (MRD)‐monitoring methods leads to delayed interventions. This retrospective study utilized the droplet digital PCR (ddPCR) technique, a highly sensitive nucleic acid detection and quantification technique, to monitor MRD in 32 JMML patients. The results demonstrated that ddPCR detected relapse manifestations earlier than traditional methods and uncovered molecular insights into JMML MRD dynamics. The findings emphasized a critical 1‐ to 3‐month window post‐HSCT for detecting molecular relapse, with 66.7% (8/12) of relapses occurring within this period. Slow MRD clearance post‐HSCT was observed, as 65% (13/20) of non‐relapse patients took over 6 months to achieve ddPCR‐MRD negativity. Furthermore, bone marrow ddPCR‐MRD levels at 1‐month post‐HSCT proved to be prognostically significant. Relapsed patients exhibited significantly elevated ddPCR‐MRD levels at this time point (p = 0.026), with a cut‐off of 0.465% effectively stratifying overall survival (p = 0.007), event‐free survival (p = 0.035) and cumulative incidence of relapse (p = 0.035). In conclusion, this study underscored ddPCR's superiority in JMML MRD monitoring post‐HSCT. It provided valuable insights into JMML MRD dynamics, offering guidance for the effective management of JMML.

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Droplet digital PCR: An effective method for monitoring and prognostic evaluation of minimal residual disease in JMML

Mao,

Lin,

Qin

et al. 2024

Br J Haematol

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Can novel methods replace the gold standard chimerism method after allogeneic hematopoietic stem cell transplantation?

Cited by 1 publication

References 70 publications

Droplet digital PCR: An effective method for monitoring and prognostic evaluation of minimal residual disease in JMML

Droplet digital PCR: An effective method for monitoring and prognostic evaluation of minimal residual disease in JMML

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