Can nutrition influence circadian rhythm and heart rate variability?

Singh, Ram B.; Weydahl, Andi; Otsuka, Kuniaki; Watanabe, Yoshihiko; Yano, S.; Mori, H; Ichimaru, Yuhei; Mitsutake, G.; Sato, Yuko; Lu, Fanghong; Zhao, Zhangwu; Kartik, C.; Gvozdjáková, Anna

doi:10.1016/s0753-3322(01)90016-2

Cited by 19 publications

(36 citation statements)

References 82 publications

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“…Thus there are at least two synchronised systems, the circadian system (for nutrition q.v. Singh [46][47][48] and the cell-cycle one coupled to the other by putatively serial or direct coupling [49].…”

Section: Chronobiologymentioning

confidence: 99%

Role of Hormones and Neuropeptides in IBS and other Gastrointestinal Disorders: Understanding Variability and Chrononutrition

et al. 2011

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Mind-brain-body-gene framework, including the role of chrononutrition, is probably implicated in the genesis of functional gastrointestinal diseases (FGIDs). Emphasis was placed on psychosocial dysregulation, the bridging of the Cartesian Gap, and chronobiology viz. the way circadian and other rhythmic structures of the brain, e.g. suprachiasmatic nucleus, and gastrointestinal tract interact partially explaining the phrase "we are what and when we eat". Chronobiological concepts of strain and stress in the context of sensory pain and the time-qualified network of gut hormones and neuropeptides are discussed for melatonin, serotonin, ghrelin, leptin, vasoactive intestinal peptide, neuropeptide Y, orexins, and others. The Tsimtsoum evolutionary aspects of diet from Palaeolithic to modern man in the context of increased omega-3/omega-6 fatty acid ratio reduces proinflammatory responses, important in pre-metabolic syndrome and cardiovascular disease, and protects against neuropsychic disorders possibly (FGIDs). Gut micro-organisms either affect the lumen (food substrates) and mucosa, where they reflect immunological, metabolic and physiologic function and importance of these two ecosystems. The interaction between enteric and autonomic systems and associated regulatory effects on proliferative and secretary epithelial dynamics and optimization of permeability for food nutrients and possible modulation of inflammation is an active area of research. In summary, this paper has focussed on the need to understand the multifarious aspects of biological and environmental variability, principally hormones and neuropeptides, in the possible genesis of (FGIDs).

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Section: Chronobiologymentioning

confidence: 99%

Role of Hormones and Neuropeptides in IBS and other Gastrointestinal Disorders: Understanding Variability and Chrononutrition

et al. 2011

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“…Homo sapiens and Homo erectus were not storing any food to eat in the morning and in the night, because they were hunting in the morning, and possibly ate heavy lunches. Therefore, increased consumption of energy as breakfast or as dinner may disrupt the functioning of the endogenous master clock [1][2][3][4][5][6][7][8][9][10][11][12][13]. It is possible that certain external activities, known as triggers, play a major role in the occurrence of these attacks.…”

Section: The Evolution Of Triggersmentioning

confidence: 99%

“…Emotional stress, sleep deprivation, large meals, mild and heavy physical exertion were the most frequently reported triggering factors of ACS, in association with marked reduction in antioxidant vitamins A, E , C, betacarotene, coenzyme Q10, magnesium, potassium, as well as increase in oxidative stress and proinflammatory cytokines, in various studies [1][2][3][4][5][6][7][11][12][13]. A large breakfast or dinner may also disturb the endogenous clock, responsible for conservation of energy, during the 2 nd and 3 rd quarters of the 24-hour cycle, causing obesity.…”

Section: The Evolution Of Triggersmentioning

confidence: 99%

“…Studies conducted by various investigators [2][3][4][5][6][7][11][12][13], have demonstrated a marked increase in sympathetic activity, oxidative stress and decrease in parasympathetic activity in association with increase in catecholamines, cortosol, and decrease in melatonin [1] (Table 1). In one case control study [5], involving 202 patients with ACS, brain related and psychological mechanisms were identified as emotional stress (45.5%), sleep deprivation (27.7%), cold climate (29.2%), hot climate (24.7%), large meals (47.5%) and physical exertion (31.2%).…”

Section: The Triggers and The Circadian Rhythm Of Cardiac Eventsmentioning

confidence: 99%

“…IL-18 is one of the most determining factor of rupture of atheroscle- rotic plaques along with metalloproteinases and metalloproteases. The ACS is also accompanied by a deficiency in the serum levels of vitamin A, E, C, coenzyme Q, magnesium, potassium, melatonin, interleukin-10 (anti-inflammatory) [4,5,12,13]. In our studies [4,5,7], we found a decrease in magnesium, potassium, vitamin A, E, C, beta-carotene and increase in TBARS, MDA, diene-conjugates, TNF-alpha and IL-6, which are indictors of oxidative damage and proinflammatory reactions, respectively.…”

Section: Biochemical Mechanismsmentioning

confidence: 99%

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Potential Chonobiological Triggering Factors of Acute Heart Attack

Sergey¹,

Rapoport²,

Агарвал³

et al. 2010

TONUTRAJ

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Abstract:The immediate triggers of acute heart attack or acute coronary syndrome (ACS) are not known exactly. There is a marked increase in sympathetic activity, neuroendocrino-logical dysfunction, oxidative stress and deficiency of 3 fatty acids, vitamins, minerals, as well as antioxidants during ACS. Energy intake and expenditure have diurnal variation throughout 24-hour cycle and any disturbance in this cycle may result into disruption of the endogenous clock and neurohumoral dysfunctions. Clinical studies have reported an increased incidence of reinfarction, sudden death, coronary constriction, myocardial ischaemia, vascular variability disorders and angina, during second quarter of the 24 hour cycle, at the point where there is rapid withdrawal of vagal activity and increase in sympathetic tone. In several studies, among patients with heart attack, there was a significant 2-3 fold increase in cardiac events in the second quarter of the day (6-12 hours) compared to other quarters respectively. Triggers of heart attack were noted in up to 80.0% of patients in various studies. Brain related and psychological mechanisms, i.e., emotional stress, sleep deprivation, cold climate, hot climate, large meals and physical exertion were observed among 30-50% of patients. Such triggers have also been reported in Europe, North America and Asia. These triggering factors are known to enhance sympathetic activity and decrease vagal tone, resulting into increased secretion of plasma cortisol, noradrenaline, aldosterone, angiotensin converting enzyme, interleukin-1, 2, 6, 18 and tumor necrosis factor-alpha, that are proinflammatory. There is also a deficiency in the serum levels of 3 fatty acids, vitamin A, E, C, coenzyme Q10, magnesium, potassium, melatonin, interleukin-10 (antiinflammatory) and increase in TBARS, MDA, diene conjugates, TNF-alpha and IL-6, which are indicators of oxidative damage and inflammation, respectively. It is not clear whether the predisposition of ACS is due to size of the meals or other proinflammatory factors of meals.

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The impact of heart rate circadian rhythm on in-hospital mortality in patients with stroke and critically ill: Insights from the eICU Collaborative Research Database

Yang

et al. 2022

Heart Rhythm

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Can nutrition influence circadian rhythm and heart rate variability?

Cited by 19 publications

References 82 publications

Role of Hormones and Neuropeptides in IBS and other Gastrointestinal Disorders: Understanding Variability and Chrononutrition

Role of Hormones and Neuropeptides in IBS and other Gastrointestinal Disorders: Understanding Variability and Chrononutrition

Potential Chonobiological Triggering Factors of Acute Heart Attack

The impact of heart rate circadian rhythm on in-hospital mortality in patients with stroke and critically ill: Insights from the eICU Collaborative Research Database

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