Can orbital artery resistive indexes detect complications of diabetes in the prediabetic phase?

Sirkeci, Ozgur; Sirkeci, Emel Erkuş; Süzer, Neslihan Ergün; Tatlıparmak, Ali Cankut; Küçükçiloğlu, Yasemin; Ulaş, Turgay

doi:10.1007/s00508-023-02212-5

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…In patients with diabetic retinopathy, PSV and EDV in the CRA, OA, and SPCAs were significantly decreased compared to controls, while the RI in these eyes was significantly higher [80]. In prediabetic patients increased RI of retrobulbar vessels was detected compared to healthy controls, thereby representing the first step in the development of microangiopathy in diabetic patients [11]. Other studies have also reported reduced retrobulbar blood flow in patients with diabetes, suggesting that changes in retrobulbar hemodynamics may play a central role in the pathogenesis of diabetic retinopathy.…”

Section: Clinical and Scientific Relevance Of CDI For Ocular And Card...mentioning

confidence: 84%

“…In this patient group, markedly reduced peak systolic blood flow velocity (PSV), end-diastolic blood flow velocity (EDV), and higher resistance index (RI) of the ophthalmic artery, central retinal artery and posterior ciliary arteries, were observed compared to patients with normal vision or low and moderate myopia [10]. Moreover, it has been proposed that an increased RI of the ophthalmic artery, central retinal artery, and posterior cerebral artery may be the first sign of developing diabetic retinopathy [11]. Given the reported link between altered retrobulbar hemodynamics and retinal and optic nerve diseases, but also between cardiovascular diseases, we aimed to present the various measurement techniques…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Böhm,

Grauhan,

Pfeiffer

et al. 2023

Diagnostics

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Abnormal retrobulbar hemodynamics have been linked to the development of various ocular diseases, including glaucoma, age-related macular degeneration, and diabetic retinopathy. Additionally, altered retrobulbar blood flow has been observed in patients with severe cardiovascular diseases, including carotid artery occlusion, stroke, heart failure, and acute coronary syndrome. Due to the complex and intricate anatomy of retrobulbar blood vessels and their location behind the eyeball, measurement of retrobulbar blood flow and vascular reactivity, as well as the interpretation of the findings, are challenging. Various methods, such as color Doppler imaging, computed tomography angiography or magnetic resonance imaging, have been employed to assess retrobulbar blood flow velocities in vivo. Color Doppler imaging represents a fast and non-invasive method to measure retrobulbar blood flow velocities in vivo. While no information about vessel diameter can be gained performing this method, computed tomography angiography and magnetic resonance imaging provide information about vessel diameter and detailed information on the anatomical course. Additionally, ex vivo studies, such as myography, utilizing genetically modified animal models may provide high optical resolution for functional vascular investigations in these small vessels. To our best knowledge, this is the first review, presenting a detailed overview of methods aiming to evaluate retrobulbar blood flow and vascular reactivity in both humans and laboratory animals. Furthermore, we will summarize the disturbances observed in retrobulbar blood flow in retinal, optic nerve, and cardiovascular diseases.

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Section: Clinical and Scientific Relevance Of CDI For Ocular And Card...mentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Böhm,

Grauhan,

Pfeiffer

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

Can orbital artery resistive indexes detect complications of diabetes in the prediabetic phase?

Cited by 1 publication

References 18 publications

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

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